Cilostazol Modulates Autophagic Degradation of β-Amyloid Peptide via SIRT1-Coupled LKB1/AMPKα Signaling in Neuronal Cells. [PDF]
PLoS ONE, 2016 A neuroprotective role of autophagy mediates the degradation of β-amyloid peptide (Aβ) in Alzheimer's disease (AD). The previous study showed cilostazol modulates autophagy by increasing beclin1, Atg5 and LC3-II expressions, and depletes intracellular Aβ
So Youn Park +6 more
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Protective effects of cilostazol against hemorrhagic stroke: Current and future perspectives
Journal of Pharmacological Sciences, 2016 Cilostazol is a phosphodiesterase-3 inhibitor and is known to have pleiotropic effects including antiplatelet and vasodilatation effects and protective effects on endothelial cells.
Toshinori Takagi, Hideaki Hara
doaj +2 more sources
Safety of cilostazol in peripheral artery disease: a cohort from a primary healthcare electronic database [PDF]
BMC Cardiovascular Disorders, 2018 Background Cilostazol has been associated with spontaneous reports of cardiovascular adverse events and serious bleeding. The objective of this study is to determine the relative risk of cardiovascular adverse events or haemorrhages in patients with ...
Jordi Real +9 more
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Nano-Cilostazol Mitigates Cisplatin-Induced Nephrotoxicity in Rats via Modulation of Oxidative Stress, Apoptosis, Pyroptosis, and miRNA-155 Signaling [PDF]
AntioxidantsBackground: This study investigated the renoprotective potential of Nano-Cilostazol against cisplatin (CIS)-induced renal injury in male rats and explored its molecular mechanisms.
Hebatallah M. Saad +10 more
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Impact of cilostazol on clinical outcomes in lower extremity arterial disease patients after angioplasty: A real-world analysis. [PDF]
PLoS ONEBackgroundCilostazol has been shown to improve walking distance in patients with lower extremity arterial disease (LEAD) and may reduce restenosis after revascularization.
Hsien-Yuan Chang +5 more
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β-aminopropionitrile-induced thoracic aortopathy is refractory to cilostazol and sildenafil in mice. [PDF]
PLoS ONEThoracic aortopathies are life-threatening diseases including aneurysm, dissection, and rupture. Cilostazol, a phosphodiesterase (PDE) 3 inhibitor, and sildenafil, a PDE5 inhibitor, have been used clinically for peripheral arterial disease and erectile ...
Samuel C Tyagi +7 more
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CILO-CLOP Trial: Cilostazol Versus Clopidogrel in Acute Moderate and Moderate-to-Severe Ischemic Stroke: A Randomized Controlled Multicenter Trial [PDF]
Neurology and TherapyIntroduction All large studies evaluating the role of cilostazol versus other antiplatelet agents in stroke prevention have been conducted in Asia and included patients with minor stroke or transient ischemic attack (TIA). Ours is the first-ever trial to
Mohamed G. Zeinhom +12 more
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Comparative Study of Ex Vivo Antiplatelet Activity of Aspirin and Cilostazol in Patients with Diabetes and High Risk of Cardiovascular Disease [PDF]
Endocrinology and Metabolism, 2022 Background The role of aspirin in primary cardiovascular disease prevention in patients with diabetes remains controversial. However, some studies have suggested beneficial effects of cilostazol on cardiovascular disease in patients with diabetes.
Sangmo Hong +2 more
doaj +1 more source
PLoS ONE, 2022 ObjectiveTo evaluate the efficacy and safety of cilostazol, pentoxifylline, beraprost for intermittent claudication due to lower extremity arterial occlusive disease.MethodsRandomized controlled clinical trials were identified from PubMed, Scopus, EMbase,
Xinyu Liang +3 more
doaj +2 more sources