Results 91 to 100 of about 125,855 (308)
Exogenous and Endogenous Components in Circadian Rhythms [PDF]
, 1960 Jürgen Aschoff
openalex +1 more source
Eukaryogenesis From FECA to LECA: Radical Steps Along the Way
BioEssays, EarlyView.How did the last eukaryotic common ancestor (LECA) population evolve? Recent evidence shows an Asgard archaeon‐like organism acquiring a bacterium, the future mitochondrion, going from symbiosis to endosymbiosis. I postulate that almost all salient LECA characteristics could have resulted from the ensuing enhanced ATP generation and internal reactive ...
Dave Speijer
wiley +1 more source
Frontiers in EndocrinologyBackgroundPolycystic ovary syndrome (PCOS) has been extensively studied as a common female endocrine disease. In recent years, the relationship between circadian rhythm and PCOS has gradually drawn attention, although the precise nature of this ...
Wenjia Li +10 more
doaj +1 more source
Circadian Rhythms and the Circadian Organization of Living Systems [PDF]
, 1960 Colin S. Pittendrigh
openalex +1 more source
Neurologic Clinics, 2019 In mammals, genetic influences of circadian rhythms occur at many levels. A set of core "clock genes" have been identified that form a feedback loop of gene transcription and translation. The core genetic clockwork generates circadian rhythms in cells throughout the body.
Martha Hotz Vitaterna +2 more
openaire +4 more sources
Integrating Astrocytes in the Sleep–Wake Cycle: The Time Is Now
BioEssays, EarlyView.Astrocytes actively regulate sleep homeostatic and circadian rheostatic processes, underpinning the sleep–wake cycle. By acting as context‐dependent integrators of internal state and rhythmic environmental inputs, they modulate the encoding properties of neuronal circuitries and contribute to salient temporal representations in the brain.
Marco Brancaccio
wiley +1 more source
Targeting Cryptochromes in Chronic Diseases
Cell Biology International, EarlyView.ABSTRACT The circadian clock generates 24‐h molecular rhythms through transcription–translation negative feedback loops (TTFLs) and regulates daily physiological processes such as sleep–wake cycles, body temperature, hormone secretion, metabolism, and immune function.
Takuro Toda, Tsuyoshi Hirota
wiley +1 more source
Canadian Journal of Statistics, EarlyView.Abstract Modern longitudinal data from wearable devices consist of biological signals at high‐frequency time points. Distributed statistical methods have emerged as a powerful tool to overcome the computational burden of estimation and inference with large data, but methodology for distributed functional regression remains limited.
Cole Manschot, Emily C. Hector
wiley +1 more source
Clinical Pharmacology in Drug Development, EarlyView.Abstract Bexicaserin (LP352) is a selective 5‐hydroxytryptamine 2C (5‐HT2C) superagonist in development for the treatment of seizures in developmental and epileptic encephalopathies (DEEs). This double‐blind, placebo‐controlled, single ascending dose (SAD) Phase 1 study aimed to assess the safety, tolerability, and pharmacokinetic (PK) and ...
Rosa Chan +6 more
wiley +1 more source