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Multiple ciguatoxins in the flesh of fish
Toxicon, 1992Most cases of ciguatera (fish poisoning) result from consumption of the flesh of fishes contaminated with ciguatoxin(s); however, the relatively low toxicity of ciguateric fish flesh has hindered attempts to identify these ciguatoxin(s). Utilising high performance liquid chromatography, mass spectroscopy and mouse bioassay signs we have determined that
Lewis, Richard J., Sellin, Michelle
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Ciguatoxins are potent ichthyotoxins
Toxicon, 1992The ciguatoxins are lipid soluble polyether compounds which have structural and biochemical features in common with the brevetoxins. Pure ciguatoxin-1, ciguatoxin-2 or brevetoxin-2 added to water containing Gambusia affinis induced similar signs, including pronounced opercular movement and uncoordinated swimming preceding death. The estimated LD50s (48
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Ciguatoxin: More Than an Anticholinesterase
Science, 1968Anticholinesterase action of ciguatoxin has been reported. A study of the pharmacology of the action of the toxin on the respiratory system suggests that additional properties may be involved in the respiratory failure—the usual cause of death in ciguatera poisoning.
M D, Rayner, T I, Kosaki, E L, Fellmeth
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An investigation into ciguatoxin bioaccumulation in sharks
Toxicon, 2016Ciguatoxins (CTXs) produced by benthic Gambierdiscus dinoflagellates, readily biotransform and bioaccumulate in food chains ultimately bioconcentrating in high-order, carnivorous marine species. Certain shark species, often feeding at, or near the top of the food-chain have the ability to bioaccumulate a suite of toxins, from both anthropogenic and ...
Lauren Meyer +3 more
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Ciguatoxin: Isolation and Chemical Nature
Science, 1967Ciguatoxin, the agent responsible for ciguatera, a disease produced in humans from ingestion of certain fishes, has been isolated from specimens of the moray eel, Gymnothorax javanicus . The toxin is apparently a lipid containing quaternary nitrogen, hydroxyl, and carbonyl functions.
P J, Scheuer +3 more
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Two interchangeable forms of ciguatoxin
Toxicon, 1984Ciguatoxin, the principal toxin responsible for ciguatera, isolated from moray eel viscera, has been separated into two distinct components by alumina chromatography. A series of chromatographies showed that the two components are interchangeable. This proves that ciguatoxin is a single molecular entity.
M, Nukina, L M, Koyanagi, P J, Scheuer
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Total Synthesis of Ciguatoxin CTX3C
Science, 2001More than 20,000 people suffer annually from ciguatera seafood poisoning in subtropical and tropical regions. The extremely low content of the causative neurotoxins, designated as ciguatoxins, in fish has hampered the isolation, detailed biological studies, and preparation of anti-ciguatoxin antibodies for detecting these toxins.
M, Hirama +6 more
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Polyneuropathy secondary to ciguatoxin poisoning
The Italian Journal of Neurological Sciences, 1988Following ingestion of marine fish in Thailand this patient complained of gastrointestinal and neurological disturbances, marked by severe, mainly motor, demyelinating polyneuropathy, which worsened on her return to Italy a few days later. The clinical pattern, electromyography, cerebrospinal fluid test and sural nerve biopsy by electronmicroscopy ...
Sozzi, G +4 more
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Optimization of ciguatoxin extraction method from blood for Pacific ciguatoxin (P-CTX-1)
Toxicon, 2007Ciguatera diagnosis relies on clinical observations associated with a recent consumption of fish. Although needed, direct confirmation of exposure in subjects showing ciguatera disease symptoms is currently unavailable. We previously reported that ciguatoxins were measurable in the blood of mice exposed to extracts of Pacific ciguatoxins isolated from ...
Marie-Yasmine, Bottein Dechraoui +2 more
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