Results 61 to 70 of about 164,456 (390)
Neuronal cilia in energy homeostasis
Frontiers in Cell and Developmental Biology, 2022 A subset of genetic disorders termed ciliopathies are associated with obesity. The mechanisms behind cilia dysfunction and altered energy homeostasis in these syndromes are complex and likely involve deficits in both development and adult homeostasis ...
Kathryn M. Brewer +5 more
doaj +1 more source
Crosstalk between G-protein and Ca2+ pathways switches intracellular cAMP levels [PDF]
, 2001 Cyclic adenosine monophosphate and cyclic guanosine monophosphate are universal intracellular messengers whose concentrations are regulated by molecular networks comprised of different isoforms of the synthases adenylate cyclase or guanylate cyclase and ...
A Dietz +22 more
core +1 more source
ciliaFA : a research tool for automated, high-throughput measurement of ciliary beat frequency using freely available software [PDF]
, 2012 Background: Analysis of ciliary function for assessment of patients suspected of primary ciliary dyskinesia (PCD) and for research studies of respiratory and ependymal cilia requires assessment of both ciliary beat pattern and beat frequency.
C O’Callaghan +19 more
core +1 more source
Frontiers in Cellular Neuroscience, 2019 In the adult mammalian brain, the apical surface of the subependymal zone (SEZ) is covered by many motile ependymal cilia and a few primary cilia originating from rare intermingled neural stem cells (NSCs).
Sara Monaco +5 more
doaj +1 more source
Cilia Action in Islets: Lessons From Mouse Models
Frontiers in Endocrinology, 2022 Primary cilia as a signaling organelle have garnered recent attention as a regulator of pancreatic islet function. These rod-like sensors exist on all major islet endocrine cell types and transduce a variety of external cues, while dysregulation of cilia
Jung Hoon Cho, Jing W. Hughes
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Efficiency optimization and symmetry-breaking in a model of ciliary locomotion
, 2010 A variety of swimming microorganisms, called ciliates, exploit the bending of a large number of small and densely-packed organelles, termed cilia, in order to propel themselves in a viscous fluid.
Lauga, Eric, Michelin, Sebastien
core +3 more sources
Effect of Cilia Orientation in Metachronal Transport of Microparticles [PDF]
, 2017 A biomimetic approach is used to generate a directed transversal transportation of micron-sized particles in liquids based on the principle of cilia-type arrays in coordinated motion.
Brücker, C. +3 more
core +2 more sources
Tau-tubulin kinase 2 restrains microtubule-depolymerizer KIF2A to support primary cilia growth
Cell Communication and SignalingBackground Primary cilia facilitate cellular signalling and play critical roles in development, homeostasis, and disease. Their assembly is under the control of Tau-Tubulin Kinase 2 (TTBK2), a key enzyme mutated in patients with spinocerebellar ataxia ...
David Benk Vysloužil +8 more
doaj +1 more source
Ubiquitin chains earmark GPCRs for BBSome-mediated removal from cilia
Journal of Cell Biology, 2020 Shinde et al. find that activation of G protein–coupled receptors (GPCRs) inside cilia triggers formation of ubiquitin chains onto the receptors via β-arrestin and that ubiquitin chains commit the GPCRs for exit from cilia.
S. R. Shinde, Andrew R Nager, M. Nachury
semanticscholar +1 more source