Results 91 to 100 of about 93,323 (251)

Circadian Rhythm Disruption Exacerbates Autoimmune Uveitis: The Essential Role of PER1 in Treg Cell Metabolic Support for Stability and Function

Advanced Science
Circadian rhythm plays a critical role in the progression of autoimmune diseases. While our previous study demonstrated the therapeutic effects of melatonin in experimental autoimmune uveitis, the involvement of circadian rhythm remained unclear. Using a
Wenjie Zhu, Guanyu Chen, Zhiqiang Xiao, Minzhen Wang, Zhuang Li, Yuxun Shi, Xiaohui Luo, Zuoyi Li, Haixiang Huang, Xiaoqing Chen, Lingyi Liang, Dan Liang   +11 more
doaj   +1 more source

Automating AI Discovery for Biomedicine Through Knowledge Graphs and Large Language Models Agents

Advanced Intelligent Discovery, EarlyView.
This work proposes a novel framework that automates biomedical discovery by integrating knowledge graphs with multiagent large language models. A biologically aligned graph exploration strategy identifies hidden pathways between biomedical entities, and specialized agents use this pathway to iteratively design AI predictors and wet‐lab validation ...
Naafey Aamer, Muhammad Nabeel Asim, Shan Munir, Andreas Dengel   +3 more
wiley   +1 more source

Machine Learning‐Driven Digital Twin of a Field‐Effect Transistor‐Based Hormone Biosensor for Real‐Time Estradiol Monitoring

Advanced Intelligent Systems, EarlyView.
A machine learning‐driven digital twin simulates an aptamer‐functionalized BioFET measuring 17β‐estradiol. Real‐time Isd signals are processed, features are extracted, and trained models estimate hormone concentration. In parallel, a one‐step‐ahead forward model learns biosensor dynamics and generates realistic synthetic signals, enabling in silico ...
Anastasiia Gorelova, Alexandra Parichenko, Shirong Huang, Santiago Melia, Gianaurelio Cuniberti   +4 more
wiley   +1 more source

The Prognostic Significance of Sleep and Circadian Rhythm for Myocardial Infarction Outcomes: Case-Control Study

Journal of Medical Internet Research
BackgroundMyocardial infarction (MI) is a medical emergency resulting from coronary artery occlusion. Patients with acute MI often experience disturbed sleep and circadian rhythm. Most previous studies assessed the premorbid sleep
Wei-Chih Chin, Pao-Hsien Chu, Lung-Sheng Wu, Kuang-Tso Lee, Chen Lin, Chien-Te Ho, Wei-Sheng Yang, I-Hang Chung, Yu-Shu Huang   +8 more
doaj   +1 more source

Circadian rhythms and hormonal homeostasis: Pathophysiological implications [PDF]

, 2017
Over recent years, a deeper comprehension of the molecular mechanisms that control biological clocks and circadian rhythms has been achieved. In fact, many studies have contributed to unravelling the importance of the molecular clock for the regulation ...
Bruscalupi, Giovannella, Gnocchi, Davide
core   +2 more sources

Time‐course characterization of intraocular pressure in murine steroid‐induced ocular hypertension: Effects of route, schedule, and concentration

Animal Models and Experimental Medicine, EarlyView.
Steroid‐induced ocular hypertension is a useful mouse model for glaucoma, but published work rarely quantifies how route, dose, and schedule shape the intraocular pressure (IOP) time‐course—hindering reproducibility and forcing labs to pilot protocols.
Nicholas Y. Q. Tan, Sai Bo Bo Tun, Hla Myint Htoon, Veluchamy Amutha Barathi, Tina T. Wong   +4 more
wiley   +1 more source

Solving the mystery of human sleep schedules one mutation at a time. [PDF]

, 2013
Sleep behavior remains one of the most enigmatic areas of life. The unanswered questions range from "why do we sleep?" to "how we can improve sleep in today's society?" Identification of mutations responsible for altered circadian regulation of human ...
Fu, Ying-Hui, Hallows, William C, Ptáček, Louis J   +2 more
core   +1 more source

Sex as a biological variable in nonclinical studies: Bridging scientific rigor, animal welfare, and regulatory expectations

Animal Models and Experimental Medicine, EarlyView.
Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma, Masaki Watanabe, Nobuya Sasaki   +2 more
wiley   +1 more source

Circadian Rhythm, Lifestyle and Health: A Narrative Review

Iranian Journal of Public Health, 2018
Background: The circadian rhythm regulation plays a crucial role in people`s healthy lives affected by factors consisting of cosmic events related to the universe and earth, environmental factors (light, night and day duration, seasons) and lifestyles ...
Dariush FARHUD, Zahra ARYAN
doaj  

Serotonin and corticosterone rhythms in mice exposed to cigarette smoke and in patients with COPD:implication for COPD-associated neuropathogenesis [PDF]

, 2014
The circadian timing system controls daily rhythms of physiology and behavior, and disruption of clock function can trigger stressful life events. Daily exposure to cigarette smoke (CS) can lead to alteration in diverse biological and physiological ...
A Agusti, A Hida, A Mykletun, A Papi, A Thomas, C Laurin, CJ Murray, CJ Rosen, CL Tsai, CM Ciarleglio, CM Kim, CM Spengler, DA Lewis, E Repapi, EJ Wagena, EJ Wagena, Elizabeth Lyda, F Di Marco, Firoze Khan, FM Botelho, FW Turek, G Cavadini, GE Tafet, GJ Borsboom, GV Carr, H Bando, H Chen, H Chen, H Chen, H Chen, H Hadden, H Yao, H Yao, H Yao, HC Atkinson, Hongwei Yao, I Rahman, I Wilson, Irfan Rahman, Isaac K. Sundar, J Liu, JA Mohawk, JE Gibbs, JL Malisch, JM Gierisch, JM Launay, JM Murphy, JS Takahashi, JW Hwang, K Lutfy, KA Lamia, KF Rabe, LE Kalynchuk, M Ishikawa, Michael T. Sellix, MW Zhang, NA Hanania, OP Soldin, P Dome, Patricia J. Sime, PD Altland, PJ Barnes, PJ Sollars, RA Prosser, RY Moore, S Eddahibi, S Gebel, SA Antoniu, SH Yoo, SK Droste, T Ishii, T Sekiduka-Kumano, U Albrecht, W Stinn, WB Essman, WK Lau, WK Lau, WT McNicholas, Y Ban, Yadi Huang   +79 more
core   +2 more sources