Results 231 to 240 of about 109,508 (306)

Analysis of C4 Concentrations to Predict Impact of Patient‐Reported Diarrhea Associated With the Ileal Bile Acid Transporter Inhibitor Linerixibat

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 596-605, March 2025.
ABSTRACT Linerixibat, an ileal bile acid transporter (IBAT) inhibitor, is being evaluated for the treatment of pruritus in primary biliary cholangitis (PBC). Diarrhea is commonly reported with this drug class as IBAT inhibition redirects bile acids (BA) to the colon.
Fernando Carreño, Rashmi Mehta, Andrea Ribeiro de Souza, Jon Collins, Brandon Swift   +4 more
wiley   +1 more source

Role of circadian clock in female embryo implantation. [PDF]

Front Cell Dev Biol
Zhou Y, He X, Chen Z, Gou Y, Zhou K, Huang J, Chen M, Hong J, Gao L.   +8 more
europepmc   +1 more source

Exploring Linalool‐Based Phytotherapy for Excitatory/Inhibitory Imbalance in Alzheimer's Disease: A Review of Lavender and Cannabis Therapeutic Effects on Sleep, Seizures, and Cognition

Phytotherapy Research, EarlyView.
Schematic overview of the proposed neuromodulatory actions of linalool in Alzheimer's disease. Through multi‐target effects on oxidative stress, amyloid aggregation, GABAergic and glutamatergic signaling, linalool may restore excitatory/inhibitory balance.
Ilaria Piccialli, Giovanni Roviello, Giorgia Magliocca, Emilia Esposito, Anna Pannaccione   +4 more
wiley   +1 more source

The circadian clock component PER2 deficiency aggravates airway epithelial remodeling through Wnt/β-catenin signaling pathway. [PDF]

Respir Res
Zhang S, Lin J.
europepmc   +1 more source

Cameras do not always take a full picture: wolf activity patterns revealed by accelerometers versus road‐positioned camera traps

Remote Sensing in Ecology and Conservation, EarlyView.
Camera traps have become an increasingly popular non‐invasive alternative to animal‐attached devices for studying wildlife behaviour. This study compared wolf (Canis lupus) activity patterns derived from collar accelerometers and road‐positioned camera traps and revealed strong overall agreement but also important seasonal and diel mismatches between ...
Katarzyna Bojarska, Michał Żmihorski, Morteza Naderi, J. David Blount, Mark Chynoweth, Emrah Coban, Çağan H. Şekercioğlu, Josip Kusak   +7 more
wiley   +1 more source

Conserved eukaryotic factors XCT and COP1 work together to control circadian clock function and reproductive timing in plants. [PDF]

NPJ Biol Timing Sleep
Kumimoto RW, Marshall CM, Zhang H, Harmer SL.   +3 more
europepmc   +1 more source

Non‐Invasive Brain Stimulation in Chronic Pain: Current Evidence, Network Perspectives and Paths to Personalization

Sensory Neuroscience, EarlyView.
Chronic pain reflects maladaptive network interactions across sensory, salience/affective, and descending modulatory pathways. We review evidence for non‐invasive brain stimulation—rTMS, tES, and low‐intensity focused ultrasound—highlighting modest, variable, and often short‐lived analgesic effects under conventional protocols.
Fabian Broecker, Sven Vanneste
wiley   +1 more source

The circadian clock, metabolism, and inflammation-the holy trinity of inflammatory bowel diseases. [PDF]

Clin Sci (Lond)
Froy O, Weintraub Y.
europepmc   +1 more source

Association of insomnia, insulin resistance traits, and cardiovascular disease risk: A two‐step Mendelian randomization study

Sleep Research, EarlyView.
The causal roles of metabolic traits in mediating the effects of insomnia on CVDs. CAD, coronary artery disease; HbA1c, hemoglobin A1c; HDL‐C, high‐density lipoprotein cholesterol; IR, insulin resistance; MI, myocardial infarction; TG, triglyceride; T2DM, type 2 diabetes.
Binhe Yu, Yanmin Xu, Xiaoyu Wang, Shuo Ye, Ruixiang Cui, Yujing Sun, Meng Li, Yan Li, Wenhui Yuan, Sheng Guo, Zhigang Chen, Xiaohong Kang, Sizhi Ai   +12 more
wiley   +1 more source

The ontogeny of circadian clock gene expression during mouse fetal development. [PDF]

Biochem Biophys Rep
Stanton DL, Zhu L, Hansen PJ.
europepmc   +1 more source