Results 41 to 50 of about 469 (131)

Pharmacokinetics and exposure–safety relationship of ciprofol for sedation in mechanically ventilated patients in the intensive care unit

CPT: Pharmacometrics &Systems Pharmacology, Volume 13, Issue 5, Page 823-836, May 2024.
Abstract Ciprofol (HSK3486) is a newly developed, highly selective γ‐aminobutyric acid‐A (GABAA) receptor potentiator that is recently approved for a new indication of sedation for patients in the intensive care unit (ICU) in China. This analysis aimed to characterize the population pharmacokinetics (PopPKs) of ciprofol and evaluate the relationship of
Lu Liu, Kun Wang, Zhongyi Sun, Pangke Yan, Mengyue Hu, Xiao Liu, Meixia Chen, Nan Wu, Xiaoqiang Xiang   +8 more
wiley   +1 more source

Exploring Ciprofol Alternatives: A Comprehensive Review of Intravenous Anesthesia Options

Cureus
Ciprofol is a recently developed, short-acting γ-aminobutyric acid receptor agonist sedative that is more potent than propofol. Still, there have been few clinical studies of this agent to date. This review explores alternative intravenous anesthesia options to ciprofol, considering their pharmacology, clinical efficacy, safety profile, and practical ...
Durai Samy, Nandha kumar, Taksande, Karuna   +1 more
openaire   +2 more sources

The efficacy and safety of ciprofol versus propofol in patients undergoing painless hysteroscopy: a randomized, double-blind, controlled trial

BMC Anesthesiology
Background Studies have reported that ciprofol has the advantage of reducing injection pain compared to propofol during gastroscopy, colonoscopy, and fiberoptic bronchoscopy.
Aijun Li, Ning Li, Lei Zhu, Zige Xu, Yifan Wang, Junjie Li, Gerong Zhang   +6 more
doaj   +1 more source

The efficacy and safety of ciprofol use for the induction of general anesthesia in patients undergoing gynecological surgery: a prospective randomized controlled study

BMC Anesthesiology, 2022
Background Ciprofol is a recently developed, short-acting γ-aminobutyric acid receptor agonist sedative that is more potent than propofol, but there have been few clinical studies of this agent to date.
Ben-zhen Chen, Xin-yu Yin, Li-hua Jiang, Jin-hui Liu, Yan-yan Shi, Bi-ying Yuan   +5 more
doaj   +1 more source

Pharmacological Insights and Clinical Applications of Ciprofol: A Narrative Review

Cureus
Ciprofol (HSK3486) is a novel intravenous anaesthetic developed as an alternative to propofol, offering a safer and more effective option in anaesthesia. It works primarily by modulating the gamma-aminobutyric acid (GABA) receptors in the central nervous system, leading to sedation and hypnosis.
Petkar, Shubham, Bele, Amol, Priya, Vishnu, Bawiskar, Dushyant   +3 more
openaire   +2 more sources

ED50 of ciprofol combined with sufentanil for fiberoptic bronchoscopy of different patient populations with pulmonary tuberculosis

BMC Anesthesiology
Background Ciprofol is a promising sedative. This study aims to explore the median effective dose (ED50) of ciprofol in inhibiting responses to fiberoptic bronchoscopy in patients with pulmonary tuberculosis (PTB) of different genders and ages when ...
Min Pan, Weidong Liu, Zhixin Zhang, Tong Li, Weibin Xie   +4 more
doaj   +1 more source

The potency-ratio of ciprofol and propofol under procedural sedation and anesthesia for outpatient hysteroscopy during cervical dilation: a study using up-and-down sequential allocation method

BMC Anesthesiology
Background Ciprofol(HSK3486) is a novel 2,6-disubstituted phenol derivate, a short-acting intravenous sedative, which has similar efficacy characteristics as propofol with less incidence of side effect.
Lin Jin, Cui-cui Jiao, Xiao-ping Chen, Li-hong Sun, Yu Zhang, Xin-zhong Cheng, Jin-zhong Wang, Xiao-wei Qian   +7 more
doaj   +1 more source

Ciprofol as compared to propofol for sedation and general anesthesia: a systematic review of randomized controlled trials

Journal of Anesthesia, Analgesia and Critical Care
Background Propofol is the most commonly used hypnotic agent used during sedation and general anesthesia (GA) practice, offering faster recovery compared to benzodiazepines.
Jessica M. Currò, Cristina Santonocito, Federica Merola, Simone Messina, Marco Sanfilippo, Serena Brancati, Filippo Drago, Filippo Sanfilippo   +7 more
doaj   +1 more source

Median Effective Dose of Ciprofol Combined With Sufentanil for Inhibiting the Upper Gastrointestinal Endoscopic Placement Reaction in Elderly Patients

Dose-Response
Objective Ciprofol is a new sedative anesthetic drug that can be used for gastrointestinal endoscopy and induction of general anesthesia, but the appropriate dosage for use in elderly patients has not been determined. Sufentanil is a commonly used opioid
Haojing Xiong, Hechen Xu, Yang Yang, Bailong Hu, Ke Jiang, Xiaohua Zou   +5 more
doaj   +1 more source

The 90% effective dose of ciprofol and propofol with S-ketamine for painless abortion: a randomized, double-blind, sequential dose-finding trial

Therapeutic Advances in Drug Safety
Background: Unlike the propofol–opioids combination, a single dose of S-ketamine with propofol achieves the same anesthetic effects while effectively minimizing adverse reactions in painless abortion.
Qiang Tao, Qiao Shi, Tao Xu, Shanshan Ye
doaj   +1 more source