Results 61 to 70 of about 15,669 (253)

Beat‐to‐beat variability of ventricular repolarization reveals sex‐specific instability and proarrhythmic risk

The Journal of Physiology, EarlyView.
Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Daisuke Sato, Lorenzo Santini, Raffaele Coppini, Eleonora Grandi   +3 more
wiley   +1 more source

Platelet‐Activating Factor Pathway in Women With Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity

Obesity, Volume 34, Issue 5, Page 1056-1067, May 2026.
Increased hepatic PAFR expression in MASLD is associated with histological disease severity and may contribute to progression through platelet activation, whereas circulating Lp‐PLA2 levels lack discriminatory value as a noninvasive biomarker. ABSTRACT Objective This study aimed to investigate the platelet‐activating factor (PAF) pathway in obesity ...
Joan Duran‐Bertran, Helena Clavero‐Mestres, Razieh Mahmoudian, Sara Muñiz‐Piera, Carmen Aguilar, David Riesco, Javier Camaron, Salomé Martínez, Margarida Vives, Marta París, Fàtima Sabench, Teresa Auguet   +11 more
wiley   +1 more source

Premature Ventricular Contractions (PVCs) Induced by Administration of Cilostazol after Myocardial Infarction

Russian Open Medical Journal, 2013
Cilostazol is a phosphodiesterase III inhibitor, which was approved by FDA (food and drug administration) for intermittent claudication in 1999. What made it known to cardiologists is the Cilostazol for Restenosis Trial (CREST), in which cilostazol was ...
Lihua Zhong, Yanhui Gao, Xueqi Li, Shipeng Wei   +3 more
doaj  

Long-term cilostazol treatment reduces gliovascular damage and memory impairment in a mouse model of chronic cerebral hypoperfusion

Scientific Reports, 2017
Chronic cerebral hypoperfusion is a major cause of age-related vascular cognitive impairment. A well-characterised mouse model has shown that hypoperfusion results in gliovascular and white matter damage and impaired spatial working memory. In this study,
Akihiro Kitamura, Yasmina Manso, Jessica Duncombe, James Searcy, Juraj Koudelka, Margaret Binnie, Scott Webster, Ross Lennen, Maurits Jansen, Ian Marshall, Masafumi Ihara, Raj N. Kalaria, Karen Horsburgh   +12 more
doaj   +1 more source

Cilostazol Ameliorates Peripheral Neuropathic Pain in Streptozotocin-Induced Type I Diabetic Rats

Frontiers in Pharmacology, 2022
Background: Cilostazol is an antiplatelet agent with vasodilating, endothelial function restoration, and anti-inflammatory effects. This study aims to investigate the efficacy of oral cilostazol for preventing the development of diabetic peripheral ...
Kuang-I. Cheng, Kuang-I. Cheng, Hung-Chen Wang, Kuang-Yi Tseng, Kuang-Yi Tseng, Yi-Hsuan Wang, Chung-Yu Chang, Yi-Jing Chen, Chung-Sheng Lai, Dar-Ren Chen, Dar-Ren Chen, Lin-Li Chang, Lin-Li Chang, Lin-Li Chang, Lin-Li Chang   +14 more
doaj   +1 more source

Cilostazol for intermittent claudication [PDF]

Cochrane Database of Systematic Reviews, 2014
Peripheral arterial disease (PAD) affects between 4% and 12% of people aged 55 to 70 years, and 20% of people over 70 years. A common complaint is intermittent claudication (exercise-induced lower limb pain relieved by rest). These patients have a three- to six-fold increase in cardiovascular mortality.
Brown, Tamara, Forster, Rachel B, Cleanthis, Marcus, Mikhailidis, Dimitri P, Stansby, Gerard, Stewart, Marlene   +5 more
openaire   +6 more sources

Development of a Predictive Flow Through Cell Dissolution Method for Carbamazepine Modified‐Release Tablets

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 5, May 2026.
ABSTRACT Predictive in vitro dissolution methods are crucial for anticipating in vivo drug performance, particularly for poorly soluble drugs like carbamazepine. In vitro‐in vivo correlations (IVIVC) link dissolution characteristics to pharmacokinetics, facilitating bioequivalence studies and reducing reliance on clinical trials.
Laura Carvajal Barbosa, Sandra Milena Echeverry, Diana Marcela Aragón   +2 more
wiley   +1 more source

Associations of Weight Change With Changes in Calf Muscle Characteristics and Functional Decline in Peripheral Artery Disease. [PDF]

, 2019
Background Among people with lower extremity peripheral artery disease, obesity is associated with faster functional decline than normal weight. The association of weight loss with functional decline in peripheral artery disease is unknown.
Bazzano, Lydia A, Criqui, Michael H, Ferrucci, Luigi, Guralnik, Jack M, Kibbe, Melina R, Leeuwenburgh, Christiaan, McDermott, Mary M, Polonsky, Tamar S, Sufit, Robert L, Tian, Lu, Zhang, Dongxue   +10 more
core  

Hemisphere asymmetry of response to pharmacologic treatment in an Alzheimer’s disease mouse model

, 2016
The aim of this study was to examine hemisphere asymmetry of response to pharmacologic treatment in an Alzheimer’s disease mouse model using cilostazol as a chemical stimulus.
Al-Daghri, Nasser M., Carare, Roxana O., Garbis, Spiros D., Ihara, Masafumi, Manousopoulou, Antigoni, Saito, Satoshi, Yamamoto, Yumi   +6 more
core   +1 more source

Delayed CAVB After SP Ablation for AVNRT: Mechanistic Insights Into FP Injury and Pacing Decision‐Making

Pacing and Clinical Electrophysiology, Volume 49, Issue 5, Page 610-617, May 2026.
ABSTRACT As standard therapy for atrioventricular nodal re‐entrant tachycardia (AVNRT), radiofrequency ablation of the antegrade slow pathway (SP) is associated with a low risk of AV block. Delayed complete AV block (CAVB), however, is a rare but clinically challenging complication, particularly concerning permanent pacemaker decision‐making. A 79‐year‐
Nobuhiro Honda, Kiyohiro Ogawa, Kotaro Tasaki, Mio Hino, Taiki Kodama, Seigo Masuda   +5 more
wiley   +1 more source