Results 51 to 60 of about 376,159 (303)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Reduced expression of the PER2 protein contributes to β₁-AA-induced cardiac autophagy rhythm disorders

Acta Biochimica et Biophysica Sinica
Heart failure may be linked to fluctuations in the rhythm of autophagy in cardiomyocytes throughout the day. Circadian rhythms depend on the regulation of core biological clock proteins, with PER2 playing a crucial role.
Li Pengjia, Feng Jiayan, Guo Jiao, Xue Jin, Li Yang, Wen Shiyuan, Wang Xiaohui, Liu Huirong, Wang Li   +8 more
doaj   +1 more source

Multi-omics profiling reveals rhythmic liver function shaped by meal timing

Nature Communications, 2023
Post-translational modifications (PTMs) couple feed-fast cycles to diurnal rhythms. However, it remains largely uncharacterized whether and how meal timing organizes diurnal rhythms beyond the transcriptome.
Rongfeng Huang, Jianghui Chen, Meiyu Zhou, Haoran Xin, Sin Man Lam, Xiaoqing Jiang, Jie Li, Fang Deng, Guanghou Shui, Zhihui Zhang, Min-Dian Li   +10 more
doaj   +1 more source

Objective Assessment of Daytime Napping and Incident Heart Failure in 1140 Community‐Dwelling Older Adults: A Prospective, Observational Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Disrupted nighttime sleep has been associated with heart failure (HF). However, the relationship between daytime napping, an important aspect of sleep behavior commonly seen in older adults, and HF remains unclear. We sought to investigate the
Peng Li, Arlen Gaba, Patricia M. Wong, Longchang Cui, Lei Yu, David A. Bennett, Aron S. Buchman, Lei Gao, Kun Hu   +8 more
doaj   +1 more source

Rhythms of Locomotion Expressed by Limulus polyphemus, the American Horseshoe Crab: II. Relationship to Circadian Rhythms of Visual Sensitivity [PDF]

, 2008
In the laboratory, horseshoe crabs express a circadian rhythm of visual sensitivity as well as daily and circatidal rhythms of locomotion. The major goal of this investigation was to determine whether the circadian clock underlying changes in visual ...
Bedford, Lisa, Chabot, Christopher C., Watson, Winsor H., III   +2 more
core   +3 more sources

Associations of Sleep and Shift Work With Osteoarthritis Risk

Arthritis Care &Research, EarlyView.
Objective Daily rhythms may be critical for maintaining homeostasis of joint tissues. We aimed to investigate the relationships among circadian clock disruption, sleep, and osteoarthritis (OA) risk in humans. Methods In the UK Biobank, a prospective 500,000–person cohort, we evaluated associations among sleep duration, sleeplessness/insomnia, and shift
Elizabeth L. Yanik, Abigail Bridgeman, Erik D. Herzog, Vy Pham, Bradley A. Evanoff, Farshid Guilak   +5 more
wiley   +1 more source

Research on left atrial appendage thrombogenic milieu prediction model in patients with nonvalvular atrial fibrillation based on machine learning algorithm

BMC Cardiovascular Disorders
Objective To establish a machine-learning model of left atrial appendage thrombogenic milieu (LAATM) in patients with nonvalvular atrial fibrillation (NVAF), and analyze the corresponding risk factors to guide clinical decision-making.
Ling Song, Xiaoqi Niu, Binbin Wang, Xiang Xu, Chen Wan, Feng Liu, Xizhi Tang, Wen Yan, Liping Liu, Zhiyuan Song, Huakang Li   +10 more
doaj   +1 more source

Sake yeast induces the sleep-promoting effects under the stress-induced acute insomnia in mice

Scientific Reports, 2021
Sleep deprivation induces adverse effects on the health, productivity, and performance. The individuals who could not get enough sleep temporarily experience the symptoms of an induced acute insomnia. This study investigated the efficacy of sake yeast in
Shohei Nishimon, Noriaki Sakai, Seiji Nishino   +2 more
doaj   +1 more source

Circadian Rhythm in Yeast [PDF]

, 2012
Circadian rhythms are found in a variety of organisms and are involved in controlling activity of the organism. However, a circadian rhythm for yeast has not been discovered yet.
Borchert, Michael, Yablonowski, Jake
core   +1 more source

Metabolic Effects of Bariatric Surgery in Mouse Models of Circadian Disruption [PDF]

, 2015
Background/Objectives: Mounting evidence supports a link between circadian disruption and metabolic disease. Humans with circadian disruption (for example, night-shift workers) have an increased risk of obesity and cardiometabolic diseases compared with ...
Arble, Deanna M., Sandoval, Darleen A., Seeley, Randy J., Turek, Fred W., Woods, Stephen C.   +4 more
core   +3 more sources