Results 221 to 230 of about 30,170 (290)

Epigenetic Dysregulation of the NKX2‐1/SPDEF Axis Drives Persistent Goblet Cell Differentiation and Epithelial Barrier Dysfunction in Chronic Obstructive Pulmonary Disease

Respirology, EarlyView.
This study investigated airway epithelial barrier dysfunction persistence in ex‐smokers with COPD and underlying mechanisms using single‐cell RNA and ATAC sequencing. Epigenetic NKX2‐1/SPDEF dysregulation maintains goblet cell hyperplasia and barrier dysfunction despite long‐term smoking cessation.
Ayaka Shiota, Keiko Kan‐o, Yumiko Ishii, Tomoaki Koga, Takeshi Sawada, Kei‐ichiro Yasunaga, Shingo Usuki, Tatsuya Katsuno, Shigesato Inoue, Tomohiro Ogawa, Akihiro Jo, Satoru Fukuyama, Mitsuyoshi Nakao, Hiroaki Ogata, Mizuho A. Kido, Sachiko Tsukita, Koichiro Matsumoto, Isamu Okamoto   +17 more
wiley   +1 more source

Adenine DNA methylation associated with transcriptionally permissive chromatin is widespread across eukaryotes. [PDF]

Nat Genet
Romero Charria P, Navarrete C, Ovchinnikov V, Xu L, Sarre LA, Shabardina V, Ksiezopolska E, Casacuberta E, Lara-Astiaso D, Sebé-Pedrós A, de Mendoza A.   +10 more
europepmc   +1 more source

G Protein–Coupled Receptors in Olfactory Signaling and Related Disorders: Mechanisms and Therapeutic Implications

Sensory Neuroscience, EarlyView.
This schematic highlights GPCRs as the central hub of olfactory signaling in health and disease. The central GPCR shows odorant activation and downstream pathways. Surrounding quadrants illustrate four GPCR‐mediated themes: odor perception and adaptation, mucosal immunity and regeneration, memory consolidation via neural circuits, and GPCR‐related ...
Zishuo Guo, Hongjie Du, Fanyu Yuan, Yuhan Dong, Fangyuan Zhu, Jian Liu, Chengzhilin Li, Xu Guo, Zhaoze Yang, Wenwen Qi, Ming Xia, Chengcheng Liu   +11 more
wiley   +1 more source

Identification and bioinformatics analysis of cilia-associated gene families in <i>Euplotes amieti</i> (Ciliophora, Hypotrichia). [PDF]

Front Microbiol
Shen L, Xiong X, Xu Z, Liu Y, Sheng Y, Sheng X.   +5 more
europepmc   +1 more source

Role of Hearing Loss Genes in the Sensory Epithelia Associated With Meniere Disease

Sensory Neuroscience, EarlyView.
ABSTRACT Meniere disease (MD) is an inner ear disorder characterized by episodic vertigo, tinnitus, fluctuating sensorineural hearing loss (SNHL), and aural fullness. Its hallmark pathological feature is endolymphatic hydrops. MD shows significant familial clustering in European and East Asian populations, supporting a strong genetic component in ...
Jose A. Lopez‐Escamez, Qiuyue Mao, Patricia Perez‐Carpena   +2 more
wiley   +1 more source

The Freshwater Ciliate <i>Coleps hirtus</i> as a Model Organism for Metal and Nanoparticle Toxicity: Mixture Interactions and Antioxidant Responses. [PDF]

J Xenobiot
Varatharajan GR, Coletta M, Kumar S, Bharti D, Ghosh A, Singh S, Kharkwal AC, Dondero F, La Terza A.   +8 more
europepmc   +1 more source

Exploring the Impact of Polystyrene Microplastic Beads on Male Gonads of the Marine Mussel, Mytilus galloprovincialis

Environmental Toxicology, EarlyView.
ABSTRACT Plastic, with its remarkable versatility and numerous applications, has greatly benefited humanity. However, its extreme resistance to natural degradation means it persists in the environment for long periods, causing global environmental problems.
Teresa Chianese, Mariachiara Galati, Tiziana Cappello, Maria Maisano, Gennaro Lettieri, Carmela Marinaro, Marina Piscopo, Gianluca Fasciolo, Carlos Gravato, Gaetana Napolitano, Giulia Paolella, Annamaria Locascio, Rosaria Scudiero, Luigi Rosati   +13 more
wiley   +1 more source

Genome content reorganization in the non-model ciliate Chilodonella uncinata: insights into nuclear architecture, DNA content, and chromosome fragmentation during macronuclear development. [PDF]

mSphere
Ahsan R, Maurer-Alcalá XX, Katz LA.
europepmc   +1 more source

Effects of Glyphosate on the Planktonic Microbiota: An Experimental Approach

Environmental Toxicology, EarlyView.
ABSTRACT Glyphosate is one of the most widely used herbicides in the world, including in Brazil, and its dispersion through habitats and surface waters can impact entire aquatic ecosystems. However, experimental studies evaluating the effects of pesticides on whole planktonic communities, considering attributes such as richness, density and composition—
Melissa Progênio, Matheus Henrique Oliveira de Matos, Edilaine Corrêa Leite, Bianca Ramos de Meira, João Vitor Bredariol, José Eduardo Gonçalves, Pablo Augusto Poleto Antiqueira, Luiz Felipe Machado Velho   +7 more
wiley   +1 more source

Linear covariation between germline and somatic mutation rates across ciliates and mammals. [PDF]

Curr Biol
Wang G, Fu L, Miao W, Zhang J.
europepmc   +1 more source