Results 241 to 250 of about 369,771 (309)

Resveratrol and dexamethasone have cell-specific effects on the circadian clock but not on the rhythm of mitochondrial function in the fetal heart. [PDF]

J Physiol Biochem
Semenovykh D, Semenovykh K, Sládek M, Sumová A.   +3 more
europepmc   +1 more source

Synergistic transition from type‐I‐like to type‐II‐like symptomology in a pyrethroid mixture and its impact on knockdown–mortality relationships in Musca domestica L

Pest Management Science, EarlyView.
In the present study, relationship between knockdown and mortality of insecticides was examined against the adult female housefly, Musca domestica. Type‐I pyrethroid insecticides showed a weak linkage, as early knocked down flies did not always result in mortality, while type‐II pyrethroids and organophosphates exhibited strong correlation between the ...
Junho Yoon, Jun‐Hyung Tak
wiley   +1 more source

Research progress on the mutual regulatory mechanism of circadian clock genes and autophagy. [PDF]

Front Cell Dev Biol
Ma Y, Yu R, Zheng X, Rao J, Shi G, Ding Y.   +5 more
europepmc   +1 more source

Effects of timed LED regimes on tomato plant traits, performance of two‐spotted spider mites, and predatory mites (Phytoseiulus persimilis)

Pest Management Science, Volume 81, Issue 4, Page 2300-2311, April 2025.
Light‐emitting diode (LED)‐based treatments for enhancing crop production and pest management have primarily focused on continuous treatments. This study, using Tetranychus urticae and Phytoseiulus persimilis, demonstrates that the timing of LED supplementation is crucial for designing integrated pest management strategies that improve both plant ...
Patrice Savi, Samantha Hall, Maria Hernandez, Anil Mantri, Daniel Kliebenstein, Christian Nansen   +5 more
wiley   +1 more source

Dissecting usuranme biquitin-mediated circadian clock regulation in Arabidopsis via high-throughput yeast screens. [PDF]

J Exp Bot
Tu YT, Chen CA, Gendron JM, Lee CM.
europepmc   +1 more source

Physiologically based pharmacokinetic modeling and simulation of topiramate in populations with renal and hepatic impairment and considerations for drug–drug interactions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 510-522, March 2025.
Abstract Topiramate (TPM) is a broad‐spectrum antiepileptic drug (AED) commonly prescribed for approved and off‐label uses. Routine monitoring is suggested for clinical usage of TPM in special population due to its broad side effect profile. Therefore, it is crucial to further explore its pharmacokinetic characteristics.
Shuqing Chen, Chaozhuang Shen, Yuchen Tian, Yuhe Peng, Jing Hu, Haitang Xie, Ping Yin   +6 more
wiley   +1 more source

Perturbation of the circadian clock in chronic diseases involving organ fibrosis. [PDF]

J Clin Invest
Mukherji A, Tharaux PL, Ray DW, Baumert TF.   +3 more
europepmc   +1 more source

Analysis of C4 Concentrations to Predict Impact of Patient‐Reported Diarrhea Associated With the Ileal Bile Acid Transporter Inhibitor Linerixibat

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 596-605, March 2025.
ABSTRACT Linerixibat, an ileal bile acid transporter (IBAT) inhibitor, is being evaluated for the treatment of pruritus in primary biliary cholangitis (PBC). Diarrhea is commonly reported with this drug class as IBAT inhibition redirects bile acids (BA) to the colon.
Fernando Carreño, Rashmi Mehta, Andrea Ribeiro de Souza, Jon Collins, Brandon Swift   +4 more
wiley   +1 more source

Paf1C regulates the Neurospora circadian clock by promoting the transcription elongation of frequency. [PDF]

PLoS Genet
Zhou M, Zhao Y, He Y, Duan Z, Liu X, He Q.   +5 more
europepmc   +1 more source

Disrupted joint clock is associated with rhythmic expression of bone destruction factors in collagen‐induced arthritis

Rheumatology &Autoimmunity, EarlyView.
Schematic Summary of Circadian Dysregulation in Arthritic Joints. This graphical abstract illustrates the key circadian disruptions observed in the collagen‑induced arthritis (CIA) model. The diagram depicts three main findings: (1) Nocturnal elevations in pro‑inflammatory cytokines (TNF‑α, IL‑6, IL‑17, IL‑1β, MIF) and bone‑destructive factors (DKK‑1 ...
Xiaogang Zhang, Mingming Zhang, Zhiqiang Wang, Jie Bai, Xing Feng, Yajing Wang, Zhenbin Li, Dongbao Zhao   +7 more
wiley   +1 more source