Results 111 to 120 of about 67,567 (286)

Circadian Clock Genes in the Metabolism of Non-alcoholic Fatty Liver Disease

Frontiers in Physiology, 2019
Non-alcoholic fatty liver disease (NAFLD) is a common disease, which is characterized by the accumulation of triglycerides in the hepatocytes without excess alcohol intake.
Dongmei Shi, Jie Chen, Jie Chen, Jiaofeng Wang, Jiaofeng Wang, Jianfeng Yao, Yiqin Huang, Gansheng Zhang, Zhijun Bao, Zhijun Bao   +9 more
doaj   +1 more source

Mutation of Arabidopsis SPLICEOSOMAL TIMEKEEPER LOCUS1 Causes Circadian Clock Defects [PDF]

, 2012
The circadian clock plays a crucial role in coordinating plant metabolic and physiological functions with predictable environmental variables, such as dusk and dawn, while also modulating responses to biotic and abiotic challenges.
Brown, John WS, Harmer, Stacey L, Jones, Matthew A, McNicol, Jim, Simpson, Craig G, Williams, Brian A   +5 more
core   +1 more source

Endometrial Assembloid Model Reveals Endometrial Gland Development Regulation by Estradiol‐Driven WNT7B Suppression

Advanced Science, EarlyView.
This study developed a 3D endometrial assembloid model to study how uterine glands form and develop. They discovered key interactions between different cell types and identified WNT7B as a regulator controlled by estradiol‐mediated TGFβ1‐VDR interaction.
Xintong Li, Yanjie Guo, Jianlin Li, Yimeng Li, Leqian Lin, Hoi Kit Matthew Leung, Qingqing Zhang, Kai‐Fai Lee, Ka‐Wang Cheung, Ernest H. Y. Ng, William S. B. Yeung, Philip C. N. Chiu, Cheuk‐Lun Lee   +12 more
wiley   +1 more source

Circadian clock genes contribute to the regulation of hair follicle cycling.

PLoS Genetics, 2009
Hair follicles undergo recurrent cycling of controlled growth (anagen), regression (catagen), and relative quiescence (telogen) with a defined periodicity.
Kevin K Lin, Kevin K Lin, Vivek Kumar, Mikhail Geyfman, Darya Chudova, Alexander T Ihler, Padhraic Smyth, Ralf Paus, Joseph S Takahashi, Bogi Andersen   +9 more
doaj   +1 more source

Is the aging human ovary still ticking?: Expression of clock-genes in luteinized granulosa cells of young and older women

Journal of Ovarian Research, 2018
Background It has been shown – mostly in animal models - that circadian clock genes are expressed in granulosa cells and in corpora luteum and might be essential for the ovulatory process and steroidogenesis.
Amnon Brzezinski, A. Saada, H. Miller, NA Brzezinski-Sinai, A. Ben-Meir   +4 more
doaj   +1 more source

Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions [PDF]

, 2015
A workshop was held at the National Institute for Diabetes and Digestive and Kidney Diseases with a focus on the impact of sleep and circadian disruption on energy balance and diabetes.
Arble, Deanna M, Bass, Joseph, Behn, Cecilia Diniz, Butler, Matthew P, Challet, Etienne, Czeisler, Charles, Depner, Christopher M, Elmquist, Joel, Franken, Paul, Grandner, Michael A, Hanlon, Erin C, Joyner, Michael J, Karatsoreos, Ilia, Keene, Alex C, Kern, Philip A, Klein, Samuel, Morris, Christopher J, Pack, Allan I, Panda, Satchidananda, Ptacek, Louis J, Punjabi, Naresh M, Sassone-Corsi, Paolo, Saxena, Richa, Scheer, Frank A, Scheer, Frank A, Seaquest, Elizabeth R, Thimgan, Matthew S, Van Cauter, Eve, Wright, Kenneth P   +28 more
core   +4 more sources

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

Expression conservation within the circadian clock of a monocot: natural variation at barley Ppd-H1 affects circadian expression of flowering time genes, but not clock orthologs

BMC Plant Biology, 2012
Background The circadian clock is an endogenous mechanism that coordinates biological processes with daily changes in the environment. In plants, circadian rhythms contribute to both agricultural productivity and evolutionary fitness.
Campoli Chiara, Shtaya Munqez, Davis Seth J, von Korff Maria   +3 more
doaj   +1 more source

Ontogeny of the circadian clock in Sarcophaga crassipalpis [PDF]

, 2016
The timing of circadian rhythms is controlled by the rhythmic expression of clock genes in pacemaker neurons within the brain. Circadian gene expression and behavior can entrain to thermoperiod and photoperiod.
Short, Clancy
core  

Analysis of DNA-Damage Response to ionizing radiation in serum-shock synchronized human fibroblasts. [PDF]

, 2017
Many aspects of cellular physiology, including cellular response to genotoxic stress, are related to the circadian rhythmicity induced by the molecular clock.
Barbieri, Vito, Bee, Leonardo, Corra', Samantha, Mognato, Maddalena, Salvadori, Riccardo   +4 more
core   +1 more source