Results 31 to 40 of about 131,367 (307)

Circadian Blood Pressure Rhythm in Cardiovascular and Renal Health and Disease

Biomolecules, 2021
Blood pressure (BP) follows a circadian rhythm, it increases on waking in the morning and decreases during sleeping at night. Disruption of the circadian BP rhythm has been reported to be associated with worsened cardiovascular and renal outcomes ...
Jiayang Zhang, Ruoyu Sun, Tingting Jiang, Guangrui Yang, Lihong Chen   +4 more
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Closed-loop cascade nanozyme strategy for mutually reinforced catalytic and mild-temperature photothermal therapeutic effects

Journal of Nanobiotechnology
Nanocatalysis coupled with photothermal therapy is a potent anti-cancer approach, yet its clinical utility is limited by low concentration of tumor substrate, redox interference, and risks of overheating normal tissues.
Fan Yang, Chunyu Yan, Nannan Li, Xinxiu Jiang, Baojie Du, Peirong Bai, Liping Li, Ruiping Zhang   +7 more
doaj   +1 more source

The impact of short-term changes in sleeping and eating patterns on glucometabolic health and gut microbiota in healthy young adults: a proof-of-concept controlled feeding study

Food Science and Human Wellness
Epidemiological studies showed that night workers are at higher risk of developing chronic metabolic diseases. However, no study has investigated the changes in circadian rhythms caused by a combined effect of sleep and diet in a real-life setting on ...
Jiehua Chen, Ruijie Zhang, Chao Zhou, Louise Weiwei Lu, Dana Feng, Haiqiao Zou, Ran Gao, Xinying Zhang, Peiyi Chen, Jiayue Zhu, Haoxie Xu, Nina Zeng, Cijuan Zhang, Bin Liu, Mingfu Wang, Qian Ge, Caiqun Ouyang, Feng Chen   +17 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Galactose-modified small molecule modulator targets RORα to enhance circadian rhythm and alleviate periodontitis-associated alveolar bone loss

Bone Research
Circadian rhythm disorders are associated with dysfunction in inflammatory diseases, and targeted regulation of the circadian rhythm could serve as an intervention strategy. RORα/γ, as core components of circadian clock genes, positively modulate the key
Guangxia Feng, Zhiwen Liao, Yifan Wang, Qingming Tang, Nayun Li, Cheng Li, Yuqing Liu, Renlong Liu, Mingjian Cui, Wenjie Fan, Ying Yin, Lingkui Meng, Jing Zeng, Zetao Chen, Guanzheng Luo, Peng Xiang, Qian Wan, Lili Chen   +17 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Klebsiella pneumoniae alters zebrafish circadian rhythm via inflammatory pathways and is dependent on light cues

Heliyon
Klebsiella pneumoniae is an opportunistic pathogen causing severe infections. The circadian rhythm is the internal rhythm mechanism of an organism and plays an important role in coping with changes in the 24-h circadian rhythm.
Hui Ding, Xiao-chun Chen, Lin Wan, Ying-ying Zhang, Xiao-hong Rui, Tian He, Jun Liu, Zhong-bo Shang   +7 more
doaj   +1 more source

Current role and future perspectives of electroacupuncture in circadian rhythm regulation

Heliyon, 2023
In recent years, in-depth research on chronobiology has been conducted, and the circadian rhythm has become a new target for the treatment of diseases. Circadian rhythms are closely related to the normal physiological functions of organisms.
Min Yuan, Wei Lu, Ying Lan, Jiaen Yang, Jun Yin, Dong Wang   +5 more
doaj   +1 more source