Results 91 to 100 of about 152,468 (288)

Indole alkaloid sulfonic acids from an aqueous extract of Isatis indigotica roots and their antiviral activity

Acta Pharmaceutica Sinica B, 2017
Six new indole alkaloid sulfonic acids (1–6), together with two analogues (7 and 8) that were previously reported as synthetic products, were isolated from an aqueous extract of the Isatis indigotica root.
Lingjie Meng, Qinglan Guo, Yufeng Liu, Minghua Chen, Yuhuan Li, Jiandong Jiang, Jiangong Shi   +6 more
doaj   +1 more source

Visualization of Endosomal Escape of Intracellularly Delivered Protein With Unexpected Photochemical Internalization of Trypan Blue

Advanced Science, EarlyView.
TB, a conventional cell viability dye, acts as both a fluorescence modulator (quenching GFP fluorescence upon protein binding and recovering it upon release) and a photosensitizer that triggers endosomal escape via photochemical internalization (PCI) under 590 nm light.
Zhongqi Yao, Zhan Shi, Peng Hu, Changping Wang, Hui Wang   +4 more
wiley   +1 more source

Tunable chiral and nematic states in the triple-Q antiferromagnet Co1/3TaS2

Nature Communications
Complex spin configurations in magnetic materials, ranging from collinear single-Q to non-coplanar multi-Q states, exhibit rich symmetry and chiral properties.
Erik Kirstein, Pyeongjae Park, Woonghee Cho, Cristian D. Batista, Je-Geun Park, Scott A. Crooker   +5 more
doaj   +1 more source

Circular Dichroism Reflectance Anisotropy of Chiral Atomically Thin Films

Chemosensors
Recently, a technical modification of a Reflectance Anisotropy Spectroscopy (RAS) spectrometer has been proposed to investigate the circular dichroism (CD) of samples instead of the normally studied linear dichroism. CD-RAS measures the anisotropy of the
Ilaria Tomei, Filippo Pierucci, Beatrice Bonanni, Anna Sgarlata, Massimo Fanfoni, Seong-Jun Yang, Cheol-Joo Kim, Claudio Goletti   +7 more
doaj   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

The AUTACE That Degrades KRAS and Engages CD8+ T Cells for the Treatment of KRAS/TP53 Co‐Mutant Tumors

Advanced Science, EarlyView.
AUTACE is a bifunctional nanoplatform that integrates tumor targeting, immune engagement, and on‐demand KRAS degradation. It targets KRAS/TP53 co‐mutant tumors via TP53‐specific TCRs, elicits antitumor CD8+ T‐cell responses through surface anti‐CD3 antibodies, and uses low‐intensity focused ultrasound (LIFU) to trigger controlled release of the KRAS ...
Luo Li, Bolin Li, Yanan Hao, Bo Pang, Pan Li, Chunli Li, Yu Tang   +6 more
wiley   +1 more source

Chiroptical and Magneto‐Optical Properties of Chiral Copper Phthalocyanine‐Based Thin Films

ChemistryEurope
Chirality, once considered unrelated to magnetism, has recently been recognized to couple with magnetic fields through magneto‐chiral anisotropies (MChAs), such as magneto‐chiral dichroism (MChD).
Kazuyuki Ishii, Keishi Yamaguchi, Ryo Ishii, Kei Murata   +3 more
doaj   +1 more source

Investigation on the Recognition of Split Aflatoxin M1 Aptamer

Shipin gongye ke-ji
In this work, AFM1 was chosen as the target, and the aptamer was split to solve the low sensitivity due to unstable structure of the aptamer. The recognition ability and specificity of the split aptamer were evaluated using electrochemical methods, and ...
Yekun ZHENG, Congcong DU, Honglin LI, Ting GUO, Yuhao ZHANG, Liang MA   +5 more
doaj   +1 more source

Giant Circular Dichroism in Individual Carbon Nanotubes Induced by Extrinsic Chirality

Physical Review X, 2014
Circular dichroism is widely used for characterizing organic and biological materials, but measurements at a single-molecule level are challenging because differences in absorption for opposite helicities are small. Here, we show that extrinsic chirality
A. Yokoyama, M. Yoshida, A. Ishii, Y. K. Kato   +3 more
doaj   +1 more source

Electronic circular dichroism behavior of chiral Phthiobuzone

Acta Pharmaceutica Sinica B, 2014
Phthiobuzone is a bis(thiosemicarbazone) derivative with a single chiral center which has been used as a racemate in the clinical treatment of herpes and trachoma diseases.
Li Li, Lin Wang, Yikang Si
doaj   +1 more source