Results 291 to 300 of about 2,013,218 (333)

Circular RNA Splicing

2018
Circular RNAs (circRNAs) are covalently closed single-stranded RNA molecules derived from exons by alternative mRNA splicing. Circularization of single-stranded RNA molecules was already described in 1976 for viroids in plants. Since then several additional types of circular RNAs in many species have been described such as the circular single-stranded ...
Nicole, Eger, Laura, Schoppe, Susanne, Schuster, Ulrich, Laufs, Jes-Niels, Boeckel   +4 more
openaire   +2 more sources

Exosomal circular RNAs: A chief culprit in cancer chemotherapy resistance.

Drug resistance updates, 2023
Chemotherapy is one of the primary treatments for malignant tumors. However, the acquired drug resistance hinders clinical efficacy and leads to treatment failure in most patients.
Xueting Guo, Congying Gao, Dong-Hua Yang, Shenglong Li   +3 more
semanticscholar   +1 more source

Circular RNAs and cancer

Cancer Letters, 2017
Circular RNAs (circRNAs) are a type of non-coding RNA molecules that lack a 5'-terminal cap and 3'-terminal poly A tail. A large number of circRNAs have been identified through biological experiments, computational methods and high-throughput sequencing. CircRNA sequence composition determines if a given circRNA is exonic, intronic or retained-intronic.
Jun He, Qichao Xie, Hailin Xu, Jiantian Li, Yongsheng Li   +4 more
openaire   +2 more sources

Small circular RNAs as vaccines for cancer immunotherapy

Nature Biomedical Engineering
Messenger RNA vaccines have shown strong prophylactic efficacy against viral infections. Here we show that antigen-encoding small circular RNAs (circRNAs) loaded in lipid nanoparticles elicit potent and durable T cell responses for robust tumour ...
Yu Zhang, Xiang Liu, Tingting Shen, Qiyan Wang, Shurong Zhou, Suling Yang, Shimiao Liao, Ting Su, Lei Mei, Bei Zhang, Khoa L. A. Huynh, Linying Xie, Youzhong Guo, Chunqing Guo, K. Tyc, Xufeng Qu, Xiang-Yang Wang, Jinze Liu, Guizhi Zhu   +18 more
semanticscholar   +1 more source

Role of circular RNAs in retinoblastoma

Functional & Integrative Genomics, 2022
Retinoblastoma (RB), the most common malignant retinal tumor among children under 3 years old, is lethal if left untreated. Early diagnosis, together with timely and effective treatment, is important to improve retinoblastoma-related outcomes. Circular RNAs (circRNAs), a new class of non-coding RNAs with the capacity to regulate cellular activities ...
Fei, Li, Yi-Ke, Yin, Ji-Tao, Zhang, Hai-Pai, Gong, Xiao-Dan, Hao   +4 more
openaire   +2 more sources

Circular RNAs in Cancer: Biogenesis, Function, and Clinical Significance.

Trends in Cancer, 2020
Circular RNA (circRNA) is a class of single-stranded molecules with tissue/development-specific expression patterns. Unlike linear RNA, circRNA forms a covalently closed loop produced from 'back-splicing' of primary transcripts, conferring on them ...
Jiao Li, Dan Sun, Wenchen Pu, Jin Wang, Yong Peng   +4 more
semanticscholar   +1 more source

Circular RNAs in glioblastoma

Clinica Chimica Acta
Glioblastoma multiforme (GBM) is the most malignant and common form of brain cancer in adults. The molecular mechanisms underlying GBM progression and resistance are complex and poorly understood. Circular RNAs (circRNAs) are a new class of non-coding RNAsformed by covalently closed loopstructures with no free ends.
Elham, Ghadami, Mahjoobeh, Jafari, Masoumeh, Razipour, Mohaddese, Maghsudlu, Mohsen, Ghadami   +4 more
openaire   +2 more sources

Circular RNAs and Cancers

Circular RNAs (circRNAs) are a recently discovered type of endogenous RNA molecules that are formed through the back-splicing process of exons in precursor messenger RNAs (pre-mRNAs), resulting in a unique covalently closed circular structure. CircRNAs are just beginning to be acknowledged for their roles as microRNA sponges and protein scaffolds ...
Mohammad Mahdi, Heidari, Mohammad Saeid, Moeinfar, Mahdi, Rafiyan, Parsa, Sepehri, Ameneh, Jafari, Arash, Raisi, Fatemeh, Aslanbeigi, Ashkan, Bahrami, Maryam Nasr, Azadani, Neda, Rahimian, Maryam, Mahjoubin-Tehran, Hamed, Mirzaei   +11 more
openaire   +2 more sources

Circular RNAs: Biogenesis and Functions : Circular RNA detection and bioinformatic analysis.

Advances in Experimental Medicine and Biology
Circular RNAs (circRNAs) are noncoding RNAs (ncRNAs) that show conservation across evolutionary lines and display specific expression patterns in tissues. They perform distinctive cellular roles and are promising biomarkers in therapeutic contexts. An ever-growing area of circRNA types and biological functions is closely related to recent advancements ...
H. Vural
semanticscholar   +3 more sources

Characterization of Circular RNAs

2016
Accumulated lines of evidence have revealed that a large number of circular RNAs are produced in transcriptomes from fruit fly to mouse and human. Unlike linear RNAs shaped with 5' cap and 3' tail, circular RNAs are characterized by covalently closed loop structures without open terminals, thus required specific treatments for their identification and ...
Yang, Zhang, Li, Yang, Ling-Ling, Chen
openaire   +3 more sources