Results 21 to 30 of about 179,291 (266)
Psychological Screening for Exceptional Environments: Laboratory Circadian Rhythm and Sleep Research
Clocks & Sleep, 2020 Selecting participants who constitute a representative sample while protecting them from potential adverse outcomes is a concern for clinical researchers.
Stephen A. Amira +4 more
doaj +1 more source
The retinal ipRGC-preoptic circuit mediates the acute effect of light on sleep
Nature Communications, 2021 The preoptic area (POA) is critical for sleep regulation but its role in acute, non-circadian, light effects on sleep are unclear. The authors show that intrinsically photosensitive retinal ganglion cells provide substantial input into the POA and ...
Ze Zhang +3 more
doaj +1 more source
Accuracy of Three Commercial Wearable Devices for Sleep Tracking in Healthy Adults
SensorsSleep tracking by consumers is becoming increasingly prevalent; yet, few studies have evaluated the accuracy of such devices. We sought to evaluate the accuracy of three devices (Oura Ring Gen3, Fitbit Sense 2, and Apple Watch Series 8) compared to the ...
Rebecca Robbins +10 more
doaj +1 more source
NREM delta power and AD-relevant tauopathy are associated with shared cortical gene networks
Scientific Reports, 2021 Reduced NREM sleep in humans is associated with AD neuropathology. Recent work has demonstrated a reduction in NREM sleep in preclinical AD, pointing to its potential utility as an early marker of dementia.
Joseph R. Scarpa +5 more
doaj +1 more source
A miR-219-5p-bmal1b negative feedback loop contributes to circadian regulation in zebrafish
Communications BiologyMicroRNAs post-transcriptionally regulate gene expression and contribute to numerous life processes, including circadian rhythms. However, whether miRNAs contribute to zebrafish circadian regulation has not yet been investigated.
Lianxin Wu +3 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
CCorGsDB: a database for clock correlated genes in the mouse and human central nervous systems
npj Biological Timing and SleepWe developed CCorGsDB, a web-based resource integrating mouse and human CNS co-expression networks filtered by circadian biomarkers. We validated the networks using time-series data from sixteen mouse regions and identified a conserved set of 251 ...
José Luiz Araújo Santos +4 more
doaj +1 more source
Wellcome Open Research, 2017 Background: Disruption of rhythms in activity and rest occur in many diseases, and provide an important indicator of healthy physiology and behaviour. However, outside the field of sleep and circadian rhythm research, these rhythmic processes are rarely ...
Laurence A. Brown +3 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source