Results 71 to 80 of about 3,206 (156)

Expanded Allelic Diversity of Non‐Classical HLA Class I and MIC Loci Identified Using Full‐Gene Hybrid Capture‐Based Next‐Generation Sequencing

HLA, Volume 108, Issue 1, July 2026.
ABSTRACT Non‐classical HLA Class I genes (HLA‐E, ‐F, ‐G, ‐H) and MHC‐related genes (MICA, MICB) regulate NK cell function and immune tolerance, yet their allelic diversity remains underexplored. Using capture‐enriched full‐gene sequencing of 943 healthy US transplant donors, we identified 26 novel alleles across HLA‐E (2), HLA‐F (6), HLA‐G (4), HLA‐H ...
Itta Krishna Chaaithanya, Pawan Kumar Raghav, Nancy Lee, Carla Wirtz, Denice Kong, Raja Rajalingam   +5 more
wiley   +1 more source

Selenium‐Based Nanoplatforms: An Emerging Theranostic Paradigm for Gynecological Cancers

Advanced Science, Volume 13, Issue 33, 15 June 2026.
This reivew summarizes Selenium as a multifunctional anticancer regulator in gynecological cancers. It reduces tumor risk, enhances therapeutic efficacy, and reduces treatment toxicity. Selenium also overcomes chemoraditherapy resistance, improving overall treatment outcomes. ABSTRACT Gynecological cancers present significant therapeutic challenges due
Hejing Liu, Yujia Zhou, Zihan Zhang, Rong Ma, Luyi Ruan, Liqing Miao, Boxin Zhang, Huihui Ji, Tianfeng Chen, Xueqiong Zhu   +9 more
wiley   +1 more source

Cytotoxic capacity of IL-15-stimulated cytokine-induced killer cells against human acute myeloid leukemia and rhabdomyosarcoma in humanized preclinical mouse models

Frontiers in Oncology, 2012
Allogeneic stem cell transplantation (allo-SCT) has become an important treatment modality for patients with high risk acute myeloid leukemia (AML) and is also under investigation for soft tissue sarcomas.
Eva eRettinger, Vida eMeyer, Hermann eKreyenberg, Andreas eVolk, Selim eKuci, Andre eWillasch, Ewa eKoscielniak, Simone eFulda, Winfried eWels, Halvard eBoenig, Thomas eKlingebiel, Peter eBader   +11 more
doaj   +1 more source

Co-culture of dendritic cells and cytokine-induced killer cells effectively suppresses liver cancer stem cell growth by inhibiting pathways in the immune system

BMC Cancer, 2018
Background Application of dendritic cells (DC) for cancer immunotherapy involves tumor-associated immunogenic antigens for effective therapeutic strategies.
Tao Yang, Wenjun Zhang, Li Wang, Chunyan Xiao, Li Wang, Yi Gong, Dehong Huang, Bingling Guo, Qiying Li, Ying Xiang, Yingyu Nan   +10 more
doaj   +1 more source

Combined Treatment with Autologous CIK Cells, Radiotherapy and Chemotherapy in Advanced Cervical Cancer

Pathology & Oncology Research, 2018
To investigate the clinical efficacy of autologous cytokine induced killer (CIK) cells transfusion combined with radiochemotherapy in the treatment of advanced cervical cancer. A total of 89 hospitalized patients with advanced cervical cancer were admitted and divided into the treatment group (44 cases, autologous CIK cells transfusion combined with ...
Ning, Li, Yong-Wei, Tian, Yue, Xu, Dan-Dan, Meng, Ling, Gao, Wen-Jie, Shen, Zong-Lan, Liu, Zhi-Qiao, Xu   +7 more
openaire   +2 more sources

Anti-tumor activities of CIK cells derived from lymph nodes of lung cancer patients

Zhongguo aizheng zazhi, 2015
Background and purpose: Cytokine-induced killer (CIK) has both the advantages of T lymphocytes’ powerful anti-tumor activity and NK cells’ tumor killing capacity without MHC restriction.
滕家俊, 周　严, 刘显勋
doaj  

Clinical Studies Applying Cytokine-Induced Killer Cells for the Treatment of Gastrointestinal Tumors

Journal of Immunology Research, 2014
Tumors of the gastrointestinal system represent a significant share of solid tumors worldwide. Despite the advances in diagnosis and treatment, the prognosis of gastrointestinal tumors is still very poor and improved therapies are indispensable. Cytokine-
Clara E. Jäkel, Annabelle Vogt, Maria A. Gonzalez-Carmona, Ingo G. H. Schmidt-Wolf   +3 more
doaj   +1 more source

Effect of chaetocin on renal cell carcinoma cells and cytokine-induced killer cells

GMS German Medical Science, 2016
We examined the cytotoxic effects of chaetocin on clear cell renal cell carcinoma (ccRCC) cells and the possibility to combine the effects of chaetocin with the effects of cytokine-induced killer cells (CIK) assayed by MTT assay and FACS analysis ...
Rombo, Roman, Weiher, Hans, Schmidt-Wolf, Ingo G.H.   +2 more
doaj   +1 more source

Autologous CIK cells combined with chemotherapy as the first-line treatment for locally advanced or metastatic gastric cancer is safe and feasible. [PDF]

Front Immunol, 2023
Ma X, Peng L, Wang J, Gao L, Zhang W, Lu X, Liu J, Yang L.   +7 more
europepmc   +1 more source

Synergistic integration of histone deacetylase inhibitors apparently enhances the cytokine‐induced killer cell efficiency in multiple myeloma via the NKG2D pathway

Clinical & Translational Immunology
Objectives The rapid recognition of epigenetic manipulation's potential in restricting cancer cell capabilities spurred translational initiatives, including histone deacetylase inhibitors (HDACis).
Jingjing Pu, Amit Sharma, Ting Liu, Jian Hou, Ingo GH Schmidt‐Wolf   +4 more
doaj   +1 more source