Results 51 to 60 of about 1,797,821 (330)
Circular RNAs in the tumour microenvironment [PDF]
Molecular Cancer, 2020 AbstractBackgroundCircular RNAs (circRNAs) are a new class of endogenous non-coding RNAs (ncRNAs) widely expressed in eukaryotic cells. Mounting evidence has highlighted circRNAs as critical regulators of various tumours. More importantly, circRNAs have been revealed to recruit and reprogram key components involved in the tumour microenvironment (TME),
Zhonghua Ma +4 more
openaire +4 more sources
Experimental and Molecular Medicine, 2018 Spinal disease: Circular RNA linked to disc degeneration A circular RNA molecule helps protect against degenerative disc disease. Hua Wang and coworkers from Sun Yat-Sen University in Guangzhou, China, examined whether circular RNAs, regulatory molecules
Hua Wang +8 more
doaj +1 more source
CiLiQuant: Quantification of RNA Junction Reads Based on Their Circular or Linear Transcript Origin
Frontiers in Bioinformatics, 2022 Distinguishing circular RNA reads from reads derived from the linear host transcript is a challenging task because of sequence overlap. We developed a computational approach, CiLiQuant, that determines the relative circular and linear abundance of ...
Annelien Morlion +13 more
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Circular Ribonucleic Acid Expression in Patient with Acne [PDF]
Egyptian Journal of Medical Research, 2022 Background: Acne is a common chronic skin disease with a multifactorial aetiology and pathogenesis. Recently, circular RNAs (circRNAs) have been identified as a key factor in regulating gene expression through circRNA–miRNA–mRNA networks in many ...
Abd-Elaziz El-Taweel +3 more
doaj +1 more source
, 2018 Recent advances in RNA sequencing and bioinformatic analysis have allowed the development of a new research field: circular RNAs (circRNAs). These members of the non-coding transcriptome are generated by backsplicing, which results in a covalently closed, single-stranded RNA molecule.
Vicenta Llorente-Cortés +2 more
openaire +4 more sources
Characterizing Expression and Regulation of Gamma-Herpesviral Circular RNAs
Frontiers in Microbiology, 2021 Multiple herpesviruses have been recently found to encode viral circular RNAs. Like cellular circular RNAs, these RNAs lack poly-A tails and their 5′ and 3′ ends have been joined, which confers protection from RNA exonucleases. We examined the expression
Takanobu Tagawa +10 more
doaj +1 more source
Circular RNA cancer vaccines drive immunity in hard-to-treat malignancies
Theranostics, 2022 Rationale: Messenger RNA (mRNA) vaccine outperforms other kinds of cancer immunotherapy due to its high response rates, easy preparation, and wide applicability, which is considered as one of the most promising forms of next-generation cancer therapies ...
Hongjian Li +8 more
semanticscholar +1 more source
Circular RNAs in Blood Malignancies [PDF]
Frontiers in Molecular Biosciences, 2020 Circular (circ)RNAs influence a wide range of biological processes at least in part by interacting with proteins and microRNAs. CircRNAs expressed in the hematopoietic compartment have been increasingly recognized as modulators of physiological and pathological features of hematopoetic stem cell (HSC)-derived populations.
Martina Rossi +2 more
openaire +3 more sources
Cell Transplantation, 2019 Emerging evidence demonstrates that dysregulation of circular RNA is linked to tumorigenesis and aggressive progression. However, its role in oral squamous cell carcinoma remains largely uncharacterized.
Bing Xia +4 more
doaj +1 more source
Cost-Effective Transcriptome-Wide Profiling of Circular RNAs by the Improved-tdMDA-NGS Method
Frontiers in Molecular Biosciences, 2022 Covalently closed circular RNAs are neoteric to the eukaryotic family of long non-coding RNAs emerging as a result of 5′–3′ backsplicing from exonic, intronic, or intergenic regions spanning the parental gene.
Ashirbad Guria +5 more
doaj +1 more source