Results 241 to 250 of about 109,508 (306)

Bile acid metabolism and sleep: Mechanistic interplay and clinical implications of the gut–liver–brain axis

Sleep Research, EarlyView.
Abstract The bidirectional interplay between sleep and metabolic homeostasis is fundamental to physiological health. While the roles of glucose and lipid metabolism in sleep regulation have been extensively characterized, bile acids (BAs), which are traditionally viewed as digestive surfactants, are emerging as critical metabolic messengers with ...
Yu Jiang, Shuangyan Li, Dhirendra Paudel, Miaoqin Tan, Bin Zhang   +4 more
wiley   +1 more source

Circadian Clock Dysfunction Exacerbate Autistic-Like Behaviour and Wnt/β-Catenin Signalling Dysregulation in ASD Mice and Treatment of Melatonin. [PDF]

J Cell Mol Med
Zhang Y, Chen Y, Li W, Tang L, Wang G, Li J, Feng X.   +6 more
europepmc   +1 more source

Nanomaterials' Multigenerational Effects by Single and Joint Exposure in Non‐mammalian Models

Environmental Toxicology, EarlyView.
ABSTRACT Nanotoxicology has mainly focused on single‐generation studies, leaving multigenerational toxicity underexplored. Having animal welfare recently gained importance, we aimed to provide the state‐of‐the‐art of knowledge about multigenerational effects in non‐mammalian models in the case of nanomaterials (NM) single and joint exposure to other ...
Andy Joel Taipe Huisa, Analía Ale, Azael Francisco Silva Neto, Lorena De Mendonça Lucena, Marcelo Estrella Josende, Milena Ferreira de Lima, Rhayanny Kethylly Pereira Santos, Martín Federico Desimone, Priscila Gubert, José María Monserrat   +9 more
wiley   +1 more source

Reprogramming feedback strength in gibberellin biosynthesis highlights conditional regulation by the circadian clock and carbon dioxide. [PDF]

PLoS One
Leydon AR, Flores L, Khakhar A, Nemhauser JL.   +3 more
europepmc   +1 more source

Diving Deeper Into Mechanisms of Acrylamide‐Induced Toxicity: RNA Sequencing Reveals Transcriptomic Alteration and Retrotransposon Expression in Drosophila melanogaster

Environmental Toxicology, EarlyView.
ABSTRACT Given the inevitability of human and animal exposure to acrylamide, there is increasing concern regarding its potential health risks. While a number of molecular mechanisms have been proposed, the complexity of acrylamide toxicological pathways and interactions remains incompletely characterized.
Oluwabukola Mary Farodoye, Titilayomi Ayomide Otenaike, Daniela Moreira Mombach, Monica Medeiros Silva, Amos Olalekan Abolaji, Elgion Lucio Da Silva Loreto   +5 more
wiley   +1 more source

Research progress on the role and mechanism of circadian clock gene <i>PER1</i> in the occurrence and development of multiple diseases. [PDF]

Front Immunol
Zhao Y, Li Y, Lu T, Huang X, Chen K, Tan L, Gao L.   +6 more
europepmc   +1 more source

Analysis of serum biomarkers associated with pain in Spanish greyhounds undergoing ovariohysterectomy

Veterinary Record, EarlyView.
Background This study measured serum biomarkers at baseline and during an ovariohysterectomy in healthy female Spanish greyhounds, aiming to enhance the objectivity of current methods for assessing acute postoperative pain in dogs. Methods Blood samples from 20 Spanish greyhounds were collected before drug administration (T0‐baseline).
Rocio Navarrete‐Calvo, Jose Andrés Fernández‐Sarmiento, Juan Morgaz, Alba Galán‐Rodríguez, Rafael J. Gómez‐Villamandos, Pablo Parra, María del Mar Granados, Setefilla Quirós‐Carmona, Irene M. Rodríguez‐Gómez   +8 more
wiley   +1 more source

Synaptic targets of circadian clock neurons influence core clock parameters. [PDF]

Sci Adv
Scholz-Carlson E, Iyer AR, Nern A, Ewer J, Fernandez MP.   +4 more
europepmc   +1 more source

Inflammatory Shift in Chronic Rhinosinusitis Amidst Guangzhou's Urbanization (2000–2018)

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) exhibits temporal and geographic diversity in pathological endotypes with progressive eosinophilic infiltration, while the underlying causes remain unclear. Current pathological endotypes determination relies on mean cell count per high‐power field, requiring accuracy optimization.
Ning Kang, Man‐Hou Chao, Xin Luo, Feng‐Wen Shan, Zi‐Xuan Hua, Ze‐Zhi Guo, Hua‐Mei Yan, He Zhang, Tong Wu, Min Zhou, Rui Zheng, Shuo Wu, Xue‐Kun Huang, Zhao‐Hui Shi, Ya‐Na Zhang, Ji Yang, Qin‐Tai Yang   +16 more
wiley   +1 more source