ABSTRACT Retrograde recanalization of chronic total occlusion can be challenging for its association with a greater risk of device entrapment and fracture. Aggressive advancement of retrograde guidewire through tortuous collateral may increase the risk of guidewire fracture. Stent jailing technique can sometimes be adopted based on the location, length,
Ang Gao +6 more
wiley +1 more source
Validasi Metode Analisis Cilostazol Dalam Plasma in Vitro Secara Kromatografi Cair Kinerja Tinggi [PDF]
Cilostazol is an antiplatelet agent with the mechanism of action by inhibiting phos-phodiesterase III (PDE III). Referred to Food and Drug Administration(FDA),cilostazol is a drug recommended to be bioequivalence (BE) studied.
Estherina, C. (Christine) +2 more
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Oxidative stress and epigenetic regulation in ageing and age-related diseases [PDF]
Recent statistics indicate that the human population is ageing rapidly. Healthy, but also diseased, elderly people are increasing. This trend is particularly evident in Western countries, where healthier living conditions and better cures are available ...
Cencioni, Chiara +6 more
core +2 more sources
Contemporary Perspectives on J‐Wave Syndromes: An Expert Consensus Statement
ABSTRACT J‐wave syndromes (JWS)—comprising Brugada syndrome (BrS) and early repolarization syndrome (ERS)—are important causes of malignant ventricular arrhythmias and sudden cardiac death in patients whose hearts appear structurally normal. Since the 2016 consensus, advances in genetics, pathophysiology, and therapy have redefined both understanding ...
Koonlawee Nademanee +22 more
wiley +1 more source
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo +11 more
wiley +1 more source
Cilostazol, a type-3 phosphodiesterase (PDE3) inhibitor, has become widely used as an antiplatelet drug worldwide. A recent second Cilostazol Stroke Prevention Study demonstrated that cilostazol is superior to aspirin for prevention of stroke after an ...
Kenji Hashimoto, Tamaki Ishima
doaj +1 more source
The role of p53 in atherosclerosis [PDF]
Although the role of the tumour suppressor gene p53 is well known in cancer, recent studies have highlighted a fundamental role for p53 in regulating cells in the advanced atherosclerotic plaque, the major cause of heart attacks and stroke. In particular,
Bennett, M., Mercer, J.R.
core +1 more source
Duplicate Prescription Patterns in Patients With Substance Use Disorders
ABSTRACT This study sought to investigate the frequency and characteristics of duplicate prescriptions (DPs) in psychiatric inpatients with substance use disorders using a DP classification that differentiates between appropriate DPs (ADPs) and potentially inappropriate DPs (PIDPs). The study was conducted as a monocentric retrospective cross‐sectional
Johannes Heck +8 more
wiley +1 more source
Concurrent Treatment with Taxifolin and Cilostazol on the Lowering of β-Amyloid Accumulation and Neurotoxicity via the Suppression of P-JAK2/P-STAT3/NF-κB/BACE1 Signaling Pathways. [PDF]
Taxifolin is a potent flavonoid that exerts anti-oxidative effect, and cilostazol increases intracellular cAMP levels by inhibiting phosphodiesterase 3 that shows antiinflammatory actions.
So Youn Park +5 more
doaj +1 more source
IMPACTO DEL DIAGNÓSTICO OPORTUNO DE ENFERMEDAD ARTERIAL PERIFERICA VS INSUFICIENCIA VENOSA PERIFÉRICA EN PACIENTES CON DIABETES MELLITUS TIPO 2 DEL HOSPITAL REGIONAL TLALNEPANTLA ISSEMYM [PDF]
RESUMEN Introducción: El diagnóstico de la enfermedad arterial periférica no se realiza de manera oportuna por parte de los médicos de primer nivel, y el diagnóstico que realizan de manera inicial es de insuficiencia venosa periférica, lo que ...
BRITO HERNANDEZ, ANTONIO DE JESUS +1 more
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