Results 211 to 220 of about 143,488 (304)

Optimisation of a Novel Class of DNA Gyrase Inhibitors to Improve Antibacterial Activity

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
This article describes efforts to increase the antibacterial activity of a recently reported class of novel DNA gyrase inhibitors known as the isoquinoline sulphonamides by improving their uptake in bacterial cells. As antibiotic resistance continues to rise, the need for new antibacterials is clear.
Meg I. Ferguson, Cerissa C. van Walstijn, Vladyslav Lysenko, Marta A. Wilbrink, David Alencar Araripe, Jeroen M. Punt, Mario van der Stelt, Willem Jespers, Paolo Innocenti, Nathaniel I. Martin   +9 more
wiley   +1 more source

A Rare Case of Salmonella Typhimurium Prosthetic Joint Infection in Total Hip Arthroplasty in a Young Patient with Long-term Corticosteroid Therapy. [PDF]

J Orthop Case Rep
Selvamalaiyarasan S, Harshavardhan JKG, Tavfiq MM.   +2 more
europepmc   +1 more source

Targeting of Staphyloxanthin and α‐Hemolysin by Natural Compound L‐Malic Acid Suppresses Staphylococcus aureus Virulence

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
L‐malic acid, a natural TCA cycle intermediate, attenuates the virulence of Staphylococcus aureus through dual metabolic and regulatory mechanisms. It redirects central carbon flux away from the mevalonate pathway and inhibits the key enzyme CrtO, suppressing staphyloxanthin biosynthesis and impairing bacterial resistance to oxidative stress ...
Li Shen, Bingjie Wang, Jinjin Yang, Xinru Yuan, Zhixuan Chen, Can Yang, Jiana Fu, Haojin Gao, Weihua Han, Junhong Shi, Fangyou Yu, Jingyi Yu   +11 more
wiley   +1 more source

A comprehensive study on enrofloxacin residue depletion in five chicken breeds. [PDF]

Poult Sci
Chen D, Wang C, Liu Y, Ma L, Zhang J, Gao Y, Tang X.   +6 more
europepmc   +1 more source

Exploring the Potential of Zero‐Dimensional Carbon Nanomaterials in Photoluminescent, Electrochemiluminescent and Electrochemical Sensors

Advanced Materials Interfaces, Volume 13, Issue 11, 9 June 2026.
Zero‐dimensional carbon nanomaterials are presented as multifunctional platforms linking structure, property, and sensing performance. Surface engineering and heteroatom doping modulate electron‐transfer and luminescent behavior, enabling electrochemical, photoluminescent, and electrochemiluminescent detection. Fundamental design principles, analytical
Gustavo Martins, Jeferson Luiz Gogola, Ava Gevaerd, Cristiane Kalinke, Paulo Roberto de Oliveira, Fabio Roberto Caetano, Bruno Campos Janegitz, Márcio Fernando Bergamini, Luiz Humberto Marcolino‐Junior   +8 more
wiley   +1 more source

Epidemiological cutoff values of the novel pleuromutilin derivative PFAM and conventional antimicrobials against Mycoplasma gallisepticum in Guangdong, China. [PDF]

BMC Vet Res
Zhang F, Chen B, Zhou X, Chen W, Deng L, Ding H.   +5 more
europepmc   +1 more source

Stimuli‐Responsive Crosslinked Chitosan/PVP/PEG Hydrogel Networks for Targeted Drug Delivery and Antimicrobial Performance

Analytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT In this study, a unique pH‐sensitive PEG/C/PVA hydrogel based on chitosan (C), polyvinyl propylene (PVP) and polyethylenglycol (PEG) crosslinked with tetraethyl orthosilicate (TEOS) was fabricated. This PEG/C/PVA hydrogel was designed to deliver different drugs with distinct release profiles, including diclofenac sodium and ciprofloxacin, and ...
Danial Mazhar, Sumra Afzal, Safia Hassan, Zahid Imran, Shabana Mehreen   +4 more
wiley   +1 more source

Efficacy of lytic bacteriophages isolated from sewage-treatment plants in Mbarara district, Uganda against ciprofloxacin-resistant Salmonella Typhi in a mice infection model. [PDF]

BMC Infect Dis
Bindyo PN, Ibrahim N, Nabona J, Udom GJ, Nakavuma JL.   +4 more
europepmc   +1 more source

Severe Lactic Acidosis in Decompensated Cirrhosis Despite Nondiagnostic Imaging

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Lactic acidosis is a strong predictor of mortality in cirrhosis, reflecting both impaired hepatic clearance and systemic tissue hypoxia. We describe a 38‐year‐old man with decompensated alcohol‐associated cirrhosis who developed severe lactic acidosis despite stable hemodynamics and initially nondiagnostic vascular imaging.
Nakul Ganju, Chibuzor Victor Nwachukwu, Juan Santiago‐Gonzalez, Shaharyar Naeem, Nicholas Azinge, Adeyinka O. Laiyemo   +5 more
wiley   +1 more source