Results 51 to 60 of about 346,110 (185)

The impact of short-term changes in sleeping and eating patterns on glucometabolic health and gut microbiota in healthy young adults: a proof-of-concept controlled feeding study

Food Science and Human Wellness
Epidemiological studies showed that night workers are at higher risk of developing chronic metabolic diseases. However, no study has investigated the changes in circadian rhythms caused by a combined effect of sleep and diet in a real-life setting on ...
Jiehua Chen, Ruijie Zhang, Chao Zhou, Louise Weiwei Lu, Dana Feng, Haiqiao Zou, Ran Gao, Xinying Zhang, Peiyi Chen, Jiayue Zhu, Haoxie Xu, Nina Zeng, Cijuan Zhang, Bin Liu, Mingfu Wang, Qian Ge, Caiqun Ouyang, Feng Chen   +17 more
doaj   +1 more source

CHRONO and DEC1/DEC2 compensate for lack of CRY1/CRY2 in expression of coherent circadian rhythm but not in generation of circadian oscillation in the neonatal mouse SCN

Scientific Reports, 2021
Clock genes Cry1 and Cry2, inhibitory components of core molecular feedback loop, are regarded as critical molecules for the circadian rhythm generation in mammals.
Daisuke Ono, Ken-ichi Honma, Christoph Schmal, Toru Takumi, Takeshi Kawamoto, Katsumi Fujimoto, Yukio Kato, Sato Honma   +7 more
doaj   +1 more source

Disruption in the regulation of casein kinase 2 in circadian rhythm leads to pathological states: cancer, diabetes and neurodegenerative disorders

Frontiers in Molecular Neuroscience, 2023
IntroductionCircadian rhythm maintains the sleep–wake cycle in biological systems. Various biological activities are regulated and modulated by the circadian rhythm, disruption of which can result in onset of diseases.
Md. Zubbair Malik, Mohammed Dashti, Yasmin Fatima, Arshad Channanath, Sumi Elsa John, R. K. Brojen Singh, Fahd Al-Mulla, Thangavel Alphonse Thanaraj   +7 more
doaj   +1 more source

Galactose-modified small molecule modulator targets RORα to enhance circadian rhythm and alleviate periodontitis-associated alveolar bone loss

Bone Research
Circadian rhythm disorders are associated with dysfunction in inflammatory diseases, and targeted regulation of the circadian rhythm could serve as an intervention strategy. RORα/γ, as core components of circadian clock genes, positively modulate the key
Guangxia Feng, Zhiwen Liao, Yifan Wang, Qingming Tang, Nayun Li, Cheng Li, Yuqing Liu, Renlong Liu, Mingjian Cui, Wenjie Fan, Ying Yin, Lingkui Meng, Jing Zeng, Zetao Chen, Guanzheng Luo, Peng Xiang, Qian Wan, Lili Chen   +17 more
doaj   +1 more source

Klebsiella pneumoniae alters zebrafish circadian rhythm via inflammatory pathways and is dependent on light cues

Heliyon
Klebsiella pneumoniae is an opportunistic pathogen causing severe infections. The circadian rhythm is the internal rhythm mechanism of an organism and plays an important role in coping with changes in the 24-h circadian rhythm.
Hui Ding, Xiao-chun Chen, Lin Wan, Ying-ying Zhang, Xiao-hong Rui, Tian He, Jun Liu, Zhong-bo Shang   +7 more
doaj   +1 more source

Circadian Blood Pressure Rhythm in Cardiovascular and Renal Health and Disease

Biomolecules, 2021
Blood pressure (BP) follows a circadian rhythm, it increases on waking in the morning and decreases during sleeping at night. Disruption of the circadian BP rhythm has been reported to be associated with worsened cardiovascular and renal outcomes ...
Jiayang Zhang, Ruoyu Sun, Tingting Jiang, Guangrui Yang, Lihong Chen   +4 more
doaj   +1 more source

The Neurobiology of Circadian Rhythms

Psychiatric Clinics of North America, 2015
There is a growing recognition that the coordinated timing of behavioral, physiologic, and metabolic circadian rhythms is a requirement for a healthy body and mind. In mammals, the primary circadian oscillator is the hypothalamic suprachiasmatic nucleus (SCN), which is responsible for circadian coordination throughout the organism. Temporal homeostasis
Sollars, Patricia J., Pickard, Gary E.
openaire   +3 more sources

Circadian rhythms and diabetes [PDF]

Journal of Diabetes Investigation, 2011
All free‐living organisms are regulated by the 24‐h light and dark cycle produced by Earth’s rotation. In mammals, circadian rhythms are indispensble for the regulation of physiological and biochemical processes in the body. In 1972, the suprachiasmatic nucleus was shown to be required for daily rhythms in animal behavior1.
Kurose, Takeshi, Yabe, Daisuke, Inagaki, Nobuya   +2 more
openaire   +2 more sources

The contributions of interlocking loops and extensive nonlinearity to the properties of circadian clock models [PDF]

, 2010
Sensitivity and robustness are essential properties of circadian clock systems, enabling them to respond to the environment but resist noisy variations. These properties should be recapitulated in computational models of the circadian clock.
Andrew J Millar, Painter, Kevin J., Saithong Treenut, Saithong T., Painter K. J., Painter Kevin J., Saithong, Treenut, Kevin J Painter, Millar Andrew J., Andrew J. Millar, Millar A. J., Millar, Andrew J; id_orcid, Treenut Saithong, Painter, Kevin J, Millar, Andrew J., Kevin J. Painter   +15 more
core   +1 more source

Circadian rhythm perturbation causes IBS-like characteristics and altered fecal metabolome in mice

BMC Microbiology
Background Circadian rhythm disturbance is associated with functional gastrointestinal disorders such as irritable bowel syndrome (IBS). This study aimed to explore the effects of dysregulated circadian rhythm on visceral sensitivity, colonic ...
Gaichao Hong, Yajuan Zhao, Jieru Zhou, Lilin Hu, Gangping Li, Yu Jin   +5 more
doaj   +1 more source