Results 121 to 130 of about 36,064 (332)

Minimal design of a synthetic cilium

Physical Review Research
We study a slender filament beating in a viscous fluid with novel curvature-dependent bending stiffness. Our numerical and experimental investigations reveal that such differential stiffness can sustain planar bending waves far along flexible filaments, in stark contrast to the uniform-stiffness case which requires more sophisticated control.
Clément Moreau, Benjamin J. Walker, Rebecca N. Poon, Daniel Soto, Daniel I. Goldman, Eamonn A. Gaffney, Kirsty Y. Wan   +6 more
openaire   +4 more sources

Exome Sequencing Reveals the Genetic Architecture of Non‐syndromic Orofacial Clefts and Identifies BOC as a Novel Causal Gene

Advanced Science, EarlyView.
Nonsyndromic orofacial clefts (NSOFCs) are the most common craniofacial defects. Exome sequencing of 214 sporadic cases sheds new light on its genetic architecture and identifies many candidate pathogenic variants. Furthermore, functional studies establish BOC as a novel causal gene and reveal an unusual two‐locus model of inheritance via the epistatic
Qing He, Min Yu, Yuhua Jiao, Yizhu Xu, Xuqin Liang, Wenbin Huang, Linping Xu, Yuxia Hou, Zhanping Ren, Beile Lyu, Zhenwei Qian, Pengpeng Liu, Jing Zhou, Huimei Huang, Chunyan Yin, Huaxiang Zhao, Yi Ding   +16 more
wiley   +1 more source

The C-terminus of CFAP410 forms a tetrameric helical bundle that is essential for its localization to the basal body

Open Biology
Cilia are antenna-like organelles protruding from the surface of many cell types in the human body. Defects in ciliary structure or function often lead to diseases that are collectively called ciliopathies.
Alexander Stadler, Laryssa V. De Liz, Heloisa B. Gabriel, Santiago Alonso-Gil, Robbie Crickley, Katharina Korbula, Bojan Žagrović, Sue Vaughan, Jack D. Sunter, Gang Dong   +9 more
doaj   +1 more source

Stem cell decisions:A twist of fate or a niche market? [PDF]

, 2014
Establishing and maintaining cell fate in the right place at the right time is a key requirement for normal tissue maintenance. Stem cells are at the core of this process.
Anderson, Barker, Bellis, Bettencourt-Dias, Bowman, Brawley, Buczacki, Cabernard, Cairns, Callaini, Cao, Carmena, Castanon, Castanon, Chen, Cheng, Chrétien, Clevers, Conduit, Conti, Das, Delgehyr, Doe, Du, Durand, Falconer, Gillies, Gonzalez, Goulas, Graser, Habib, Hotz, Hsu, Inke Näthke, Ishikawa, Izumi, Izumi, Januschke, Januschke, Januschke, Jauffred, Jens Januschke, Johnston, Juanes, Kai, Knoblich, Konno, Kouzarides, Lander, Lansdorp, Lechler, Lerit, Liakopoulos, Lim, Lu, Lu, Lécuyer, Mapelli, Merdes, Moore, Morin, Morin, Morrison, Neumüller, Nigg, Nipper, Ouellet, Paridaen, Pelletier, Pereira, Piel, Postiglione, Potten, Poulson, Quyn, Razafsky, Rebollo, Rebollo, Regan, Reiter, Rocheteau, Rogers, Rusan, Sato, Segalen, Segalen, Shaw, Shitamukai, Siller, Siller, Smith, Speicher, Tajbakhsh, Takeda, Tian, Tran, Vorobjev, Wall, Wang, Wang, Wang, Werts, Williams, Wu, Yadlapalli, Yadlapalli, Yamashita, Yamashita, Yamashita, Yennek, Yoshiura, Yu, Zou   +112 more
core   +2 more sources

Real‐Time Evolutionary Landscape of the Bronchial Epithelium and Corresponding Dynamic Immune Cell Alterations in Lung Squamous Cell Carcinogenesis

Advanced Science, EarlyView.
Lung squamous cell carcinoma (LUSC) is often preceded by sequential premalignant lesions with an increasing probability of malignant progression. Using single‐cell RNA sequencing, the dynamic cellular evolution from normal lung to LUSC tissues is delineated; clonal structure of premalignant and malignant epithelium is reveled; the conversion of immune ...
Baohong Luo, Yuting Luo, Sicheng Chen, Tiantian Yang, Bixia Liu, Xiting Liao, Xiaoke Zheng, Tian Tian, Jinxu Liu, Qinru Zhan, Xiaohua Situ, Zhongpeng Xie, Yanxia Wang, Zhe‐Sheng Chen, Honglei Chen, Zheng Yang, Zunfu Ke   +16 more
wiley   +1 more source

The Nuclear Localization of ACLY Guards Early Embryo Development Through Recruiting P300 and HAT1 to Promote Histone Acetylation and Transcription

Advanced Science, EarlyView.
ACLY is vital for early embryo development. IGF‐1 activates AKT to phosphorylate ACLY, driving its nuclear localization and recruitment of HATs (P300/HAT1), boosting acetyl‐CoA production and histone acetylation for transcriptional activation. Conversely, ACLY deficiency (via knockdown, knockout, or AKT inhibition) reduces nuclear acetyl‐CoA, disrupts ...
Yerong Ma, Yingyi Zhang, Weijie Yang, Xiaomei Tong, Siya Liu, Yan Zhou, Mengjia Qiu, Huifang Jiang, Zhanhong Hu, Peipei Ren, Yan Rong, Mengru Lai, Jiamin Jin, Fei Huang, Liujian Ouyang, Feng Zhou, Heng‐Yu Fan, Yin‐Li Zhang, Songying Zhang   +18 more
wiley   +1 more source

CircTP53/USP10/p53 signaling Axis as a Novel Regulator of Progression and Prognosis of Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
The study identifies a novel circular RNA derived from the TP53 gene (circTP53), which is upregulated in HNSCC and correlates with poor patient prognosis. It demonstrates that circTP53 promotes HNSCC progression by interacting with USP10, stabilizing both proteins, enhancing deubiquitination of p53, and thereby influencing tumor growth, with its ...
Yin Wang, Fen Chang, Zinan Li, Chengcheng Duan, Xiangkai Sun, Siyu Wang, Dongmin Wei, Wenming Li, Ye Qian, Shengda Cao, Juan Zhao, Dapeng Lei   +11 more
wiley   +1 more source

Multimodal Investigation of Angiogenesis and Its Prevention by Small Compounds in a Zebrafish Cancer Model

Advanced Science, EarlyView.
A combined optical coherence tomography angiography and fluorescence imaging approach assesses tumor angiogenesis and drug effects in a novel zebrafish cancer model. By analyzing 3D vasculature data, the two imaging methods complement each other to quantify blood flow, vessel structure, and drug efficacy.
Marco Andreana, Ryan Sentosa, Caterina Sturtzel, Martin Pfister, René Werkmeister, Anna Schmitt, David Traver, Rainer Leitgeb, Wolfgang Drexler, Martin Distel, Angelika Unterhuber   +10 more
wiley   +1 more source

Intraflagellar transport delivers tubulin isotypes to sensory cilium middle and distal segments. [PDF]

, 2011
Sensory cilia are assembled and maintained by kinesin-2-dependent intraflagellar transport (IFT). We investigated whether two Caenorhabditis elegans α- and β-tubulin isotypes, identified through mutants that lack their cilium distal segments, are ...
Acar, Seyda, Brust-Mascher, Ingrid, Civelekoglu-Scholey, Gul, Hao, Limin, Lu, Yun, Prevo, Bram, Scholey, Jonathan M, Shaham, Shai, Thein, Melanie   +8 more
core  

Post‐Translational Modifications in Cilia and Ciliopathies

Advanced Science, EarlyView.
This review synthesizes current understanding of post‐translational modifications (PTMs) in ciliary proteins and emphasizes their roles in ciliary formation, homeostasis, and signaling. This review also discusses the implication of PTM dysregulation in ciliopathies and explores therapeutic strategies targeting PTM‐modifying enzymes.
Jie Ran, Jun Zhou
wiley   +1 more source