Results 81 to 90 of about 117,415 (263)
Angewandte Chemie International Edition, EarlyView.Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann +10 more
wiley +1 more source
A review of the impact of circadian rhythm on motor function in stroke recovery patients
Frontiers in NeurologyStroke is a leading cause of motor impairment, significantly affecting patients’ quality of life during the recovery phase. Motor function recovery after stroke is influenced by multiple factors, among which circadian rhythm have recently garnered ...
Hao Zhou +7 more
doaj +1 more source
Animal Research and One Health, EarlyView.Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang +6 more
wiley +1 more source
Animal Research and One Health, EarlyView.Depression accelerates tumor growth by dysregulation of tumor immune microenvironment. (A) Modeling methods: Subcutaneous tumor models were established under chronic unpredictable mild stress conditions, including cold swimming, physical restraint, and food/water deprivation, leading to increased tumor growth.
Yakun Ren +6 more
wiley +1 more source
Photoreceptors for Circadian Rhythms
, 1979 Uploaded by Plazi for TaxoDros. We do not have abstracts.
openaire +1 more source
Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease
Arthritis &Rheumatology, EarlyView.Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel +12 more
wiley +1 more source
JMIR Medical InformaticsBackgroundWearable devices are increasingly used for monitoring health and detecting digital biomarkers related to chronic diseases such as metabolic syndrome (MetS).
Jeong-Kyun Kim, Sujeong Mun, Siwoo Lee
doaj +1 more source
Development of salivary cortisol circadian rhythm in preterm infants.
PLoS ONE, 2017 ObjectivesTo investigate at what age preterm infants develop a salivary cortisol circadian rhythm and identify whether it is dependent on gestational age and/or postnatal age.
Katrin Ivars +5 more
doaj +1 more source
A survey on the teaching of introductory nervous system content in undergraduate courses
Anatomical Sciences Education, EarlyView.Abstract Teaching introductory or foundation level concepts about anatomy and physiology of the nervous system to undergraduate students presents a conundrum for educators—how to provide students with sufficient knowledge for a successful learning experience and outcome without overwhelming students and impacting student progression and retention.
Gabrielle Todd +2 more
wiley +1 more source
Task‐Related Aperiodic EEG (1/f) Activity in Autism
Autism Research, EarlyView.ABSTRACT Autism has been hypothesized to involve atypicalities in the balance between neural excitation and inhibition (E/I). Aperiodic EEG activity, characterized by the 1/f exponent of the power spectrum, provides a proxy of cortical E/I dynamics. However, prior studies in autism report mixed findings regarding the slope of aperiodic activity.
Magdalena Matyjek +3 more
wiley +1 more source