Psychological Screening for Exceptional Environments: Laboratory Circadian Rhythm and Sleep Research
Clocks & Sleep, 2020 Selecting participants who constitute a representative sample while protecting them from potential adverse outcomes is a concern for clinical researchers.
Stephen A. Amira +4 more
doaj +1 more source
Mutation of Arabidopsis SPLICEOSOMAL TIMEKEEPER LOCUS1 Causes Circadian Clock Defects [PDF]
, 2012 The circadian clock plays a crucial role in coordinating plant metabolic and physiological functions with predictable environmental variables, such as dusk and dawn, while also modulating responses to biotic and abiotic challenges.
Brown, John WS +5 more
core +1 more source
The retinal ipRGC-preoptic circuit mediates the acute effect of light on sleep
Nature Communications, 2021 The preoptic area (POA) is critical for sleep regulation but its role in acute, non-circadian, light effects on sleep are unclear. The authors show that intrinsically photosensitive retinal ganglion cells provide substantial input into the POA and ...
Ze Zhang +3 more
doaj +1 more source
Solving the mystery of human sleep schedules one mutation at a time. [PDF]
, 2013 Sleep behavior remains one of the most enigmatic areas of life. The unanswered questions range from "why do we sleep?" to "how we can improve sleep in today's society?" Identification of mutations responsible for altered circadian regulation of human ...
Fu, Ying-Hui +2 more
core +1 more source
Accuracy of Three Commercial Wearable Devices for Sleep Tracking in Healthy Adults
SensorsSleep tracking by consumers is becoming increasingly prevalent; yet, few studies have evaluated the accuracy of such devices. We sought to evaluate the accuracy of three devices (Oura Ring Gen3, Fitbit Sense 2, and Apple Watch Series 8) compared to the ...
Rebecca Robbins +10 more
doaj +1 more source
Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters.
, 2019 Many physiological processes exhibit circadian rhythms driven by cellular clocks composed of interlinked activating and repressing elements. To investigate temporal regulation in this molecular oscillator, we combined mouse genetic approaches and ...
Budak, H. +4 more
core +1 more source
Voluntary exercise can strengthen the circadian system in aged mice [PDF]
, 2013 Consistent daily rhythms are important to healthy aging according to studies linking disrupted circadian rhythms with negative health impacts. We studied the effects of age and exercise on baseline circadian rhythms and on the circadian system's ability ...
A Davidson +74 more
core +2 more sources
NREM delta power and AD-relevant tauopathy are associated with shared cortical gene networks
Scientific Reports, 2021 Reduced NREM sleep in humans is associated with AD neuropathology. Recent work has demonstrated a reduction in NREM sleep in preclinical AD, pointing to its potential utility as an early marker of dementia.
Joseph R. Scarpa +5 more
doaj +1 more source
Antagonistic Regulation of Circadian Output and Synaptic Development by JETLAG and the DYSCHRONIC-SLOWPOKE Complex [PDF]
, 2020 Circadian output genes act downstream of the clock to promote rhythmic changes in behavior and physiology, yet their molecular and cellular functions are not well understood. Here we characterize an interaction between regulators of circadian entrainment,
Akpoghiran, Oghenerukevwe +3 more
core +1 more source
A miR-219-5p-bmal1b negative feedback loop contributes to circadian regulation in zebrafish
Communications BiologyMicroRNAs post-transcriptionally regulate gene expression and contribute to numerous life processes, including circadian rhythms. However, whether miRNAs contribute to zebrafish circadian regulation has not yet been investigated.
Lianxin Wu +3 more
doaj +1 more source