Results 111 to 120 of about 347,727 (386)
Ror homolog nhr-23 is essential for both developmental clock and circadian clock in C. elegans
Communications BiologyAnimals have internal clocks that generate biological rhythms. In mammals, clock genes such as Period form the circadian clock to generate approximately 24-h biological rhythms. In C. elegans, the clock gene homologs constitute the “developmental clock”,
Shingo Hiroki, Hikari Yoshitane
doaj +1 more source
The circadian clock coordinates ribosome biogenesis.
PLoS Biology, 2013 Biological rhythms play a fundamental role in the physiology and behavior of most living organisms. Rhythmic circadian expression of clock-controlled genes is orchestrated by a molecular clock that relies on interconnected negative feedback loops of ...
Céline Jouffe +6 more
doaj +1 more source
Discrete gene replication events drive coupling between the cell cycle and circadian clocks [PDF]
, 2015 Many organisms possess both a cell cycle to control DNA replication and a circadian clock to anticipate changes between day and night. In some cases, these two rhythmic systems are known to be coupled by specific, cross-regulatory interactions. Here, we use mathematical modeling to show that, additionally, the cell cycle generically influences ...
arxiv +1 more source
Robust circadian clocks from coupled protein modification and transcription-translation cycles [PDF]
P Natl Acad Sci Usa (2010) vol. 107 (52) pp. 22540-5, 2010 The cyanobacterium Synechococcus elongatus uses both a protein phosphorylation cycle and a transcription-translation cycle to generate circadian rhythms that are highly robust against biochemical noise. We use stochastic simulations to analyze how these cycles interact to generate stable rhythms in growing, dividing cells.
arxiv +1 more source
Advanced Science, EarlyView.Kdm4a downregulation restrains excessive cardiac interstitial fibrosis and remodeling by depressing the premature senescence of fibroblasts in the advanced stage after MI but does not affect early ventricular rupture. It verified that Kdm4a downregulation promotes autophagy in premature senescent fibroblasts by increasing the H3K9m3 modification of the
Ming Jin +15 more
wiley +1 more source
NF-κB modifies the mammalian circadian clock through interaction with the core clock protein BMAL1.
PLoS Genetics, 2021 In mammals, the circadian clock coordinates cell physiological processes including inflammation. Recent studies suggested a crosstalk between these two pathways. However, the mechanism of how inflammation affects the clock is not well understood.
Yang Shen +11 more
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How Coupling Determines the Entrainment of Circadian Clocks [PDF]
, 2011 Autonomous circadian clocks drive daily rhythms in physiology and behaviour. A network of coupled neurons, the suprachiasmatic nucleus (SCN), serves as a robust self-sustained circadian pacemaker. Synchronization of this timer to the environmental light-dark cycle is crucial for an organism's fitness.
arxiv +1 more source
Modeling Transient Changes in Circadian Rhythms [PDF]
arXiv, 2023 The circadian clock can adapt itself to external cues, but the molecular mechanisms and regulatory networks governing circadian oscillations' transient adjustments are still largely unknown. Here we consider the specific case of circadian oscillations transiently responding to a temperature change.
arxiv
Advanced Science, EarlyView.New research reveals that oxytocin signaling during the early postnatal period is critical for regulating brain development and social behavior. Selectively suppressing oxytocin neurons by chemogenetic method shows that early—but not late—disruption leads to autism‐like behaviors.
Zi‐Hui Wang +10 more
wiley +1 more source
The Molecular Circadian Clock and Alcohol-Induced Liver Injury
Biomolecules, 2015 Emerging evidence from both experimental animal studies and clinical human investigations demonstrates strong connections among circadian processes, alcohol use, and alcohol-induced tissue injury.
Uduak S. Udoh +3 more
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