Results 161 to 170 of about 178,041 (266)

Progression of Motor and Cognitive Functions in Isolated REM Sleep Behavior Disorder: A 7‐Year Prospective Matched Cohort Study

open access: yesMovement Disorders, EarlyView.
Abstract Background Although clinical markers (eg, motor and cognitive impairment) in isolated rapid eye movement sleep behavior disorder (iRBD) are associated with faster phenoconversion, their longitudinal trajectory patterns (linear or nonlinear) remain unclear.
Li Zhou   +17 more
wiley   +1 more source

Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino   +3 more
wiley   +1 more source

Toward Free‐Breathing Renal CEST MRI: Preclinical Evaluation of a Novel Prospective Respiratory Triggering Approach

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Endogenous renal chemical exchange saturation transfer (CEST) imaging enables contrast‐agent‐free assessment of renal metabolism but is highly sensitive to respiratory motion. Existing approaches, such as timed breathing, require high patient compliance or preclinical mechanical ventilation, limiting clinical translation.
Patrik Jan Gallinnis   +12 more
wiley   +1 more source

Age and Nocturnal Polyuria in Nocturia: A Multicenter Voiding Diary Cohort Study

open access: yesNeurourology and Urodynamics, EarlyView.
ABSTRACT Introduction Although the prevalence of nocturnal polyuria (NP) increases with age, the mechanisms underlying age‐related changes in voiding patterns and the daytime–nighttime distribution of urine volume remain unclear. Given that the severity of nocturia and bladder function may differ across age groups, age‐specific voiding profiles require
Kota Kawase   +15 more
wiley   +1 more source

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