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Materials and Methods, 2017
In most solid tumors, it is distant metastases rather than the primary tumor which limit the prognosis. Distant metastases are caused by circulating tumor cells (CTCs) which actively invade the blood stream, attach to the endothelium in the target organ, invade the surrounding parenchyma, and form new tumors.
M. Magbanua, John W. Park
semanticscholar +5 more sources
In most solid tumors, it is distant metastases rather than the primary tumor which limit the prognosis. Distant metastases are caused by circulating tumor cells (CTCs) which actively invade the blood stream, attach to the endothelium in the target organ, invade the surrounding parenchyma, and form new tumors.
M. Magbanua, John W. Park
semanticscholar +5 more sources
Circulating Tumor Cells and Circulating Tumor DNA
Annual Review of Medicine, 2012Solid tumors derived from epithelial tissues (carcinomas) are responsible for 90% of all new cancers in Europe, and the main four tumor entities are breast, prostate, lung, and colon cancer. Present tumor staging is mainly based on local tumor extension, metastatic lymph node involvement, and evidence of overt distant metastasis obtained by imaging ...
Catherine, Alix-Panabières +2 more
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Circulating Tumor Cells Revisited
JAMA, 2010DESPITE THE USE OF MODERN HIGH-RESOLUTION imaging technologies, it is not possible to detect tumor cell metastasis at a single cell level. To date, cancer treatment is initiated only after the clinical presentation of disease. This approach generally is unsuccessful and translates into the dogma that metastasis is a terminal process, generally viewed ...
Massimo, Cristofanilli, Stephan, Braun
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Molecular Diagnosis & Therapy, 2012
Circulating tumor cells (CTCs) are cells of presumed epithelial origin, whose prognostic and predictive value in metastatic cancer patients has recently been demonstrated. To date, the count of CTCs through the CellSearch® system represents a valid approach for monitoring disease status in patients with metastatic colorectal, breast, and prostate ...
GAZZANIGA, PAOLA +5 more
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Circulating tumor cells (CTCs) are cells of presumed epithelial origin, whose prognostic and predictive value in metastatic cancer patients has recently been demonstrated. To date, the count of CTCs through the CellSearch® system represents a valid approach for monitoring disease status in patients with metastatic colorectal, breast, and prostate ...
GAZZANIGA, PAOLA +5 more
openaire +3 more sources
Tumor heterogeneity and circulating tumor cells
Cancer Letters, 2016In patients with cancer, individualized treatment strategies are generally guided by an analysis of molecular biomarkers. However, genetic instability allows tumor cells to lose monoclonality and acquire genetic heterogeneity, an important characteristic of tumors, during disease progression.
Chufeng Zhang +4 more
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2010
Circulating tumor cells (CTCs) can be separated and characterized from normal hematopoietic cellular constituents by a variety of methods. Different strategies have included separation by physical characteristics, such as size or weight, or by biological characteristics, such as expression of epithelial or cancer-specific markers.
Daniel F, Hayes, Jeffrey B, Smerage
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Circulating tumor cells (CTCs) can be separated and characterized from normal hematopoietic cellular constituents by a variety of methods. Different strategies have included separation by physical characteristics, such as size or weight, or by biological characteristics, such as expression of epithelial or cancer-specific markers.
Daniel F, Hayes, Jeffrey B, Smerage
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Pathology Case Reviews, 2014
Circulating tumor cells (CTCs) are tumor cells that shed from primary tumor and circulate in peripheral blood, and can be a useful clinical marker in early diagnosis and monitoring therapeutic effects for patients with malignant tumors. Detection of rare CTCs contaminated among a large number of hematologic cells presents a technical challenge, but ...
Jeanny B. Aragon-Ching +2 more
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Circulating tumor cells (CTCs) are tumor cells that shed from primary tumor and circulate in peripheral blood, and can be a useful clinical marker in early diagnosis and monitoring therapeutic effects for patients with malignant tumors. Detection of rare CTCs contaminated among a large number of hematologic cells presents a technical challenge, but ...
Jeanny B. Aragon-Ching +2 more
openaire +2 more sources