Results 111 to 120 of about 4,425,847 (185)

Clinical Studies Applying Cytokine-Induced Killer Cells for the Treatment of Renal Cell Carcinoma

Clinical and Developmental Immunology, 2012
Metastatic renal cell carcinoma (RCC) seems to be resistant to conventional chemo- and radiotherapy and the general treatment regimen of cytokine therapy produces only modest responses while inducing severe side effects.
Clara E. Jäkel, Stefan Hauser, Sebastian Rogenhofer, Stefan C. Müller, P. Brossart, Ingo G. H. Schmidt-Wolf   +5 more
doaj   +1 more source

Macrophage-derived pro-inflammatory cytokines augment the cytotoxicity of cytokine-induced killer cells by strengthening the NKG2D pathway in multiple myeloma

Scientific Reports
Multiple myeloma (MM) is a clonal hematologic malignancy characterized by low rate of complete remissions. Cytokine-induced killer (CIK) cell therapy has shown promising benefits in MM treatment.
Peng Chen, Yinhao Chen, Yulu Wang, Amit Sharma, Lukacs-Kornek Veronika, Hans Weiher, A. Gonzalez-Carmona Maria, Ingo G. H. Schmidt-Wolf   +7 more
doaj   +1 more source

Enhanced Inhibitory Effect of DC-CIK Cells on Lung Adenocarcinoma via Anti-Tim-3 Antibody and Antiprogrammed Cell Death-1 Antibody and Possible Mechanism. [PDF]

Evid Based Complement Alternat Med, 2022
Zhou L, Chen Q, Chen H, Wang L, Zhang J.
europepmc   +1 more source

Cytokine-induced killer cells interact with tumor lysate？pulsed dendritic cells via CCR5 signaling

, 2016
The antitumor activity of cytokine-induced killer (CIK) cells can be increased by co-culturing them with tumor lysate？pulsed dendritic cells (tDCs); this phenomenon has been studied mainly at the population level.
B Kim, Y G Kim, K H Park, H K Lee, J S Kim, Jong Soon Kang, J T Hong, S B Han, E J Park, Y Kim   +9 more
core   +1 more source

Cytokine-induced killer cells are type II natural killer T cells

GMS German Medical Science, 2007
Background: Until now, cytokine-induced killer (CIK) cells were assumed to be part of the type I natural killer T (NKT) cell population, but it was not yet investigated if this is correct.
Schmidt-Wolf, Ingo G.H., Strehl, John, Frank, Susanne, Gütgemann, Stefan   +3 more
doaj  

Rh-endostatin decreases tumor hypoxic area and hypoxia inhibits the activity of CIK cells in vitro.

, 2013
A549-bearing mice were divided into two groups and were given rh-endostatin or normal saline respectively for 7 days. On days 3, 6 and 9, mice (n = 4) in the two groups were administrated with pimonidazole.
Longbang Chen (422266), Yitian Chen (422264), Rui Wang (52434), Haizhu Song (422265), Shujing Shi (422263), Guichun Huang (422267)   +5 more
core   +1 more source

Dual-functional capability of CD3+CD56+ CIK cells, a T-cell subset that acquires NK function and retains TCR-mediated specific cytotoxicity

, 2011
CD3+CD56+ cytokine-induced killer (CIK) cells display a potent cytolytic activity. The adhesion molecule lymphocyte function-associated antigen-1 plays a crucial role in binding as well as in cytolytic activity of CIK cells against tumor target cells ...
Daniela Pende, Martino Introna, Josée Golay, Alice Pievani, Alessandro Rambaldi, Lorenzo Moretta, Gianmaria Borleri   +6 more
core   +1 more source

Autologous cytokine-induced killer (CIK) cells enhance the clinical response to PD-1 blocking antibodies in patients with advanced non-small cell lung cancer: A preliminary study. [PDF]

Thorac Cancer, 2021
Han Y, Mu D, Liu T, Zhang H, Zhang J, Li S, Wang R, Du W, Hui Z, Zhang X, Ren X.   +10 more
europepmc   +1 more source

Cytotoxicity of cytokine-induced killer cells targeted by the bispecific antibody anti-CD3xanti-AFP on AFP positive hepatoma cells [PDF]

, 2010
细胞因子诱导的杀伤细胞（Cytokine-inducedKillerCell，CIK）是人外周血单个核细胞(PBMCs)经细胞因子诱导成的具有肿瘤杀伤能力的一群异质细胞。目前，CIK细胞被认为是肿瘤过继免疫细胞治疗的首选细胞，但CIK细胞对肿瘤细胞并不是特异性杀伤，其抗肿瘤效果还有待进一步提高。双特异抗体通过“抗原－抗体”的形式特异性地联结CIK细胞和靶细胞，增强了CIK细胞杀伤肿瘤细胞的靶向性和特异性，大大提高了CIK细胞对肿瘤细胞的杀伤活性。本文的目的在于建立双特异抗体anti-CD3xanti ...
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