Results 161 to 170 of about 53,416 (270)

Genetic Risk Factors in Normal Pressure Hydrocephalus: What We Know and What Is Next

open access: yesMovement Disorders, EarlyView.
Abstract Knowledge of the genetic factors in normal pressure hydrocephalus (NPH) is rapidly evolving, with significant advances in recent years. We conducted a systematic review examining genetic contributions to NPH risk. Ovid Embase, Ovid Medline, Web of Science, and Cochrane Central were searched from inception through October 14, 2024, for human ...
Camila C. Piccinin   +9 more
wiley   +1 more source

Low‐concentration atropine eyedrops for myopia control in a multi‐racial cohort of Australian children: A randomised clinical trial

open access: yesClinical &Experimental Ophthalmology, Volume 50, Issue 9, Page 1001-1012, December 2022., 2022
Abstract Background To test the hypothesis that 0.01% atropine eyedrops are a safe and effective myopia‐control approach in Australian children. Methods Children (6–16 years; 49% Europeans, 18% East Asian, 22% South Asian, and 12% other/mixed ancestry) with documented myopia progression were enrolled into this single‐centre randomised, parallel, double‐
Samantha Sze‐Yee Lee   +13 more
wiley   +1 more source

Drug and siRNA screens identify ROCK2 as a therapeutic target for ciliopathies. [PDF]

open access: yesCommun Med (Lond)
Smith CEL   +16 more
europepmc   +1 more source

Evaluating Adverse Outcomes After Myringotomy or Tube Placement in Head and Neck Cancer

open access: yesOtolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Evaluate rates of adverse outcomes among patients with a history of head and neck cancer undergoing myringotomy with or without tube placement for middle ear effusion. Study Design Retrospective chart review. Setting Academic medical center.
Krithika Kuppusamy   +7 more
wiley   +1 more source

Evaluation of Benzo[cd]indol‐2(1H)‐ones as Downstream Hedgehog Pathway Inhibitors

open access: yesChemistryOpen, EarlyView.
Benzo[cd]indol‐2(1H)‐one 1 inhibits the Hedgehog signaling pathway downstream of Suppressor of Fused, lowering cellular and ciliary GLI2 levels, and preventing GLI1 expression. A PROTAC‐based competition assay validated the cellular engagement of BET bromodomains, adding compound 1 to the growing set of epigenetic modulators of the Hedgehog signaling ...
Ioannis A. Tsakoumagkos   +8 more
wiley   +1 more source

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