Results 61 to 70 of about 469 (131)

Ciprofol- a game changing intravenous anesthetic or another experimental drug!

Saudi Journal of Anaesthesia, 2022
Abhijit Nair, Suresh Seelam
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Effect of Lidocaine on Ciprofol Dosage and Efficacy in Patients Who Underwent Gastroscopy Sedation

Medical Science Monitor Basic Research
BACKGROUND Intravenous ciprofol is a short-acting sedative with minimal respiratory and circulatory suppression and limited analgesia. Intravenous lidocaine provides analgesia during surgical procedures. This study included 70 patients who underwent gastroscopy with analgesia and aimed to evaluate the effects of intravenous lidocaine on the dose of ...
Han, Yang, Zhang, Baohua, Jin, Li, Yu, Zhiyang, He, Huan   +4 more
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Comparative effective dose of ciprofol and propofol in suppressing cardiovascular responses to tracheal intubation

Scientific Reports
Abstract Ciprofol, a novel γ-aminobutyric acid receptor agonist, outperforms propofol with minimal cardiovascular effects, higher potency, reduced injection pain, and a broader safety margin. Despite these advantages, ciprofol’s clinical research is still emerging. This study compares the median effective dose (ED
Min Liao, Xiao-Ru Wu, Jia-Ning Hu, Xing-Zhou Lin, Tang‑yuan‑meng Zhao, Hu Sun   +5 more
openaire   +3 more sources

Early sedation using ciprofol for intensive care unit patients requiring mechanical ventilation: a pooled post-hoc analysis of data from phase 2 and phase 3 trials

Annals of Intensive Care
Background Ciprofol was approved for use in intensive care unit (ICU) patients requiring sedation during mechanical ventilation in July 2022. A pooled post-hoc analysis of phase 2 and phase 3 trials was conducted primarily to explore hypotension-free ...
Yongjun Liu, Lingyun Zuo, Xiaoyun Li, Yao Nie, Chuanxi Chen, Ning Liu, Minying Chen, Jianfeng Wu, Xiangdong Guan   +8 more
doaj   +1 more source

Efficacy and safety of ciprofol for sedation/anesthesia in patients undergoing hysteroscopy: a prospective, randomized, non-inferiority trial

Annals of Medicine
Introduction Propofol is the preferred sedative for painless hysteroscopy and other procedures due to its fast onset and short duration. However, its limitations, including injection pain, respiratory depression, blood pressure decline, and bradycardia ...
Shi Cheng, Haixuan Wu, Zhongqi Liu, Dan Liu, Minghui Cao, Ganglan Fu   +5 more
doaj   +1 more source

Enhanced hemodynamic stability and patient satisfaction with ciprofol-remifentanil versus propofol-remifentanil for sedation in shorter-duration fiberoptic bronchoscopy: a prospective, randomized, double-blind study

Frontiers in Medicine
ObjectiveThis study aimed to compare the efficacy and safety of ciprofol-remifentanil versus propofol-remifentanil in patients undergoing fiberoptic bronchoscopy (FOB).MethodsIn this prospective, randomized, double-blind, non-inferiority trial, 209 ...
Jia Nie, Yongguo Zhang, Yan Wang, Liang Fang, Huanhuan Ma, Yu Zhang, Hai-ying Wang   +6 more
doaj   +1 more source

Ciprofol Regulates the Activity of Mitochondrial Respiratory Chain Complex I During Cerebral Ischemia-Reperfusion by Targeting Flavin Mononucleotide: A Metabolomic Study

Journal of Integrative Neuroscience
Background and Purpose: Ciprofol, a novel intravenous anesthetic, has been shown to exert protective effects against ischemic stroke, a leading cause of death and disability; however, its molecular mechanisms remain unclear. This study
Jixin Chen, Guoyou Chen, Yueheng Wu, Shuai Liu, Yifan Ma, Maonan Liu, Wei Yu   +6 more
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Comparison of Ciprofol-Based and Propofol-Based Total Intravenous Anesthesia on Microvascular Decompression of Facial Nerve with Neurophysiological Monitoring: A Randomized Non-Inferiority Trial

Drug Design, Development and Therapy
Tao Zhu,1 Fang Kang,1 Ming-Ming Han,1 Fang He,2 Sen Jiang,2 Li-Na Hao,1 Xiang Huang,1 Juan Li1 1Department of Anesthesiology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China ...
Zhu T, Kang F, Han MM, He F, Jiang S, Hao LN, Huang X, Li J   +7 more
doaj  

The novel ciprofol versus propofol during gastroenteroscopy in Chinese patients: a meta-analysis

Frontiers in Medicine
IntroductionGastrointestinal endoscopic interventions have become a routine practice in healthcare institutions. Propofol has been the most preferred general anesthetic agent for gastrointestinal endoscopic interventions. Ciprofol is a novel compound that has been approved by the China Medical Products Administration for sedation during ...
Xiaoyan Liang, Qing Feng, Guozhen Li, Tong Liu, Lingyuan Zeng, Yang Xiao, Kun Zhang   +6 more
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Effective doses of ciprofol combined with alfentanil in inhibiting responses to gastroscope insertion, a prospective, single-arm, single-center study

BMC Anesthesiology
Background Ciprofol is a novel intravenous sedative and anesthetic. Studies have shown that it features a rapid onset of action, a fast recovery time, slight inhibition of respiratory and cardiovascular functions, and a low incidence of adverse reactions.
Xiaoru Wu, Min Liao, Xingzhou Lin, Jianing Hu, Tangyuanmeng Zhao, Hu Sun   +5 more
doaj   +1 more source