Results 1 to 10 of about 84,748 (209)
Nature Reviews Molecular Cell Biology, 2013 Surveillance mechanisms, such as the spindle assembly checkpoint (SAC) have evolved to ensure chromosome segregation fidelity. When these quality control mechanisms fail, aneuploidy ensues. This condition of an abnormal chromosome number has long been associated with death, disease and developmental abnormalities.
Kristin A Knouse +2 more
exaly +3 more sources
The Journal of Cell Biology, 2008 Aneuploidy and chromosome instability (CIN) are hallmarks of the majority of solid tumors, but the relationship between them is not well understood. In this issue, Thompson and Compton (Thompson, S.L., and D.A. Compton. 2008. Examining the link between chromosomal instability and aneuploidy in human cells. J. Cell. Biol.
Desai, A, Yuen, KW
openaire +4 more sources
Cancer: CINful Centrosomes [PDF]
Current Biology, 2009 The regulation of centrosome number is lost in many tumors and the presence of extra centrosomes correlates with chromosomal instability. Recent work now reveals how extra centrosomes cause chromosome mis-segregation in tumor cells.
Bakhoum, Samuel F., Compton, Duane A.
openaire +2 more sources
The CINs of the centromere [PDF]
Biochemical Society Transactions, 2013 Replication stress is a significant contributor to genome instability. Recent studies suggest that the centromere is particularly susceptible to replication stress and prone to rearrangements and genome damage, as well as chromosome loss. This effect is enhanced by loss of heterochromatin.
openaire +2 more sources
Development of an Artificial Intelligence Web Application for Predicting Chemotherapy-Induced Neutropenia in Patients With Non-Small Cell Lung Cancer: A Prospective Study. [PDF]
Cancer MedABSTRACT Objective This study aimed to develop an artificial intelligence (AI) web application for predicting chemotherapy‐induced neutropenia (CIN) in patients with non‐small cell lung cancer (NSCLC). Methods We conducted a prospective study including 310 patients who underwent 1047 chemotherapy cycles with NSCLC patients between 2019 and 2024 from ...
Zhang J +11 more
europepmc +2 more sources
BioEssays, 2018 Chromosomal instability (CIN) and aneuploidy are similar concepts but not synonymous. CIN is the process that leads to chromosome copy number alterations, and aneuploidy is the result. While CIN and resulting aneuploidy often cause growth defects, they are also selected for in cancer cells.
Schukken, Klaske M., Foijer, Floris
openaire +1 more source
Fanning the flames of CIN [PDF]
Cell Cycle, 2015 A Sophia, Gayek, Ryoma, Ohi
openaire +2 more sources
Predictive value of the uric acid-to-albumin ratio for contrast-induced nephropathy after percutaneous coronary intervention and construction of a clinical prediction model in patients with coronary artery disease. [PDF]
Front Cardiovasc MedZhu Y +5 more
europepmc +1 more source
Roxadustat attenuates contrast-induced acute kidney injury potentially mediated via the Nrf2/HO-1 signaling pathway. [PDF]
Ren FailWang J, E JW, Zhang J.
europepmc +1 more source