Results 71 to 80 of about 93,323 (251)

Diabetes Alters Diurnal Rhythm of Electroretinogram in db/db Mice [PDF]

open access: yes, 2019
Diabetic retinopathy (DR) is the most common complications of diabetes and a leading cause of blindness in the United States. The retinal neuronal changes precede the vascular dysfunction observed in DR.
Bhatwadekara, Ashay D.   +3 more
core  

Circadian rhythms of proliferation events in two mouse carcinomas [PDF]

open access: yes, 2015
We studied the index of DNA synthesis (DNAs) of two cellular carcinomas: the hepatocellular ES12a and the mammary TN60 of mice, throughout one circadian cycle.
Andrini, Laura Beatríz   +6 more
core   +1 more source

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

open access: yesAdvanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu   +11 more
wiley   +1 more source

Epilepsy Occurrence and Circadian Rhythm: A Bibliometrics Study and Visualization Analysis via CiteSpace

open access: yesFrontiers in Neurology, 2020
Objective: This study aimed to review the research status and to demonstrate the hot spots and frontiers of epilepsy and circadian rhythm via CiteSpace.Method: We searched Web of Science (WoS) for studies related to epilepsy and circadian rhythm from ...
Dongling Zhong   +5 more
doaj   +1 more source

On the Excretion of Urinary 17-Hydroxycorticosteroids (17-OHCS) in Antarctic Region [PDF]

open access: yes, 1976
In the study of the effect of chilliness and the tendency of cryodomestication, the urinary output of 17-Hydroxycorticosteroids (17-OHCS) was used, and its circadian rhythm was investigated.
Tetsuo Oda
core   +1 more source

Circadian regulation of reproduction: From gamete to offspring [PDF]

open access: yes, 2013
P01326625; Grants: GNT0519315Few challenges are more critical to the survival of a species than reproduction. To ensure reproductive success, myriad aspects of physiology and behaviour need to be tightly orchestrated within the animal, as well as timed ...
Boden, M., Kennaway, D., Varcoe, T.
core   +1 more source

Сон в Антарктиде: от проблем с засыпанием до понимания проблем [PDF]

open access: yes, 2020
From the fi rst expeditions, adaptation to the harsh environment of Antarctica, the expeditionists complained of a trouble sleeping. During a long stay on the continent, the polar explorers are exposed to a large number of extreme environmental factors ...
Бабийчук, Г.А.   +4 more
core   +1 more source

Tetrahedral DNA Nanostructure‐Based Biomimetic Nanovesicles Attenuate Sepsis‐Associated ARDS by Suppressing Glycolysis via the BMAL1/PFKFB3 Axis

open access: yesAdvanced Science, EarlyView.
Upon inhalation, RM@TNT could persist long‐term in the diseased lungs, while undergoing disintegration to release TNT specifically within the ROS‐rich pathological microenvironments of SA‐ARDS. The released TNT was then precisely delivered to AMs via Tuftsin, where it released Nob intracellularly to activate BMAL1 expression, thus inhibiting AM ...
Yunlong Zhang   +23 more
wiley   +1 more source

Evaluation of QT Liability for PF‐05251749 in the Presence of Potential Circadian Rhythm Modification

open access: yesCPT: Pharmacometrics & Systems Pharmacology, 2020
PF‐05251749 is a dual inhibitor of casein kinase 1 δ/ε, key regulators of circadian rhythm. As a result of its mechanism of action, PF‐05251749 may also change the heart rate corrected QT (QTc) circadian rhythm, which may confound detection of drug ...
Yeamin Huh   +4 more
doaj   +1 more source

An ingestible temperature-transmitter [PDF]

open access: yes, 1972
Pill-sized transmitter measures deep body temperature in studies of circadian rhythm and indicates general health.
Fryer, T. B., Pope, J. M., Sandler, H.
core   +1 more source

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