Results 111 to 120 of about 402,265 (407)

Circadian Rhythms in the CNS and Peripheral Clock Disorders: The Circadian Clock and Hyperlipidemia

Journal of Pharmacological Sciences, 2007
A circadian clock controls various physiological and behavioral rhythms. In mammals, a master circadian clock exists in the suprachiasmatic nucleus of the hypothalamus, and slave oscillators can be found in most tissues.
Takashi Kudo, Kazumasa Horikawa, Shigenobu Shibata   +2 more
doaj  

Ror homolog nhr-23 is essential for both developmental clock and circadian clock in C. elegans

Communications Biology
Animals have internal clocks that generate biological rhythms. In mammals, clock genes such as Period form the circadian clock to generate approximately 24-h biological rhythms. In C. elegans, the clock gene homologs constitute the “developmental clock”,
Shingo Hiroki, Hikari Yoshitane
doaj   +1 more source

Evolutionary relationships among barley and Arabidopsis core circadian clock and clock-associated genes [PDF]

, 2015
The circadian clock regulates a multitude of plant developmental and metabolic processes. In crop species, it contributes significantly to plant performance and productivity and to the adaptation and geographical range over which crops can be grown.
A Helfer, A Para, A Pokhilko, A Pokhilko, A Turner, A Zimmer, AB James, AB James, AH Paterson, AN Dodd, B Yu, BS Shin, BY Chow, C Campoli, C Campoli, C Campoli, C Li, C Lillo, C Troein, CR McClung, Cristiane P. G. Calixto, CT Hotta, D Alabadí, DA Matos, DB Fowler, DH Nagel, E Kolmos, E Ogiso, E Tauber, F Prosdocimi, F Valverde, F Yon, H Okamura, HR Song, J Cockram, J Felsenstein, JA Higgins, JC Locke, JC Schnable, JM Gendron, John W. S. Brown, JW Yu, K Holm, K Onai, K Tamura, K Tamura, KF Mayer, L Vallelian-Bindschedler, M Endo, M Gallego, M Iwamoto, M Klintenäs, M Martínez, M Murakami, M Serikawa, MA Larkin, MF Covington, MJ Haydon, MJ Moore, MN Zeilinger, N Nakamichi, N Nakamichi, N Saitou, N Suetsugu, N Takata, N Takata, P Lou, PA Pin, R Hayama, R Nitcher, R Poiré, RM Green, Robbie Waugh, RP Dunford, S Faure, S Faure, S Griffiths, S Nagasaka, S Stracke, S Zakhrabekova, SB Satbhai, SE Sanchez, SF Altschul, SF Boxall, SL Harmer, SL Harmer, SM Chaw, T Matsumoto, TA Miller, TP Michael, W Huang, W-Y Kim, X Wang, Y Kobayashi, Z Chen   +94 more
core   +2 more sources

The Circadian Clock, Reward, and Memory [PDF]

Frontiers in Molecular Neuroscience, 2011
During our daily activities, we experience variations in our cognitive performance, which is often accompanied by cravings for small rewards, such as consuming coffee or chocolate. This indicates that the time of day, cognitive performance, and reward may be related to one another.
openaire   +5 more sources

The Circadian Clocks of Mice and Men [PDF]

Neuron, 2001
Major strides have been made toward understanding the molecular mechanism of rodent clocks. But how far do those steps carry us toward understanding circadian clock function in humans? Practical advances in human genetics, not the least of which is the availability of a virtually complete genome sequence, now allow animal research to be complemented by
Chang, Dennis C., Reppert, Steven M.
openaire   +4 more sources

Artesunate Nanoplatform Targets the Serine–MAPK Axis in Cancer‐Associated Fibroblasts to Reverse Photothermal Resistance in Triple‐Negative Breast Cancer

Advanced Materials, EarlyView.
The artesunate nanoplatform selectively targets ECM CAF, functioning as a GTPase inhibitor through disruption of intracellular serine homeostasis. This metabolic intervention effectively suppresses MAPK cascade activity, which consequently inhibits PTT‐induced CAF to ECM CAF differentiation.
Dongdong Zheng, Jiaqi Yan, Xuejiao Liu, Zhiming Zhang, Anqi Jin, Yue Zhao, Lu Bai, Mengyao Quan, Xiuzhu Qi, Bin Fu, Zhigang Wu, Jin Zhou, Han Han, Ziqi Wang, Shiyu Wang, Chaoqiang Deng, Weijian Sun, Cai Chang, Shichong Zhou, Hongbo Zhang   +19 more
wiley   +1 more source

The circadian clock coordinates ribosome biogenesis.

PLoS Biology, 2013
Biological rhythms play a fundamental role in the physiology and behavior of most living organisms. Rhythmic circadian expression of clock-controlled genes is orchestrated by a molecular clock that relies on interconnected negative feedback loops of ...
Céline Jouffe, Gaspard Cretenet, Laura Symul, Eva Martin, Florian Atger, Felix Naef, Frédéric Gachon   +6 more
doaj   +1 more source

NF-κB modifies the mammalian circadian clock through interaction with the core clock protein BMAL1.

PLoS Genetics, 2021
In mammals, the circadian clock coordinates cell physiological processes including inflammation. Recent studies suggested a crosstalk between these two pathways. However, the mechanism of how inflammation affects the clock is not well understood.
Yang Shen, Mehari Endale, Wei Wang, Andrew R Morris, Lauren J Francey, Rachel L Harold, David W Hammers, Zhiguang Huo, Carrie L Partch, John B Hogenesch, Zhao-Hui Wu, Andrew C Liu   +11 more
doaj   +1 more source

Sexual Differentiation of Circadian Clock Function in the Adrenal Gland [PDF]

, 2016
Sex differences in glucocorticoid production are associated with increased responsiveness of the adrenal gland in females. However, the adrenal-intrinsic mechanisms that establish sexual dimorphic function remain ill defined. Glucocorticoid production is
Evans, Jennifer A., Gasser, Paul J, Klement, Claire, Kloehn, Ian, Officer, Laurel, Pillai, Savin B.   +5 more
core   +2 more sources

Dual‐Selective Terahertz‐Nanodisc Metasurfaces for Exploring Neurotransmitter Dynamics beyond Spectral Limitations

Advanced Materials, EarlyView.
Observation and detection of neurotransmitter dynamics in aqueous system has been hurdle for analytical fields due to its weak and reversible nature. A terahertz‐nanodisc metasurface which implements comprehensive detection over conformational change and selective sensing is introduced. Utilizing the THz regime photonics and biomimetic environment with
Taeyeon Kim, Yeon Kyung Lee, Yeeun Roh, Jaehun Park, Yong‐Sang Ryu, Hyun Seok Song, Minah Seo   +6 more
wiley   +1 more source