Results 31 to 40 of about 125,855 (308)

CHRONO and DEC1/DEC2 compensate for lack of CRY1/CRY2 in expression of coherent circadian rhythm but not in generation of circadian oscillation in the neonatal mouse SCN

Scientific Reports, 2021
Clock genes Cry1 and Cry2, inhibitory components of core molecular feedback loop, are regarded as critical molecules for the circadian rhythm generation in mammals.
Daisuke Ono, Ken-ichi Honma, Christoph Schmal, Toru Takumi, Takeshi Kawamoto, Katsumi Fujimoto, Yukio Kato, Sato Honma   +7 more
doaj   +1 more source

Disruption in the regulation of casein kinase 2 in circadian rhythm leads to pathological states: cancer, diabetes and neurodegenerative disorders

Frontiers in Molecular Neuroscience, 2023
IntroductionCircadian rhythm maintains the sleep–wake cycle in biological systems. Various biological activities are regulated and modulated by the circadian rhythm, disruption of which can result in onset of diseases.
Md. Zubbair Malik, Mohammed Dashti, Yasmin Fatima, Arshad Channanath, Sumi Elsa John, R. K. Brojen Singh, Fahd Al-Mulla, Thangavel Alphonse Thanaraj   +7 more
doaj   +1 more source

Chronobiology and Mood Disorders [PDF]

Psikiyatride Güncel Yaklaşımlar, 2011
Living organizms show cyclic rhythmicity in a variety of physiological, hormonal, behavioral, and psychological processes. Sleep-wake cycles, body temperature, hormone levels, mood and cognition display a circadian rhythm in humans.
Yavuz Selvi, Lutfullah Besiroglu, Adem Aydin   +2 more
doaj  

Circadian Rhythm Sleep Disorders [PDF]

Psikiyatride Güncel Yaklaşımlar, 2016
The circadian rhythm sleep disorders define the clinical conditions where sleep and ndash;wake rhythm is disrupted despite optimum environmental and social conditions.
Erhan Akinci, Fatma Ozlem Orhan
doaj   +1 more source

Circadian Blood Pressure Rhythm in Cardiovascular and Renal Health and Disease

Biomolecules, 2021
Blood pressure (BP) follows a circadian rhythm, it increases on waking in the morning and decreases during sleeping at night. Disruption of the circadian BP rhythm has been reported to be associated with worsened cardiovascular and renal outcomes ...
Jiayang Zhang, Ruoyu Sun, Tingting Jiang, Guangrui Yang, Lihong Chen   +4 more
doaj   +1 more source

The impact of short-term changes in sleeping and eating patterns on glucometabolic health and gut microbiota in healthy young adults: a proof-of-concept controlled feeding study

Food Science and Human Wellness
Epidemiological studies showed that night workers are at higher risk of developing chronic metabolic diseases. However, no study has investigated the changes in circadian rhythms caused by a combined effect of sleep and diet in a real-life setting on ...
Jiehua Chen, Ruijie Zhang, Chao Zhou, Louise Weiwei Lu, Dana Feng, Haiqiao Zou, Ran Gao, Xinying Zhang, Peiyi Chen, Jiayue Zhu, Haoxie Xu, Nina Zeng, Cijuan Zhang, Bin Liu, Mingfu Wang, Qian Ge, Caiqun Ouyang, Feng Chen   +17 more
doaj   +1 more source

Aging and circadian rhythms [PDF]

Current Opinion in Insect Science, 2015
Circadian clocks are cell-autonomous molecular feedback loops that generate daily rhythms in gene expression, cellular functions, physiological processes and behavior. The mechanisms of circadian clocks are well understood in young fruit flies Drosophila melanogaster, but less is known about how circadian system changes during organismal aging. Similar
Dani M Long, Jadwiga M. Giebultowicz
openaire   +3 more sources

Assessing a Mitochondrial Disease Treatment via a Novel Statistical Technique for Accelerometer Data

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Therapeutic development for mitochondrial diseases, rare genetic disorders with pathogenic defects of oxidative phosphorylation, is hindered by unsatisfactory outcome measures. To address this problem, we provide the first clinical application of a novel, bias‐adjusted outcome measure of acceleration across a range of subjects ...
Ian W. McKeague, Kristin Engelstad, Yue Ge, Amber Tucker, Shufang Li, Jasim Uddin, Ziwei Zhao, John L. P. Thompson, Michio Hirano   +8 more
wiley   +1 more source

Closed-loop cascade nanozyme strategy for mutually reinforced catalytic and mild-temperature photothermal therapeutic effects

Journal of Nanobiotechnology
Nanocatalysis coupled with photothermal therapy is a potent anti-cancer approach, yet its clinical utility is limited by low concentration of tumor substrate, redox interference, and risks of overheating normal tissues.
Fan Yang, Chunyu Yan, Nannan Li, Xinxiu Jiang, Baojie Du, Peirong Bai, Liping Li, Ruiping Zhang   +7 more
doaj   +1 more source

Circadian Rhythm Disruption [PDF]

AAOHN Journal, 2011
The circadian rhythm is a 24-hour cycle subject to outside influences. Disruptions of this cycle (e.g., shift work and international travel) have implications for occupational health nurses.
openaire   +2 more sources