Results 311 to 320 of about 52,173 (326)

CircRNAs and LncRNAs in Osteoporosis

Differentiation, 2020
Osteoporosis is a systemic bone disease with bone fragility and increased fracture risk. The non-coding RNAs (ncRNAs) have appeared as important regulators of cellular signaling and pertinent human diseases. Studies have demonstrated that circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs) are involved in the progression of osteoporosis through
Tiantian He, Wei Liu, Lihua Cao, Ying Liu, Zi Zou, Yancheng Zhong, Haihua Wang, Yuqing Mo, Shuping Peng, Cijun Shuai   +9 more
openaire   +2 more sources

A machine learning framework based on multi-source feature fusion for circRNA-disease association prediction

Briefings Bioinform., 2022
Circular RNAs (circRNAs) are involved in the regulatory mechanisms of multiple complex diseases, and the identification of their associations is critical to the diagnosis and treatment of diseases.
Lei Wang, Leon Wong, Zhengwei Li, Yuan Huang, Xiao-Rui Su, Bowei Zhao, Zhuhong You   +6 more
semanticscholar   +1 more source

CircRNA-mediated ceRNA mechanism in Osteoarthritis: Special emphasis on circRNAs in exosomes and the crosstalk of circRNAs and RNA methylation

Biochemical Pharmacology, 2023
Osteoarthritis (OA) is an age-related joint disease with chronic inflammation, progressive articular cartilage destruction and subchondral bone sclerosis. CircRNAs (circRNAs) are a class of non-coding RNA with a circular structure that participate in a series of important pathophysiological processes of OA, especially its ceRNA mechanisms, and play an ...
Qiuyun, Xue, Yurong, Huang, Jun, Chang, Chenglong, Cheng, Yuting, Wang, Xiaomei, Wang, Chenggui, Miao   +6 more
openaire   +2 more sources

Circular RNAs (circRNAs) in cancer

Cancer Letters, 2018
Circular RNAs (circRNAs) are a class of non-coding RNAs that do not have 5' end caps or 3' end poly (A) tails. There are more than one hundred thousand genes that encode circRNAs. Clinical data show that there are differences in the expression of circRNAs in a variety of diseases, including cancer, suggesting that circRNA has a regulatory effect on ...
Ruoyu Zhou, Yuwei Wu, Wenxi Wang, Wenjia Su, Yicong Liu, Yumin Wang, Chunmei Fan, Xiaoling Li, Guiyuan Li, Yong Li, Wei Xiong, Zhaoyang Zeng   +11 more
openaire   +2 more sources

Structure-Mediated Degradation of CircRNAs

Trends in Cell Biology, 2020
The elaborate control of biogenesis and turnover is essential for circular RNAs (circRNAs) to exert their functions properly in eukaryotic cells, whereas how circRNAs are degraded remains unclear. A recent study by Fischer et al. reveals a novel structure-mediated circRNA decay that selectively degrades highly structured RNAs by UPF1 and G3BP1.
Yingli, Guo, Xiawei, Wei, Yong, Peng
openaire   +2 more sources

Nonradioactive Northern Blot of circRNAs

2018
Circular RNAs (circRNAs) are recognized as a special species of transcripts in metazoans with increasing studies, and northern blotting is a direct way to confirm the existence and to evaluate the size of individual circRNAs. Northern blotting probes can be radioactive isotope (32P) labeled, which is not environment-friendly and sometimes inconvenient ...
Xiaolin, Wang, Ge, Shan
openaire   +2 more sources

CircRNA regulates lung cancer metastasis

Gene
Lung cancer stands prominently among the foremost contributors to human mortality, distinguished by its elevated fatality rate and the second-highest incidence rate among malignancies. The metastatic dissemination of lung cancer stands as a primary determinant of its elevated mortality and recurrence rates, underscoring the imperative for comprehensive
Han, Li, Fan, Wu, Yaqi, Han, Ziyi, Guo, Tangbing, Chen, Zhongliang, Ma   +5 more
openaire   +2 more sources

CircRNA in cancer: Fundamental mechanism and clinical potential.

Cancer Letters, 2021
Liang Chen, G. Shan
semanticscholar   +1 more source

CircRNAs in cancer therapy tolerance

Clinica Chimica Acta
The rapidly expanding field of circular RNA (circ-RNA) research has opened new avenues in cancer diagnostics and treatment, highlighting the role of serum circRNAs as potential biomarkers for assessing tumor therapy resistance. This review comprehensively compiles existing knowledge regarding the biogenesis, function, and clinical relevance of circRNAs,
Miao He, Yunyan Pan, Chongge You, Hongwei Gao   +3 more
openaire   +2 more sources

circRNA biogenesis competes with pre-mRNA splicing.

Molecules and Cells, 2014
Reut Ashwal-Fluss, M. Meyer, N. Pamudurti, Andranik Ivanov, Osnat Bartok, M. Hanan, Naveh Evantal, Sebastian Memczak, N. Rajewsky, S. Kadener   +9 more
semanticscholar   +1 more source