Results 241 to 250 of about 301,259 (301)

Disrupted joint clock is associated with rhythmic expression of bone destruction factors in collagen‐induced arthritis

Rheumatology &Autoimmunity, EarlyView.
Schematic Summary of Circadian Dysregulation in Arthritic Joints. This graphical abstract illustrates the key circadian disruptions observed in the collagen‑induced arthritis (CIA) model. The diagram depicts three main findings: (1) Nocturnal elevations in pro‑inflammatory cytokines (TNF‑α, IL‑6, IL‑17, IL‑1β, MIF) and bone‑destructive factors (DKK‑1 ...
Xiaogang Zhang, Mingming Zhang, Zhiqiang Wang, Jie Bai, Xing Feng, Yajing Wang, Zhenbin Li, Dongbao Zhao   +7 more
wiley   +1 more source

A temporal dialogue between the circadian clock and chronic inflammatory diseases. [PDF]

Dis Model Mech
Chen S, Ray D.
europepmc   +1 more source

Repurposing Bird‐Based Acoustic Models for Amphibian Surveys: Strengths and Limitations in Real‐World Deployments

Remote Sensing in Ecology and Conservation, EarlyView.
In this study, we developed AnuraSearch, an open‐source classifier for 11 Ukrainian amphibian species, by repurposing the avian BirdNET algorithm via transfer learning to process over 18,000 h of autonomous acoustic recordings. Although the model demonstrated high precision and successfully reconstructed detailed seasonal and diel vocal activity ...
Vasylyna Strus, Yurii Strus, Nazar Smirnov, Anna Fedorova, Nataliia Suriadna, Mykola Drohvalenko   +5 more
wiley   +1 more source

The circadian clock component NPAS2 is modulated by AMPK and regulates substrate utilization and mitochondrial function in human skeletal muscle cells. [PDF]

Mol Metab
Rizo-Roca D, Pendergrast LA, Kamble P, Guimarães DSPSF, Dollet L, Björnholm M, Zierath JR.   +6 more
europepmc   +1 more source

Potential value of slow‐wave sleep in management of chronic insomnia disorder

Sleep Research, EarlyView.
Abstract Chronic insomnia disorder (CID), acknowledged as the most common sleep disorder, has traditionally been diagnosed and managed with a focus on reducing sleep onset latency and extending total sleep duration. However, the critical importance of slow‐wave sleep (SWS), a key indicator of objective sleep quality, has been largely overlooked in ...
Liping Zhang, Qi Wu, Mengmeng Fan, Xianchao Zhao, Changjun Su   +4 more
wiley   +1 more source

The Evolutionary Flexibility of the Drosophila Circadian Clock: Network Constraints or Adaptive Freedom? [PDF]

Genome Biol Evol
Creasey LD, Petrov PB, Tauber E.
europepmc   +1 more source

Electron‐Transfer Engineered Biointerface With Detonation Nanodiamonds for Next‐Generation Cortisol Electrochemical Immunoassay

Small, EarlyView.
Screen‐printed carbon electrode biointerface featuring detonation nanodiamond layer with the sp2/sp3 carbon interface that optimizes charge transfer and enables covalent immobilization of cortisol antibodies. The designed electrochemical sensor provides high selectivity, stability and rapid cortisol detection also from saliva samples.
Chakavak Esmaeili, Jaroslav Kuliček, Markéta Šlapal Bařinková, Bohuslav Rezek   +3 more
wiley   +1 more source

The Cardiac Circadian Clock Regulates Rhythms in Peripheral Tissues via Fibulin 5. [PDF]

Compr Physiol
Bettadapura SS, Tangeman DC, Satyanarayana SB, Ruhmann MM, Bonds WJ, Edwards JH, Gupta P, Yusifov A, Todd WD, Bruns DR.   +9 more
europepmc   +1 more source

Humidity Ramp Protocols Systematically Underestimate Human Heat Tolerance Limits

Safety Science and Technology, EarlyView.
Short dwell times in humidity‐ramp protocols (Δt/τ≪1 ${\Delta }t/\tau \mathit{\ll }1$) prevent human core temperature from reaching equilibrium, causing premature inflection points and systematic underestimation of critical environmental limits by ∼3°C–4°C.
Fèlix Faming Wang, Yi Xu, Haojian Wang, Min Cui, Xue Hou, Boan Wei, Xiong Shen   +6 more
wiley   +1 more source

Influence of Age and Exposure Pathway on Copper and Cadmium Mixture Toxicity: A Study on Daphnia magna

Environmental Toxicology, EarlyView.
ABSTRACT Metal contamination in aquatic ecosystems poses substantial risks to freshwater organisms, with mixture effects often deviating from predictions based on single‐metal toxicity. Understanding how age‐specific sensitivities and multiple exposure pathways influence mixture effects is critical for accurate risk assessment.
Sanah Majid, Karen Smeets, Mubiana K. Valentine, Ronny Blust   +3 more
wiley   +1 more source