The evolution of reproduction in Ediacaran–Cambrian metazoans
ABSTRACT The evolution of reproductive style is a fundamental aspect of metazoan life history but has not been explored holistically through the Ediacaran–Cambrian rise of metazoans. Recent molecular clock analyses based on only unequivocal metazoan fossil calibrations suggest that Porifera were present by at least 590 million years ago (Ma), all major
Rachel A. Wood, Mary L. Droser
wiley +1 more source
Mutations in NEK1 cause ciliary dysfunction as a novel pathogenic mechanism in amyotrophic lateral sclerosis. [PDF]
Noh MY+10 more
europepmc +1 more source
Re‐make, re‐model: evolution and development of vertebrate cranial lateral lines
ABSTRACT Lateral lines are placodally derived mechanosensory systems on the heads and trunks of many aquatic vertebrates. There is evidence of lateral lines in the earliest known vertebrate fossils, and they exist in organisms with widely different craniofacial morphologies – including the presence or absence of jaws, external or internal nostrils, and
Vishruth Venkataraman+3 more
wiley +1 more source
Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications. [PDF]
Wang Z+5 more
europepmc +1 more source
FGFR2 residence in primary cilia is necessary for epithelial cell signaling. [PDF]
Nita A+19 more
europepmc +1 more source
Seasonal Variation in HLA‐B27 Associated Uveitis
ABSTRACT Background To examine if there was a monthly variation in HLA‐B27‐associated uveitis. Methods Retrospective review of all individuals presenting to a single centre with HLA‐B27‐associated uveitis from 2009 to 2020. Results 577 participants with HLA‐B27‐associated uveitis were included. The median age at presentation was 40.4 years (IQR 31.1–51.
Priya D. Samalia+3 more
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CEP162: A critical regulator of ciliary transition zone assembly and its implications in ciliopathies. [PDF]
Yin J+7 more
europepmc +1 more source
Cataract Surgery in the Small Adult Eye: A Review
ABSTRACT Modern cataract surgery continues to advance, yet intraocular lens (IOL) based surgery in the small adult eye remains challenging. Thorough preoperative assessment and surgical preparation optimise postoperative outcomes in these cases. Advances in IOL power calculation, including artificial intelligence‐driven formulas, improve accuracy ...
Jonathan E. Moore+2 more
wiley +1 more source
Silicon Carbide Nanowires Impair Mucociliary Clearance-Mediated Innate Immunity in Primary Human Bronchial Epithelial Cells. [PDF]
Wang Z+9 more
europepmc +1 more source