Results 61 to 70 of about 396,990 (333)

Evaluation of Changes in Social Isolation and Loneliness with Incident Cardiovascular Events and Mortality

Journal of Epidemiology and Global Health
Background It remains unknown how the patterns of change of social isolation and loneliness are associated with the onset of cardiovascular disease (CVD) and mortality.
Yilin Chen, Huachen Xue, Yu Nie, Yujing Zhou, Sizhi Ai, Yaping Liu, Jihui Zhang, Yannis Yan Liang   +7 more
doaj   +1 more source

Nerve growth factor, brain-derived neurotrophic factor, and the chronobiology of mood: a new insight into the "neurotrophic hypothesis" [PDF]

, 2015
The light information pathways and their relationship with the body rhythms have generated a new insight into the neurobiology and the neurobehavioral sciences, as well as into the clinical approaches to human diseases associated with disruption of ...
IANNITELLI, ANGELA, Quartini, Adele, Tirassa, Paola   +2 more
core   +2 more sources

LOXHD1 and RHOB Expression by Monocytes Predicts Progressive Systemic Sclerosis associated Interstitial Lung Disease

Arthritis Care &Research, Accepted Article.
Objective A leading cause of death among scleroderma (SSc) patients, interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M Padilla, Robert Lafyatis, Kevin F Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J Kass   +13 more
wiley   +1 more source

Analysis of Saccharomyces cerevisiae Circadian Rhythms in Continuous Culture [PDF]

, 2012
The circadian rhythm is a roughly 24-hour cycle in the physiological processes of organisms. There have been many studies on the circadian rhythms in other model organisms, but not in Saccharomyces cerevisiae. To study the rhythm in S.
Kohner, Melissa, Lyons, Carlton, Zager, Lauren   +2 more
core   +2 more sources

Rodent models for the analysis of tissue clock function in metabolic rhythms research [PDF]

, 2017
The circadian timing system consists on a distributed network of cellular clocks that together coordinate 24-h rhythms of physiology and behavior. Clock function and metabolism are tightly coupled, from the cellular to the organismal level.
Astiz, Mariana, Leinweber, Brinja, Oster, Henrik, Tsang, Anthony H.   +3 more
core   +2 more sources

Circadian control of interferon-sensitive gene expression in murine skin. [PDF]

, 2020
The circadian clock coordinates a variety of immune responses with signals from the external environment to promote survival. We investigated the potential reciprocal relationship between the circadian clock and skin inflammation.
Andersen, Bogi, Dragan, Morgan, Greenberg, Elyse Noelani, Gudjonsson, Johann E, Jin, Suoqin, Marshall, Michaela Ellen, Nie, Qing, Takahashi, Joseph S, Tsoi, Lam C, Venkatesh, Sanan   +9 more
core   +2 more sources

Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

Advanced Healthcare Materials, EarlyView.
This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla, Vincenzo Verdi, Willemijn de Voogt, Mariona Estapé Sentí, Arnold C. Koekman, Julian Rietveld, Sven van Kempen, Qiangbing Yang, Juliette van Merris, Guido Jenster, Martin E. van Royen, Marcel H. Fens, Sander A. A. Kooijmans, Wytske M. van Weerden, Guillaume van Niel, Pieter Vader, Raymond M. Schiffelers   +16 more
wiley   +1 more source

Time of Day and Sleep Deprivation Effects on Risky Decision Making

Clocks & Sleep
Previous research has revealed that daily variations in human neurobehavioral functions are driven in part by the endogenous circadian system. The objective of this study was to explore whether there exists a circadian influence on performance regarding ...
Noelia Ruiz-Herrera, Mia Friedman, Melissa A. St. Hilaire, Arturo Arrona-Palacios, Charles A. Czeisler, Jeanne F. Duffy   +5 more
doaj   +1 more source

Circadian Clocks and Pregnancy [PDF]

Frontiers in Endocrinology, 2014
The recognition that 24-h rhythmic processes (“circadian”) underlie many endocrine functions has added a fascinating new temporal dimension to our appreciation of their complexity. Research from various laboratories has revealed circadian gene expression in multiple tissues in the reproductive system of non-pregnant and pregnant mammals.
openaire   +4 more sources

Seeing inside the Body Using Wearable Sensing and Imaging Technologies

Advanced Healthcare Materials, EarlyView.
This review explores wearable technologies for noninvasive internal health monitoring. It categorizes approaches into indirect sensing (e.g., bioelectrical and biochemical signals) and direct imaging (e.g., wearable ultrasound and EIT), highlighting multimodal integration and system‐level innovation toward personalized, continuous healthcare.
Sumin Kim, Seunghun Han, Sehwan Park, Jahyun Koo   +3 more
wiley   +1 more source