Results 71 to 80 of about 346,110 (185)

Evaluation of QT Liability for PF‐05251749 in the Presence of Potential Circadian Rhythm Modification

CPT: Pharmacometrics & Systems Pharmacology, 2020
PF‐05251749 is a dual inhibitor of casein kinase 1 δ/ε, key regulators of circadian rhythm. As a result of its mechanism of action, PF‐05251749 may also change the heart rate corrected QT (QTc) circadian rhythm, which may confound detection of drug ...
Yeamin Huh, Danny Chen, Steve Riley, Cheng Chang, Timothy Nicholas   +4 more
doaj   +1 more source

A Circadian Clock-Regulated Toggle Switch Explains AtGRP7 and AtGRP8 Oscillations in Arabidopsis thaliana [PDF]

, 2013
Schmal C, Reimann P, Staiger D. A Circadian Clock-Regulated Toggle Switch Explains AtGRP7 and AtGRP8 Oscillations in Arabidopsis thaliana. PLoS Computational Biology. 2013;9(3): e1002986.The circadian clock controls many physiological processes in higher
Staiger Dorothee, Peter Reimann, Reimann, Peter, Schmal, Christoph, Dorothee Staiger (40787), Christoph Schmal, Schmal Christoph, Reimann Peter, Peter Reimann (395937), Staiger, Dorothee, Dorothee Staiger, Christoph Schmal (395936)   +11 more
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Circadian Rhythm Disruption Exacerbates Autoimmune Uveitis: The Essential Role of PER1 in Treg Cell Metabolic Support for Stability and Function

Advanced Science
Circadian rhythm plays a critical role in the progression of autoimmune diseases. While our previous study demonstrated the therapeutic effects of melatonin in experimental autoimmune uveitis, the involvement of circadian rhythm remained unclear. Using a
Wenjie Zhu, Guanyu Chen, Zhiqiang Xiao, Minzhen Wang, Zhuang Li, Yuxun Shi, Xiaohui Luo, Zuoyi Li, Haixiang Huang, Xiaoqing Chen, Lingyi Liang, Dan Liang   +11 more
doaj   +1 more source

Quantitative analysis of regulatory flexibility under changing environmental conditions [PDF]

, 2010
The circadian clock controls 24-h rhythms in many biological processes, allowing appropriate timing of biological rhythms relative to dawn and dusk. Known clock circuits include multiple, interlocked feedback loops.
Andrew J Millar, Paul E Brown, David A Rand, Kirsten Knox, Knox, Kirsten, Thomson, Adrian W, Akman, Ozgur E, Lumsden, Peter J, Millar, A. J., Ozgur E Akman, Edwards, Kieron D, Brown, Paul E., Rand, D. A., Alexandra Pokhilko, Edwards, Kieron D., Thomson, Adrian W., Rand, David A, Lumsden, P. J., Nagy, Ferenc, Laszlo Kozma‐Bognar, Ra Pokhilko, Adrian W Thomson, Peter J Lumsden, Akman, Ozgur E., Kozma-Bognar, Laszlo, Kieron D Edwards, Ferenc Nagy, Lumsden, Peter J., Pokhilko, Alexandra, Brown, Paul E, Rand, David A., Millar, Andrew J; id_orcid, David A R, Millar, Andrew J., Laszlo Kozma-bognar   +34 more
core   +1 more source

Impact of Lactobacillus johnsonii on glycemic control and lipid metabolism in type 2 diabetes with circadian disruption

Scientific Reports
Although most patients with type 2 diabetes mellitus (T2DM) and circadian rhythm disruption have poor blood glucose control, a fraction of patients with T2DM and circadian rhythm disruption who still have good blood glucose control. Previous studies have
Yang Yan, Wang Zhen, Shen Hongxia, Shi Zhenhong, Mei Xianghui, Wu Na, Sun Li, Wang Defeng   +7 more
doaj   +1 more source

Circadian rhythmicity and light sensitivity of the zebrafish brain [PDF]

, 2013
Light is important for entraining circadian rhythms, which regulate a wide range of biological processes. Zebrafish have directly light responsive tissues (Whitmore et al 2000) and are thus a useful vertebrate model for circadian rhythmicity and light ...
Moore, HA
core  

The Prognostic Significance of Sleep and Circadian Rhythm for Myocardial Infarction Outcomes: Case-Control Study

Journal of Medical Internet Research
BackgroundMyocardial infarction (MI) is a medical emergency resulting from coronary artery occlusion. Patients with acute MI often experience disturbed sleep and circadian rhythm. Most previous studies assessed the premorbid sleep
Wei-Chih Chin, Pao-Hsien Chu, Lung-Sheng Wu, Kuang-Tso Lee, Chen Lin, Chien-Te Ho, Wei-Sheng Yang, I-Hang Chung, Yu-Shu Huang   +8 more
doaj   +1 more source

Metals and Circadian Rhythms [PDF]

, 2017
Circadian rhythms describe the behavioral and physiological changes that occur in living organisms in order to attune to a 24 hour cycle of day and night. The most striking aspect of circadian function is the sleep-wake cycle, however many other physiological processes are regulated in 24 hour oscillations, including blood pressure, body temperature ...
Nancy L, Parmalee, Michael, Aschner
openaire   +2 more sources

Asynchronous Rhythm of Steroidogenic Factor 1 and Period Homolog 2 mRNA Expression in Mouse Y1 Adrenocorticol Tumor Cells [PDF]

, 2010
The relationship between the expression of Steroidogenic factor 1 (Sf1) and the circadian-related gene, period homolog 2 (Per2), in the adrenal cortex is still unknown.
Toshihiko Yanase, Kouichirou Sonoda, Taijiro Okabe, Kenji Ohe, Ryoichi Takayanagi, Masatoshi Nomura, Koichi Node, Makoto Akashi, Koichi Oba, Hajime Nawata   +9 more
core  

The TIME FOR COFFEE gene maintains the amplitude and timing of Arabidopsis circadian clocks [PDF]

, 2003
Plants synchronize developmental and metabolic processes with the earth's 24-h rotation through the integration of circadian rhythms and responses to light.
Amasino, R., Hanano, S., Sung, S., Millar, A., Davis, S. J., McWatters, Harriet G, Sung, S, Doyle, M., Bastow, R. M., Hibberd, V, Doyle, MR, Millar, A. J., Sung, Sibum, Bastow, Ruth M, Davis, SJ, Bastow, R., McWatters, H., Davis, Seth J, Hanano, Shigeru, Hibberd, Victoria, Millar, AJ, Amasino, RM, Halliday, K., Doyle, M. R., Davis, S., Hibberd, V., Sung, S. B., Halliday, Karen J, Hall, Anthony, Amasino, Richard M, Doyle, Mark R, Amasino, R. M., Halliday, K. J., Bastow, RM, McWatters, H. G., Hanano, S, Millar, Andrew J; id_orcid, Halliday, KJ, Hall, A., Mcwatters, Harriet, Hall, A   +40 more
core   +1 more source