Results 51 to 60 of about 67,567 (286)

Circadian Clock Genes in Diabetic Kidney Disease (DKD) [PDF]

Current Diabetes Reports, 2019
The purpose of this review is to provide a brief summary about the current state of knowledge regarding the circadian rhythm in the regulation of normal renal function.There is a lack of information regarding how the circadian clock mechanisms may contribute to the development of diabetic kidney disease.
Olanrewaju A, Olaoye, Sarah H, Masten, Rajesh, Mohandas, Michelle L, Gumz   +3 more
openaire   +2 more sources

Dawn- and dusk-phased circadian transcription rhythms coordinate anabolic and catabolic functions in Neurospora [PDF]

, 2015
Background: Circadian clocks control rhythmic expression of a large number of genes in coordination with the 24 hour day-night cycle. The mechanisms generating circadian rhythms, their amplitude and circadian phase are dependent on a transcriptional ...
Brunner, Michael, Cesbron, François, Ha, Nati, Sancar, Cigdem, Sancar, Gencer   +4 more
core   +1 more source

Alterations of clock gene RNA expression in brain Regions of a triple transgenic model of Alzheimer's Disease [PDF]

, 2017
A disruption to circadian rhythmicity and the sleep/wake cycle constitutes a major feature of Alzheimer's disease (AD). The maintenance of circadian rhythmicity is regulated by endogenous clock genes and a number of external Zeitgebers, including light ...
@corresponding, Author, Bellanti, Francesco, Blonda, Maria, Calcagnini, Silvio, Cassano, Tommaso, Gaetani, Silvana, Giudetti, Anna Maria, Iannelli, Giuseppina, Mazzoccoli, Gianluigi, Romano, Adele, Serviddio, Gaetano, Tamborra, Rosanna, Vendemiale, Gianluigi, Villani, Rosanna, Vinciguerra, Manlio   +14 more
core   +1 more source

Brain-specific rescue of Clock reveals system-driven transcriptional rhythms in peripheral tissue.

PLoS Genetics, 2012
The circadian regulatory network is organized in a hierarchical fashion, with a central oscillator in the suprachiasmatic nuclei (SCN) orchestrating circadian oscillations in peripheral tissues.
Michael E Hughes, Hee-Kyung Hong, Jason L Chong, Alejandra A Indacochea, Samuel S Lee, Michael Han, Joseph S Takahashi, John B Hogenesch   +7 more
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

A network of pro-inflammatory genes repressed by clock signalling in bronchial epithelium

ERJ Open Research
Background Circadian rhythms are biological cycles that regulate various physiological processes, including immune responses, tissue repair and oxidative stress. Previous studies indicated a role for distorted circadian signalling in COPD.
Xiaopeng Li, Karthi Srikanthan, Siti Farah Rahmawati, Dirk-Jan Slebos, Pallav L. Shah, Philip J. Johnson, Loes E.M. Kistemaker, Anika Nagelkerke, Reinoud Gosens   +8 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Circadian control of interferon-sensitive gene expression in murine skin. [PDF]

, 2020
The circadian clock coordinates a variety of immune responses with signals from the external environment to promote survival. We investigated the potential reciprocal relationship between the circadian clock and skin inflammation.
Andersen, Bogi, Dragan, Morgan, Greenberg, Elyse Noelani, Gudjonsson, Johann E, Jin, Suoqin, Marshall, Michaela Ellen, Nie, Qing, Takahashi, Joseph S, Tsoi, Lam C, Venkatesh, Sanan   +9 more
core   +2 more sources

The Circadian Clock Gene BMAL1 Coordinates Intestinal Regeneration [PDF]

Cellular and Molecular Gastroenterology and Hepatology, 2017
The gastrointestinal syndrome is an illness of the intestine caused by high levels of radiation. It is characterized by extensive loss of epithelial tissue integrity, which initiates a regenerative response by intestinal stem and precursor cells. The intestine has 24-hour rhythms in many physiological functions that are believed to be outputs of the ...
Kyle Stokes, Abrial Cooke, Hanna Chang, David R. Weaver, David T. Breault, Phillip Karpowicz   +5 more
openaire   +3 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source