Results 111 to 120 of about 653,628 (283)

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

Electronic circular dichroism behavior of chiral Phthiobuzone

Acta Pharmaceutica Sinica B, 2014
Phthiobuzone is a bis(thiosemicarbazone) derivative with a single chiral center which has been used as a racemate in the clinical treatment of herpes and trachoma diseases.
Li Li, Lin Wang, Yikang Si
doaj   +1 more source

Self-organising amphiphilic oligothiophene block co-polymers [PDF]

, 1999
A new route to oligothiophene-PEO-block-co-polymers has been developed, in which well-defined a-oligothiophene blocks (from bithiophene to sexithiophene) alternate with poly(ethylene oxide) blocks.
Kilbinger, Andreas Felix Michael
core  

Local Solvent Ordering Drives Supramolecular Chirality Inversion

Advanced Science, EarlyView.
Local solvent organization is shown to govern supramolecular chirality by selecting distinct chiral assembly pathways. A subtle change in water‐DMSO composition reverses the helical sense of a chiral perylene bisimide, while heating induces an irreversible thermal inversion to a more stable enantiomorph.
Triza Pal, Akta Singh, Subinoy Adhikari, Jagannath Mondal, Debangshu Chaudhuri   +4 more
wiley   +1 more source

Valley-selective circular dichroism of monolayer molybdenum disulphide

, 2012
A two-dimensional honeycomb lattice harbours a pair of inequivalent valleys in the k-space electronic structure, in the vicinities of the vertices of a hexagonal Brillouin zone, K-+/-.
Wang, Enge, Liu, Baoli, Gang,W,Han,WP, Wang, Gang, Han, Wenpeng, Zhu, C, Shi, J, Wang, E, Cao, T, Wang, G, Zhu, Chuanrui, Shi, Junren, Tan, P, Ye,HQ, Tan, Pingheng, Han, W, ,, Ye, Huiqi, Niu, Q, Feng, J, Ting,C, Feng, Ji, Liu, B, Ye, H, Cao, Ting, Niu, Qian   +25 more
core   +1 more source

Symmetry‐Imposed Selection Rules for Excitations of Nontrivial Plasmonic Topologies

Advanced Science, EarlyView.
A unified group‐theory selection rule governs the excitation of vectorial nearfield topologies across three plasmonic spin states. Derived from first principles, it predicts spin–orbit vortex splitting and multidimensional nested vortices, confirmed by phase‐resolved in situ measurements.
Jie Yang, Pengyi Feng, Fei Han, Weijin Chen, Zhongwei Jin, Jincheng Ni, Yuanjie Yang, Anxue Zhang, Guy A. E. Vandenbosch, Niels Verellen, Ewald Janssens, Jiafu Wang, Benfeng Bai, Cheng‐Wei Qiu, Xuezhi Zheng   +14 more
wiley   +1 more source

Multidimensional helical dichroism from a chiral molecular nanoassembly

Nature Communications
Detecting the chirality of molecules is of great importance in optics, biomedicine, and materials science. In chiroptical spectroscopy, it’s crucial to achieve strong chiroptical signals with a minimal number of chiral molecules.
Yusheng Jin, Xinghao Wang, Zhijie Xia, Xiaoxu Rao, Xiaomei Chen, Kaixuan Li, Yucheng Jiang, Jiaru Chu, Dong Wu, Cheng-Wei Qiu, Jincheng Ni   +10 more
doaj   +1 more source

Cobalt‐Catalyzed Asymmetric Construction of Boron Stereocenters With C–N Axial Chirality

Advanced Science, EarlyView.
A cobalt/Salox‐catalyzed one‐pot annulation enables enantioselective formation of B‐stereogenic centers and C─N axial chirality via C─H/N─H annulation, affording diverse fluorescent products with high stereocontrol and optoelectronic potential. ABSTRACT The efficient construction of boron stereogenic centers alongside axial chirality remains a ...
Subramani Kumaran, Harihara Subramanian Ravi Sankar, Pritam Maity, J. Richard Premkumar, Abir Das, Basker Sundararaju   +5 more
wiley   +1 more source

Nanoscale Confinement Enhances Ultrafast Demagnetization

Advanced Science, EarlyView.
Next generation spintronics may depend on successfully combining femtosecond spin dynamics with nanoscale device miniaturization. We address this by systematically studying the effect of nanoscale confinement on the femtosecond demagnetization of Iron. By combining ultrafast experiments sensitive to spins, charge carriers, and phonons, we uncover a nm ...
Yoav William Windsor, Tobias Lojewski, Moumita Kundu, Klaus Sokolowski‐Tinten, Nico Rothenbach, Andrea Eschenlohr, Markus Ernst Gruner, Katharina Ollefs, Carolin Schmitz‐Antoniak, Soma Salamon, Daniela Zahn, Laurenz Rettig, Christian Schüßler‐Langeheine, Niko Pontius, Renkai Li, Mianzhen Mo, Suji Park, Xiaoshe Shen, Stephen Weathersby, Xijie Wang, Rossitza Pentcheva, Heiko Wende, Ulrich Nowak, Uwe Bovensiepen   +23 more
wiley   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source