Results 1 to 10 of about 597,183 (144)

Bioinformatic prospecting and phylogenetic analysis reveals 94 undescribed circular bacteriocins and key motifs [PDF]

BMC Microbiology, 2020
Background Circular bacteriocins are antimicrobial peptides produced by bacteria with a N and C termini ligation. They have desirable properties such as activity at low concentrations along with thermal, pH and proteolytic resistance.
Ben Vezina, Bernd H. A. Rehm, Andrew T. Smith   +2 more
doaj   +5 more sources

In Silico Analysis Highlights the Diversity and Novelty of Circular Bacteriocins in Sequenced Microbial Genomes [PDF]

mSystems, 2020
Consumer demand for “fresh food” with no chemical preservatives has prompted researchers to pay more attention to natural antimicrobial peptides such as bacteriocins.
Bingyue Xin, Hualin Liu, Jinshui Zheng, Chuanshuai Xie, Ying Gao, Dadong Dai, Donghai Peng, Lifang Ruan, Huanchun Chen, Ming Sun   +9 more
doaj   +5 more sources

In vitro and in vivo production and split-intein mediated ligation (SIML) of circular bacteriocins [PDF]

Frontiers in Microbiology, 2022
Circular bacteriocins are antimicrobial peptides produced by bacteria that after synthesis undergo a head-to-tail circularization. Compared to their linear counterparts, circular bacteriocins are, in general, very stable to temperature and pH changes and
Nuria Peña, Michael J. Bland, Ester Sevillano, Estefanía Muñoz-Atienza, Irene Lafuente, Mohamed El Bakkoury, Luis M. Cintas, Pablo E. Hernández, Philippe Gabant, Juan Borrero   +9 more
doaj   +3 more sources

Split Intein-Mediated Engineering of Bacteriocins Through Backbone Circularization, Modular Assembly of Chimeras, and Inducible Circularization [PDF]

Biomolecules
The increasing prevalence of antimicrobial resistance has renewed interest in bacteriocins and other antimicrobial peptides as promising alternatives to conventional antibiotics.
Irene Lafuente, Ester Sevillano, Nuria Peña, Cleopatra Collado, Luis M. Cintas, Pablo E. Hernández, Estefanía Muñoz-Atienza, Juan Borrero   +7 more
doaj   +2 more sources

Engineering circular bacteriocins: structural and functional effects of α-helix exchanges and disulfide introductions in circularin A [PDF]

Frontiers in Microbiology
Circular bacteriocins form a distinct group of antimicrobial peptides (AMPs) characterized by their unique head-to-tail ligated circular structure and functional properties.
Fangfang Liu, Auke J. van Heel, Auke J. van Heel, Oscar P. Kuipers, Oscar P. Kuipers   +4 more
doaj   +2 more sources

Identification and characterization of pumicyclin A, a novel circular bacteriocin from Bacillus pumilus with a dispensable leader peptide [PDF]

mBio
Foodborne pathogens such as Listeria monocytogenes and Bacillus cereus continue to pose serious threats to global food safety, driving demand for natural, consumer-friendly preservation strategies.
Fangfang Liu, Xiaohui Huang, Paula M. O’Connor, Felipe Miceli de Farias, Colin Buttimer, Colin Hill, Oscar P. Kuipers, R. Paul Ross   +7 more
doaj   +2 more sources

Transporter Protein-Guided Genome Mining for Head-to-Tail Cyclized Bacteriocins

Molecules, 2021
Head-to-tail cyclized bacteriocins are ribosomally synthesized antimicrobial peptides that are defined by peptide backbone cyclization involving the N- and C- terminal amino acids.
Daniel Major, Lara Flanzbaum, Leah Lussier, Carly Davies, Kristian Mark P. Caldo, Jeella Z. Acedo   +5 more
doaj   +3 more sources

The Hungate1000 prokaryotic culture collection encodes a wide variety of bacteriocins [PDF]

mSystems
Bacteriocins are antimicrobial peptides/proteins that are widely distributed among bacteria and are gathering traction as natural alternatives to antibiotics, modulators of the microbiota, and interbacterial signaling peptides.
David Hourigan, Lorraine Draper, Sinead C. Leahy, Graeme T. Attwood, William J. Kelly, Catherine Stanton, Colin Hill, R. Paul Ross   +7 more
doaj   +2 more sources

Multiplexed bacteriocin synthesis to combat and prevent antimicrobial resistance [PDF]

Communications Biology
Bacteriocins are underexplored yet promising candidates to combat antimicrobial resistance (AMR) and enable targeted therapy due to their natural origin, abundance and narrow spectrum of activity.
Alex Quintero-Yanes, Kenny Petit, Hector Rodriguez-Villalobos, Hanne Vande Capelle, Olivier De Veirman, Hans Gerstmans, Joleen Masschelein, Juan Borrero, Pascal Hols, Philippe Gabant   +9 more
doaj   +2 more sources

Characterization of Flexusin A, a Novel Circular Bacteriocin Produced by Marine Bacterium Bacillus flexus R29-2 [PDF]

Marine Drugs
Circular bacteriocins are potent antimicrobials against pathogenic Gram-positives. In searching for marine bacteriocins, an antibacterial peptide (flexusin A) was purified from the fermentation broth of marine bacterium Bacillus flexus R29-2.
Xiaoni Qiao, Xiaowen Sun, Shuting Wang, Chen Zhai, Wei Tang, Tao Tang, Jun Zhang, Zengguo He   +7 more
doaj   +2 more sources