Results 81 to 90 of about 5,745,790 (267)

Targeting the CRYAB/β‐Catenin Axis with an MMP‐9‐Responsive Hydrogel Disrupts CTC Clusters to Suppress Progression of Hepatocellular Carcinoma after Radiofrequency Ablation

Advanced Science, EarlyView.
The graphical abstract illustrates that sublethal thermal stress after iRFA upregulates the chaperone CRYAB in residual HCC cells, which stabilizes β‐catenin and drives a dual pathological program, including EMT and N2‐TAN polarization, thereby leading to heterotypic CTC cluster formation. The MMP‐9‐responsive hydrogel (XB@Gel) delivers XAV‐939 and BMS‐
Hui Chen, Danni Yang, Songying Pi, Yuhan Liu, Hongbin Huang, Feile Ye, Yuhong Lin, Zhongzhen Su, Yongquan Huang   +8 more
wiley   +1 more source

Epithelial-to-mesenchymal transitions and circulating tumor cells.

, 2010
peer reviewedEpithelial-to-mesenchymal transition (EMT) phenomena endow epithelial cells with enhanced migratory and invasive potential, and as such, have been implicated in many physiological and pathological processes requiring cell migration/invasion.
Waltham, M., Thompson, Erik W., Tachsidis, Anthony, Thompson, Erik, Polette, M., Polette, Myriam, Gilles, Christine, Thompson, E. W., Tachsidis, A., Brysse, Anne, Bonnomet, Arnaud, Bonnomet, A., Waltham, Mark, Christine Gilles, Anthony Tachsidis, Erik W. Thompson, Arnaud Bonnomet, Mark Waltham, Myriam Polette, Anne Brysse   +19 more
core   +1 more source

Rapid‐Forming Conductive Antifouling Hydrogel Coating Enables Magnetically Guided Electrochemical POCT for Direct at‑Home Blood Testing

Advanced Science, EarlyView.
The SPG‐MpECis electrochemical POCT platform developed in this study enables direct detection of biomarkers in complex biological samples such as serum and fingerstick blood, demonstrating high concordance with results from clinical reference methods and holding broad potential for at‐home testing applications.
Menghan Li, Kai Su, Ruiwei Hu, Ke Gao, Yuanjie Liu, Lu Zhang, Ningke Fan, Yirong Chen, Wei Cheng, Shijia Ding, Haiping Wu   +10 more
wiley   +1 more source

Circulating tumor cells atlas – an open-access platform capturing tumor cells heterogeneity during cancer dissemination

Advances in Cancer Biology - Metastasis
Circulating tumor cells (CTCs) are key cellular intermediates in the metastatic cascade and provide a minimally invasive window into tumor heterogeneity and evolution during metastatic progression.
Anna Muchlińska, Julia Richert, Robert Wenta, Aleksandra Parteka, Marta Popęda, Beata Pieczyńska-Uziębło, Anna Żaczek, Natalia Bednarz-Knoll   +7 more
doaj   +1 more source

The presence of clustered circulating tumor cells (CTCs) and circulating cytokines define an aggressive phenotype in metastatic colorectal cancer.

, 2014
Purpose: Colon carcinoma is a malignant tumor showing a marked preference to metastasize to distant organs. The presence of circulating tumor cells (CTCs) in the peripheral blood is a prerequisite for the formation of distant metastases. However, whether
Giuliani F, Lolli I, Simone G, Abbate I, Bellizzi A, Savino E, Gadaleta Caldarola G, MAZZOCCA, ANTONIO, Divella R, Fazio V, Giannone G, SABBA', Carlo, Daniele A, Gadaleta CD   +13 more
core   +1 more source

Molecular Landscapes of Tumor Dormancy in Gynecologic Malignancies: From Survival Mechanisms to Precision Interception

Advanced Science, EarlyView.
This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng, Ren‐Wang Peng, Chang‐Cheng Wu, Chi‐Wen Luo, Emmanuel Naveen Raj, Zhi‐Hong Wen, Tzu‐Hung Hsiao, Chia‐Jung Li   +7 more
wiley   +1 more source

Circulating tumor cells as an emerging tool in cancer therapy

Frontiers in Bioscience-Landmark, 2020
Majority of the cancer-related deaths are related to metastasis during which cancer cells invade the surrounding tissues, enter (intravasation) and exit (extravasation) the peripheral circulation and seed distant organs. The Circulating Tumor Cells (CTCs)
Ajay Balakrishnan, Irene A George, Prashant Kumar   +2 more
doaj   +1 more source

Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72hi Macrophages and Blocking CXCL12–CXCR4 Axis to Inhibit Endothelial Pyroptosis

Advanced Science, EarlyView.
CD72hi macrophages drive endothelial pyroptosis and accelerate atherosclerosis through CXCL12–CXCR4‐mediated immune–vascular crosstalk. Ilexoside K suppresses this pathogenic communication by modulating CXCR4‐dependent endothelial responses, reducing inflammation and plaque progression. These findings reveal a macrophage–endothelial regulatory axis and
Xingling He, Sijing Li, Jiahui Chen, Liyu Lin, Xinyu Li, Xiaojiao Zhang, Yihui Zhang, Xingling Chen, Jinjian Guo, Zhongqi Yang, Lu Lu, Shihao Ni   +11 more
wiley   +1 more source

A multimodal single-cell framework for ecosystem-level profiling of circulating tumor and non-tumor cells

Experimental Hematology & Oncology
Multimodal profiling of circulating tumor cells (CTCs) and non-tumor circulating cells was performed in six patients with advanced colorectal cancer to identify biological programs beyond enumeration-based analyses.
Gabriela Felix, Francesca Aguirre, Lisa Zhou, Aaron Denmark, Rocio Alvarez, Daniel M. Kim, Jun Gong, Megan P. Hitchins   +7 more
doaj   +1 more source

Optically Induced Dielectrophoresis and Machine Learning Algorithms for the Identification of the Circulating Tumor Cells

Proceedings
Detecting circulating tumor cells (CTCs) is a challenge in cancer research. Their dissemination into the blood stream represents a crucial event in the formation of the metastases from the primary tumor.
Joanna Filippi, Francesca Corsi, Paola Casti, Gianni Antonelli, Michele D’Orazio, Francesco Capradossi, Rosamaria Capuano, Giorgia Curci, Lina Ghibelli, Arianna Mencattini, Eugenio Martinelli   +10 more
doaj   +1 more source