Results 301 to 310 of about 2,013,218 (333)

An Overview of Circular RNAs

2018
Circular RNAs (cirRNAs) are long, noncoding endogenous RNA molecules and covalently closed continuous loop without 5'-3' polarity and polyadenylated tail which are largely concentrated in the nucleus. CirRNA regulates gene expression by modulating microRNAs and functions as potential biomarker.
Awasthi, Rajendra, Singh, Anurag Kumar, Mishra, Gaurav, Maurya, Anand, Chellappan, Dinesh Kumar, Gupta, Gaurav, Hansbro, Philip Michael, Dua, Kamal   +7 more
openaire   +2 more sources

Circular RNA in cancer

Nature Reviews Cancer
Over the past decade, circular RNA (circRNA) research has evolved into a bona fide research field shedding light on the functional consequence of this unique family of RNA molecules in cancer. Although the method of formation and the abundance of circRNAs can differ from their cognate linear mRNA, the spectrum of interacting partners and their ...
Vanessa M. Conn, Arul M. Chinnaiyan, Simon J. Conn   +2 more
openaire   +2 more sources

An Overview of Circular RNAs

Circular RNAs (circRNAs) are a class of endogenous, covalently closed RNA molecules. Unlike linear RNAs, circRNAs are formed through noncanonical splicing, during which a downstream donor site is ligated with an upstream splice acceptor site, building a backsplice junction (BSJ), the distinguishing feature of circRNAs.
Julia, Mester-Tonczar, Ena, Hasimbegovic
openaire   +2 more sources

Formation of Circular RNAs

Circular RNAs (circRNAs) constitute a class of covalently closed, single-stranded RNA molecules that form a continuous loop structure, setting them apart from linear RNA molecules. These circular entities arise through a distinct biogenetic process termed "backsplicing," which involves the covalent bonding of the 5' site of an upstream exon with the 3'
Arvind, Srinivasan, Marzena, Wojciechowska   +1 more
openaire   +2 more sources

Circular RNA

Nature Biotechnology, 2021
openaire   +2 more sources

Circular RNAs and Neuronal Development

2018
Circular RNAs (circRNAs) are abundant in the brain and are often expressed in complex spatiotemporal patterns that coincide with distinct developmental transitions. This suggests that circRNAs play a significant role in the central nervous system. This book chapter will review research progress into the function of circRNAs during neuronal development.
openaire   +5 more sources

Circular RNAs in Metabolic Diseases

2018
Metabolic diseases include diabetes mellitus (DM), obesity, metabolic syndrome, and non-alcoholic fatty liver disease (NAFLD). Circular RNA is a new type of RNA that is different from traditional linear RNA and has a closed loop structure. However, the function of circular RNA is not yet well elucidated in metabolic diseases.
Tianhui, Wang, Wen, Pan, Jun, Hu, Zhongrong, Zhang, Guoping, Li, Yajun, Liang   +5 more
openaire   +2 more sources

The biogenesis, biology and characterization of circular RNAs

Nature reviews genetics, 2019
L. Kristensen, M. S. Andersen, L. V. W. Stagsted, K. K. Ebbesen, T. B. Hansen, J. Kjems   +5 more
semanticscholar   +1 more source

Characterization of Circular RNA Concatemers

2018
Circular RNAs (circRNAs) constitute a novel subset in the fascinating world of noncoding RNA, and they are found in practically all eukaryotes. Most of them exhibit low expression levels but some are extremely abundant. Typically, circRNAs are studied by RT-PCR-based assays, but for certain types of analyses this technique is not suitable. Circular RNA
openaire   +2 more sources

Exon-intron circular RNAs regulate transcription in the nucleus

Nature Structural &Molecular Biology, 2015
Zhaoyong Li, Chuan Huang, Chun Bao, Liang Chen, Mei Lin, Xiaolin Wang, Guolin Zhong, Bin Yu, Wanchen Hu, Limin Dai, Pengfei Zhu, Zhaoxia Chang, Qingfa Wu, Yi Zhao, Y. Jia, Ping Xu, Huijie Liu, G. Shan   +17 more
semanticscholar   +1 more source