Results 61 to 70 of about 53,999 (295)
Advanced Materials Technologies, EarlyView.Renal tubular injury is a major contributor to kidney disease, yet remains poorly understood due to the lack of predictive models. This study presents a high‐throughput 3D renal proximal tubule model on the AngioPlate platform integrated with automated TEER measurements (AngioTEER), enabling real‐time monitoring of drug‐induced nephrotoxicity ...
Shravanthi Rajasekar +13 more
wiley +1 more source
Cell Reports, 2013 The role for cilia in establishing planar cell polarity (PCP) is contentious. Although knockdown of genes known to function in ciliogenesis has been reported to cause PCP-related morphogenesis defects in zebrafish, genetic mutations affecting ...
Antonia Borovina, Brian Ciruna
doaj +1 more source
IFT46 Expression in the Nasal Mucosa of Primary Ciliary Dyskinesia Patients: Preliminary Study
Allergy & Rhinology, 2021 Background Primary ciliary dyskinesia (PCD) is characterised by an imbalance in mucociliary clearance leading to chronic respiratory infections. Cilia length is considered to be a contributing factor in cilia movement.
Manuel Mata PhD +6 more
doaj +1 more source
Cilia develop long-lasting contacts, with other cilia [PDF]
Cilia, 2012 The primary cilium has been much celebrated for its central role as a sensory organelle. Whether we consider odorants binding to odorant receptors in olfactory cilia or light stimulating rhodopsin in the retinal outer segment, core ciliary structures and G-protein coupled receptors like rhodopsin allow our senses to function.
openaire +3 more sources
NOX2 Contributes to High‐Frequency Outer Hair Cell Vulnerability in the Cochlea
Advanced Science, EarlyView.This study first identifies NOX2 as a differentially expressed gene related to oxidative damage in the apical and basal turns through single‐cell RNA sequencing. NOX2 gene knockout mitigates OHCs damage caused by neomycin and noise and enhances Nrf2 expression and nuclear translocation.
Meihao Qi +16 more
wiley +1 more source
Cilia and Mucociliary Clearance [PDF]
Cold Spring Harbor Perspectives in Biology, 2016 Mucociliary clearance (MCC) is the primary innate defense mechanism of the lung. The functional components are the protective mucous layer, the airway surface liquid layer, and the cilia on the surface of ciliated cells. The cilia are specialized organelles that beat in metachronal waves to propel pathogens and inhaled particles trapped in the mucous ...
Ximena M. Bustamante-Marin +1 more
openaire +3 more sources
Advanced Science, EarlyView.Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei +15 more
wiley +1 more source
Dermatology and TherapyIntroduction Skin aging, which results from intrinsic and extrinsic factors, is characterized by a rough, uneven and wrinkled appearance of the skin at the macroscopic level.
Hanane Chajra +6 more
doaj +1 more source
A protocol for generation and live-cell imaging analysis of primary cilia reporter cell lines
STAR Protocols, 2022 Summary: Primary cilia are hair-like sensory organelles protruding from the surface of most human cells. As cilia are dynamic, several aspects of their biology can only be revealed by real-time analysis in living cells. Here we describe the generation of
Lucia Binó +9 more
doaj
The Morphological, Behavioral, and Transcriptomic Life Cycle of Anthrobots
Advanced Science, EarlyView.DNA is thought to determine shape, behavior, and lifespan, with developmental plasticity reserved for stem cells, embryos, and species like amphibia. How much morphogenetic plasticity do adult somatic human cells exhibit? Anthrobots are a self‐organizing, motile synthetic living construct made of genetically normal human epithelial cells.
Gizem Gumuskaya +6 more
wiley +1 more source