Results 41 to 50 of about 2,068,901 (353)

Label-free isolation of prostate circulating tumor cells using Vortex microfluidic technology. [PDF]

, 2017
There has been increased interest in utilizing non-invasive "liquid biopsies" to identify biomarkers for cancer prognosis and monitoring, and to isolate genetic material that can predict response to targeted therapies. Circulating tumor cells (CTCs) have
Che, James, Di Carlo, Dino, Jeffrey, Stefanie S, Kulkarni, Rajan P, Lemaire, Clementine A, Liu, Haiyan E, Matsumoto, Melissa, Pao, Edward, Renier, Corinne, Rettig, Matthew, Sollier-Christen, Elodie, Srivinas, Sandy, Triboulet, Melanie   +12 more
core   +1 more source

Circulating cell-free DNA and circulating tumor cells, the “liquid biopsies” in ovarian cancer

Journal of Ovarian Research, 2017
Limited understanding of ovarian cancer (OC) genome portrait has hindered the therapeutic advances. The serial monitoring of tumor genotypes is becoming increasingly attainable with circulating cell-free DNA (cf-DNA) and circulating tumor cells (CTCs ...
Xianliang Cheng, Lei Zhang, Yajuan Chen, Chen Qing   +3 more
doaj   +1 more source

Clinical correlates of circulating cell-free DNA tumor fraction.

PLoS ONE, 2021
BackgroundOncology applications of cell-free DNA analysis are often limited by the amount of circulating tumor DNA and the fraction of cell-free DNA derived from tumor cells in a blood sample.
Joerg Bredno, Jafi Lipson, Oliver Venn, Alexander M Aravanis, Arash Jamshidi   +4 more
doaj   +1 more source

Research progress on circulating tumor cells of hepatocellular carcinoma

Journal of Interventional Medicine, 2021
Circulating tumor cells (CTCs) are the cells released from the primary tumor and found in the peripheral blood, which can colonize and develop at a distance through blood circulation. At present, the commonly used separation and detection methods of CTCs
Chenyu Wan, Bing Zhou
doaj   +1 more source

Acquired Resistance Mutations to ALK Inhibitors Identified by Single Circulating Tumor Cell Sequencing in ALK-Rearranged Non–Small-Cell Lung Cancer

Clinical Cancer Research, 2019
Purpose: Patients with anaplastic lymphoma kinase (ALK)–rearranged non–small-cell lung cancer (NSCLC) inevitably develop resistance to ALK inhibitors. New diagnostic strategies are needed to assess resistance mechanisms and provide patients with the most
Emma Pailler, V. Faugeroux, M. Oulhen, L. Mezquita, Mélanie Laporte, A. Honoré, Y. Lécluse, Pauline Queffelec, M. Ngocamus, C. Nicotra, J. Remon, L. Lacroix, D. Planchard, L. Friboulet, B. Besse, F. Farace   +15 more
semanticscholar   +1 more source

A pilot study evaluating concordance between blood-based and patient-matched tumor molecular testing within pancreatic cancer patients participating in the Know Your Tumor (KYT) initiative [PDF]

, 2016
Recent improvements in next-generation sequencing (NGS) technology have enabled detection of biomarkers in cell-free DNA in blood and may ultimately replace invasive tissue biopsies.
Aberra, Metasebia, Bender, R. Joseph, Brody, Jonathan, Chung, Vincent, Heartwell, Craig, Hendifar, Andrew, Hoos, William A., Madhavan, Subha, Mason, Kimberly, Matrisian, Lynn M., Mikhail, Sam, Petricoin, Emanuel, III, Picozzi, Vincent, Pishvaian, Michael J., Rahib, Lola, Varieur, Katelyn   +15 more
core   +2 more sources

Cellular and molecular mediators of bone metastatic lesions [PDF]

, 2018
Bone is the preferential site of metastasis for breast and prostate tumor. Cancer cells establish a tight relationship with the host tissue, secreting factors that stimulate or inhibit bone cells, receiving signals generated from the bone remodeling ...
Battafarano, Giulia, Del Fattore, Andrea, Marampon, Francesco, Rossi, Michela   +3 more
core   +2 more sources

Non-invasive Technology Advances in Cancer—A Review of the Advances in the Liquid Biopsy for Endometrial and Ovarian Cancers

Frontiers in Digital Health, 2020
Improving cancer survival rates globally requires improvements in disease detection and monitoring, with the aim of improving early diagnosis and prediction of disease relapse. Traditional means of detecting and monitoring cancers rely largely on imaging
Mark R. Openshaw, Terri P. McVeigh
doaj   +1 more source

Bioinformatics approach to mRNA markers discovery for detection of circulating tumor cells in patients with gastrointestinal cancer [PDF]

, 2008
[Abstract] Background: Detection of tumor cells in the blood, or minimal deposits in distant organs as bone marrow, could be important to identify cancer patients at high risk of relapse or disease progression. Quantitative polymerase chain reaction (PCR)
Antón-Aparicio, Luis M., Campelo, Rosario G., Díaz Prado, Silvia, Haz, Mar, Iglesias-Díaz, Pilar, Lorenzo-Patiño, María J., Medina Villaamil, Vanessa, Reboredo, Margarita, Santamarina, Isabel, Valladares-Ayerbes, Manuel   +9 more
core   +4 more sources

A conduit to metastasis: circulating tumor cell biology

Genes & Development, 2017
This review by Micalizzi et al. discusses advances in analysis and characterization of circulating tumor cells (CTCs) from patients with cancer. It focuses on the current knowledge of CTC biology and the potential clinical implications.
D. Micalizzi, S. Maheswaran, D. Haber
semanticscholar   +1 more source