Results 301 to 310 of about 52,173 (326)

Challenges and opportunities for circRNA identification and delivery

Critical reviews in biochemistry and molecular biology, 2023
Circular RNAs (circRNAs) are evolutionarily conserved noncoding RNAs with tissue-specific expression patterns, and exert unique cellular functions that have the potential to become biomarkers in therapeutic applications. Therefore, accurate and sensitive
Jiani Dong, Zhuoer Zeng, Ying Huang, Chuanpin Chen, Zeneng Cheng, Qubo Zhu   +5 more
semanticscholar   +1 more source

The interaction of circRNAs and RNA binding proteins: An important part of circRNA maintenance and function

Journal of Neuroscience Research, 2020
The widespread expression of circular RNAs (circRNAs) is regarded as a feature of gene expression in highly diverged eukaryotes. Recent studies have shown that circRNAs can act as a miRNA sponge to repress miRNA function, participate in splicing of ...
Jiankun Zang, Dan Lu, Anding Xu
semanticscholar   +1 more source

CircRNAs in diabetic cardiomyopathy

Clinica Chimica Acta, 2021
Diabetic cardiomyopathy is an important irreversible chronic cardiovascular complication in diabetic patients. This condition is described as early diastolic dysfunction, myocardial fibrosis, cardiac hypertrophy, systolic dysfunction and other complex pathophysiological events, which ultimately lead to heart failure.
Hengquan Wan, Simin Zhao, Qian Zeng, Yao Tan, Chi Zhang, Lingyun Liu, Shunlin Qu   +6 more
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Collaborative deep learning improves disease-related circRNA prediction based on multi-source functional information

Briefings Bioinform., 2023
Emerging studies have shown that circular RNAs (circRNAs) are involved in a variety of biological processes and play a key role in disease diagnosing, treating and inferring. Although many methods, including traditional machine learning and deep learning,
Yongtian Wang, Xinmeng Liu, Yewei Shen, Xuerui Song, Tao Wang, Xuequn Shang, Jiajie Peng   +6 more
semanticscholar   +1 more source

circRNA: a promising all-around star in the future.

Epigenomics, 2023
circRNA is a type of RNA molecule with a circular structure. From initially thinking it was useless to now discovering that it has important and complex functions, the importance of circRNA is increasingly being recognized.
Hanling Li
semanticscholar   +1 more source

CircRNA–miRNA interactions in atherogenesis

Molecular and Cellular Biochemistry, 2022
Atherosclerosis is the major cause of coronary artery disease (CAD) which includes unstable angina, myocardial infarction, and heart failure. The onset of atherogenesis, a process of atherosclerotic lesion formation in the intima of arteries, is driven by lipid accumulation, a vicious cycle of reactive oxygen species (ROS)-induced oxidative stress and ...
Kind-Leng Tong, Ke-En Tan, Yat-Yuen Lim, Xin-Yi Tien, Pooi-Fong Wong   +4 more
openaire   +3 more sources

CircRNAs in Plants

2018
Circular RNAs (circRNAs) are covalently closed, single-stranded transcripts that are ubiquitously expressed in all eukaryotes and even prokaryotic archaea. Although once regarded as splicing artifacts, circRNAs are a novel class of regulatory molecules with diverse biological functions, including regulation of transcription, modulation of alternative ...
Lai, Xuelei, Bazin, Jérémie, Webb, Stuart, Crespi, Martin, Zubieta, Chloe, Conn, Simon   +5 more
openaire   +4 more sources

circRNA and gastrointestinal cancer

Journal of Cellular Biochemistry, 2019
AbstractCircular RNAs (circRNAs) are a novel class of endogenous noncoding RNAs that form covalently closed continuous loops without 3′ end poly (A) tails and 5′ end caps. circRNAs are more conservative and stable than linear RNA. circRNAs can specifically bind to microRNAs as competing endogenous RNA, thereby directly or indirectly regulating the ...
Bing Luo, Chao‐ming Tang, Jing‐Song Chen   +2 more
openaire   +2 more sources

CircRNA as an Achilles heel of cancer: characterization, biomarker and therapeutic modalities

Journal of Translational Medicine
Circular RNAs (circRNAs) are a class of endogenous noncoding RNAs characterized by their lack of 5′ caps and 3′ poly(A) tails. These molecules have garnered substantial attention from the scientific community. A wide range of circRNA types has been found
Jun Zhang, Zai Luo, Yang Zheng, Mingyu Duan, Zheng-Jun Qiu, Chen Huang   +5 more
semanticscholar   +1 more source

CRISPR–Cas13 targets circRNAs

Nature Reviews Genetics, 2020
The CRISPR–Cas13 system can be used to knock down circular RNAs (circRNAs) without any impact on related mRNAs, reports a study in Nature Methods.
openaire   +2 more sources