Results 101 to 110 of about 128,344 (306)
Crosstalk between G-protein and Ca2+ pathways switches intracellular cAMP levels [PDF]
, 2001 Cyclic adenosine monophosphate and cyclic guanosine monophosphate are universal intracellular messengers whose concentrations are regulated by molecular networks comprised of different isoforms of the synthases adenylate cyclase or guanylate cyclase and ...
A Dietz +22 more
core +1 more source
Cell, 2015 Motile cilia are hair-like organelles that protrude from the cell surface and are conserved throughout eukaryotes. Motile cilia beat rhythmically and function in cellular and organismal locomotion and in driving fluid transport over epithelia. In vertebrates, their roles are varied, and their dysfunction in humans is associated with disease.
Zhou, Feng, Roy, Sudipto
openaire +2 more sources
Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss
Advanced Science, EarlyView.. ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao +9 more
wiley +1 more source
Absolute proteomic quantification reveals design principles of sperm flagellar chemosensation [PDF]
, 2019 © The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Troetschel, C., Hamzeh, H., Alvarez, L., Pascal, R., Lavryk, F., Boenigk, W., Koerschen, H.
Alvarez, Luis +14 more
core +1 more source
Advanced Science, EarlyView.A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui +9 more
wiley +1 more source
Proteomic analysis of multiple primary cilia reveals a novel mode of ciliary development in mammals
Biology Open, 2012 Summary Cilia are structurally and functionally diverse organelles, whose malfunction leads to ciliopathies. While recent studies have uncovered common ciliary transport mechanisms, limited information is available on the proteome of cilia, particularly ...
Keishi Narita +9 more
doaj +1 more source
Kinesin‐Induced Buckling Reveals the Limits of Microtubule Self‐Repair
Advanced Science, EarlyView.This study shows that kinesin‐driven buckling induces extensive microtubule lattice damage that often exceeds intrinsic self‐repair and leads to filament failure. While curvature, motor motility, and force individually cause limited damage, their combination overwhelms repair.
Shweta Nandakumar +9 more
wiley +1 more source
Collective beating of artificial microcilia
, 2011 We combine technical, experimental and theoretical efforts to investigate the collective dynamics of artificial microcilia in a viscous fluid. We take advantage of soft-lithography and colloidal self-assembly to devise microcapets made of hundreds of ...
Antoine Bricard +8 more
core +1 more source
Advanced Science, EarlyView.Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong +24 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv +8 more
wiley +1 more source