Results 131 to 140 of about 724 (169)
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2000
Abstract Ciguatoxin is a partially characterized, heat-stable, lipid soluble compound elaborated by the photosynthetic dino flagellate Gambierdiscus toxicus (40). The toxin is stored in the viscera of fish and passed along the food chain to progressively larger carnivorous fish. Ingestion of these fish leads to neurological, autonomic,
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Abstract Ciguatoxin is a partially characterized, heat-stable, lipid soluble compound elaborated by the photosynthetic dino flagellate Gambierdiscus toxicus (40). The toxin is stored in the viscera of fish and passed along the food chain to progressively larger carnivorous fish. Ingestion of these fish leads to neurological, autonomic,
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Action of ciguatoxin on human atrial trabeculae
Toxicon, 1992This report describes the action of ciguatoxin-1, the major ciguatoxin present in fishes that cause ciguatera, on the contractile activity of human cardiac musculature. Ciguatoxin-1 caused a large, sustained and concentration-dependent positive inotropy in human atrial trabeculae that were obtained during coronary artery bypass surgery from otherwise ...
Lewis, RJ, Hoy, Aww, McGiffin, DC
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Recovery of ciguatoxin from fish flesh
Toxicon, 1993A mouse bioassay, validated for the quantification of ciguatoxin in up to 20 mg of ether extract from fish flesh, revealed that 63 +/- 14% of spiked ciguatoxin was recovered using a standard extraction procedure. Except for extracts from the least toxic of ciguateric fish (0.1-0.5 nmol ciguatoxin-1/kg fish), signs in mice of intoxication by ciguatoxin (
Lewis, RJ, Sellin, M
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The transport of ciguatoxin: A case report
The Journal of Emergency Medicine, 2001Ciguatera fish poisoning has been responsible for as many as half of all food poisonings in the United States due to fish. Because the initial symptoms often include gastrointestinal symptoms, such as nausea, vomiting, diarrhea, and abdominal pain, patients may be discharged from the Emergency Department with a diagnosis of "acute gastroenteritis ...
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Ciguatoxin reduces larval survivability in finfish
Toxicon, 1999Ciguatoxins are lipophilic polyether toxins which concentrate in the viscera and flesh of coral reef associated finfish (Hessel et al., 1960). In this study, we quantify the adverse effects of ciguatoxin on fish embryos by microinjection into the egg yolk of medaka (Oryzias latipis) embryos. Embryos microinjected with 0.1-0.9 pg/egg (ppb) of ciguatoxin
J S, Edmunds +2 more
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Analytical challenges to ciguatoxins
Current Opinion in Food Science, 2017Ciguatera fish poisoning (CFP) is a form of food poisoning caused by consumption of varieties of toxic ciguatera fish species from tropical and subtropical waters. In the present review, significant features and perspective of LC/MS methods for CTXs as confirmatory methods are reviewed on the discussion for one of the best LC/MS/MS method reported by ...
Toshiyuki Suzuki +3 more
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Natural Toxins, 1992
AbstractAfter repeated ip and oral administrations of ciguatoxin (CTX) and ciguatoxin‐4c (CTX‐4c), one of the derivatives of CTX, to male ICR mice at a dose of 0.1 μg/kg for 15 days, resulted in marked swelling of cardiac cells and endothelial lining cells of blood capillaries in the heart was observed.
K, Terao, E, Ito, T, Yasumoto
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AbstractAfter repeated ip and oral administrations of ciguatoxin (CTX) and ciguatoxin‐4c (CTX‐4c), one of the derivatives of CTX, to male ICR mice at a dose of 0.1 μg/kg for 15 days, resulted in marked swelling of cardiac cells and endothelial lining cells of blood capillaries in the heart was observed.
K, Terao, E, Ito, T, Yasumoto
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A Concise Route to the Right Wing of Ciguatoxin.
ChemInform, 2003AbstractFor Abstract see ChemInform Abstract in Full Text.
Atsushi Tatami +3 more
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Total Synthesis of Ciguatoxin and 51-HydroxyCTX3C
Journal of the American Chemical Society, 2006Ciguatoxins, the principal causative toxins of ciguatera seafood poisoning, are large ladder-like polycyclic ethers with the 13 ether rings ranging from five- to nine-membered. In this paper, we describe the total synthesis of the two most toxic members of the ciguatoxin family, ciguatoxin 1 and 51-hydroxyCTX3C 2, based on a unified synthetic strategy.
Masayuki, Inoue +9 more
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Ciguatoxin: developing the methodology for total synthesis
Natural Product Reports, 2010Covering: up to 2009 The ciguatoxins are sodium channel toxins from the marine dinoflagellate Gambierdiscus toxicus, isolated in 1984. In this review, we summarize the principal concepts and recently developed methodologies for the synthesis of the ciguatoxins, including C–C bond formation by silylacetylene and cobalt-mediated cyclization.
Minoru, Isobe, Akinari, Hamajima
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