Results 181 to 190 of about 396,990 (333)

Functional regression with intensively measured longitudinal outcomes: a new lens through data partitioning

open access: yesCanadian Journal of Statistics, EarlyView.
Abstract Modern longitudinal data from wearable devices consist of biological signals at high‐frequency time points. Distributed statistical methods have emerged as a powerful tool to overcome the computational burden of estimation and inference with large data, but methodology for distributed functional regression remains limited.
Cole Manschot, Emily C. Hector
wiley   +1 more source

Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Food Effect of Bexicaserin in Healthy Participants: A First‐in‐Human Randomized, Double‐Blind, Placebo‐Controlled Single Ascending Dose Escalation Phase 1 Study

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract Bexicaserin (LP352) is a selective 5‐hydroxytryptamine 2C (5‐HT2C) superagonist in development for the treatment of seizures in developmental and epileptic encephalopathies (DEEs). This double‐blind, placebo‐controlled, single ascending dose (SAD) Phase 1 study aimed to assess the safety, tolerability, and pharmacokinetic (PK) and ...
Rosa Chan   +6 more
wiley   +1 more source

Circadian rhythms and the effects of long-distance flights. [PDF]

open access: green, 1968
Stanley R. Mohler   +2 more
openalex   +1 more source

Influence of environment and mineralogy on euendolithic microboring patterns

open access: yesThe Depositional Record, EarlyView.
Field experiments at Little Ambergris Cay reveal that euendolithic microorganisms preferentially bore carbonate substrates based on mineralogy, sea water saturation and trace metal content. Results highlight night‐time dissolution activity and mineralogical preferences, shedding light on the ecological and evolutionary drivers of bioerosion and their ...
Tyler Lincoln   +3 more
wiley   +1 more source

Circadian Clock: A Regulator of Immunity in Autoimmune Diseases. [PDF]

open access: yesImmun Inflamm Dis
Wu YJ   +4 more
europepmc   +1 more source

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