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Transcriptional architecture of the mammalian circadian clock
Nature Reviews Genetics, 2016 Circadian clocks are endogenous oscillators that control 24-hour physiological and behavioural processes in organisms. These cell-autonomous clocks are composed of a transcription–translation-based autoregulatory feedback loop.
Joseph S Takahashi, Takahashi Joseph S
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Interplay between Circadian Clock and Cancer: New Frontiers for Cancer Treatment
Trends in Cancer, 2019 Circadian clocks are evolutionary molecular machinery that dictate temporal regulation of physiology to maintain homeostasis. Disruption of circadian rhythm plays a key role in tumorigenesis and facilitates the establishment of cancer hallmarks ...
Michael Tun Yin Lam +1 more
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Defining the Independence of the Liver Circadian Clock
Cell, 2019 SUMMARY Mammals rely on a network of circadian clocks to control daily systemic metabolism and physiology. The central pacemaker in the suprachiasmatic nucleus (SCN) is considered hierarchically dominant over peripheral clocks, whose degree of ...
Kevin B Koronowski +2 more
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Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR
Cell, 2018 Summary: Recent reports ind icate hypoxia influences the circadian clock through the transcriptional activities of hypoxia inducible factors (HIFs) at clock genes.
Chirag H Patel +2 more
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Mutation of the Human Circadian Clock Gene CRY1 in Familial Delayed Sleep Phase Disorder
Cell, 2017 SUMMARY Patterns of daily human activity are controlled by an intrinsic circadian clock that promotes ~24 hour rhythms in many behavioral and physiological processes.
Alina Patke +2 more
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The Circadian Clock and Obesity
2022The modern way of life has dramatically affected our biological rhythms. Circadian rhythms, which are generated by an endogenous circadian clock, are observed in a large number of physiological functions including metabolism. Proper peripheral clock synchronization by different signals including appropriate feeding/fasting cycles is essential to ...
Sebti, Yasmine +4 more
openaire +2 more sources