Results 151 to 160 of about 1,245 (201)

Ciguatoxins activate the Calcineurin signalling pathway in Yeasts: Potential for development of an alternative detection tool?

Environmental Research, 2018
Ciguatoxins (CTXs) are lipid-soluble polyether compounds produced by dinoflagellates from the genus Gambierdiscus spp. typically found in tropical and subtropical zones.
Hélène Martin-Yken, Camille Gironde, Hélène Taiana Darius   +2 more
exaly   +2 more sources

Release of neuropeptides from a neuro-cutaneous co-culture model: A novel in vitro model for studying sensory effects of ciguatoxins

Toxicon, 2016
Ciguatoxins are the major toxins responsible for ciguatera fish poisoning, a disease dominated by muco-cutaneous sensory disorders including paresthesiae, cold dysesthesia and pruritus.
Raphaele Le Garrec, Killian L'Herondelle, Christelle Le Gall-Ianotto   +2 more
exaly   +2 more sources

Biooxidation of Ciguatoxins Leads to Species-Specific Toxin Profiles

Toxins, 2017
Ciguatoxins (CTXs) contaminate fish worldwide and cause the foodborne illness ciguatera. In the Pacific, these toxins are produced by the dinoflagellate Gambierdiscus toxicus, which accumulates in fish through the food chain and undergoes oxidative ...
Tsuyoshi Ikehara, Kyoko Kuniyoshi, Naomasa Oshiro   +2 more
exaly   +2 more sources

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Ciguatoxin-2 is a diastereomer of ciguatoxin-3

Toxicon, 1993
Ciguatoxin-2, a major ciguatoxin present in the flesh and viscera of ciguateric fishes, has been shown by 1H nuclear magnetic resonance studies (2-dimensional homonuclear Hartman Hahn, nuclear Overhauser effect and decoupling difference experiments) to be a diastereomer of ciguatoxin-3, differing only in stereochemistry at carbon 52 (a quaternary ...
Lewis, RJ, Norton, RS, Brereton, IM, Eccles, CD   +3 more
openaire   +5 more sources

A radioimmunoassay for the detection of ciguatoxin

Toxicon, 1977
Abstract A practical, sensitive, simple and relatively specific radioimmunoassay test for the assay of ciguatoxin directly from natural sources has been developed. The radioimmunoassay test has been utilized to distinguish the toxic fishes in human ciguatera poisoning outbreaks from the nontoxic fishes.
Y, Hokama, A H, Banner, D B, Boylan
openaire   +2 more sources

Total Synthesis of Ciguatoxin

Angewandte Chemie, 2009
AbstractEines der Haupttoxine bei Fischvergiftungen, das Ciguatoxin (siehe Struktur), war Ziel einer Totalsynthese. Der Syntheseweg beruht auf der Kupplung dreier Segmente, und die Schlüsselumwandlungen umfassen eine Komplexbildung zwischen Acetylen und Dicobalthexacarbonyl.magnified ...
Akinari, Hamajima, Minoru, Isobe
openaire   +2 more sources

Detection of pacific ciguatoxins using liquid chromatography coupled to either low or high resolution mass spectrometry (LC-MS/MS)

Journal of Chromatography A, 2018
International audienceCiguatera Fish Poisoning (CFP) is primarily caused by consumption of tropical and sub-tropical fish contaminated by Ciguatoxins (CTXs).
Manoella Sibat, Christine Herrenknecht, Hélène Taiana Darius   +2 more
exaly   +3 more sources

Ciguatoxin and Ciguatera

2015
Ciguatera is a disease caused by the consumption of fishes from tropical and subtropical waters that have accumulated lipophilic sodium channel activator toxins known as ciguatoxins (CTXs) to levels sufficient to cause human poisoning. Consumption of these temperature-stable, orally active polycyclic ether compounds leads to the activation of neuronal ...
Lewis, Richard J., Vetter, Irina
openaire   +3 more sources

Toxicology of Ciguatoxins

2014
Ciguatera is a common form of fish intoxication that is caused by ingestion of tropical fishes that have bioaccumulated the lipophilic cyclic polyether toxins know as ciguatoxins (CTXs). Consumption of these temperaturestable, orally effective sodium channel activators causes the characteristic neurological, gastrointestinal and cardiovascular symptoms
Vetter, I., Lewis, R. J.
openaire   +3 more sources

Ciguatoxin: More Than an Anticholinesterase

Science, 1968
Anticholinesterase action of ciguatoxin has been reported. A study of the pharmacology of the action of the toxin on the respiratory system suggests that additional properties may be involved in the respiratory failure—the usual cause of death in ciguatera poisoning.
M D, Rayner, T I, Kosaki, E L, Fellmeth
openaire   +2 more sources