Results 121 to 130 of about 313,286 (312)

Latest Research Progress of Liquid Biopsy in Tumor—A Narrative Review

Cancer Management and Research
Hua Jiang Department of Urology, The Fifth Affiliated Hospital of Zunyi Medical University (Zhuhai Sixth People’s Hospital), Zhuhai, People’s Republic of ChinaCorrespondence: Hua Jiang, The Fifth Affiliated Hospital of Zunyi Medical University (Zhuhai ...
Jiang H
doaj  

Molecular Profiling of Circulating Tumour Cells and Circulating Tumour DNA: Complementary Insights from a Single Blood Sample Utilising the Parsortix^® System

Current Issues in Molecular Biology
The study of molecular drivers of cancer is an area of rapid growth and has led to the development of targeted treatments, significantly improving patient outcomes in many cancer types.
Gabrielle Wishart, Amy Templeman, Francesca Hendry, Karen Miller, Anne-Sophie Pailhes-Jimenez   +4 more
doaj   +1 more source

From validity to clinical utility: the influence of circulating tumor DNA on melanoma patient management in a real‐world setting

Molecular Oncology, 2018
Melanoma currently lacks a reliable blood‐based biomarker of disease activity, although circulating tumor DNA (ctDNA) may fill this role. We investigated the clinical utility (i.e., impact on clinical outcomes and interpretation of radiographic data) of ...
Steven P. Rowe, Brandon Luber, Monique Makell, Patricia Brothers, JoAnn Santmyer, Megan D. Schollenberger, Hannah Quinn, Daniel L. Edelstein, Frederick S. Jones, Karen B. Bleich, William H. Sharfman, Evan J. Lipson   +11 more
doaj   +1 more source

Detectability of Plasma-Derived Circulating Tumor DNA Panel in Patients Undergoing Primary Treatment for Uveal Melanoma

, 2022
Jasmine H. Francis, Christopher A. Barker, A. Rose Brannon, Julia Canestraro, Melissa A. Robbins, Christina E. Swartzwelder, Sara Levine, Crystal W. Law, Michael F. Berger, Alexander N. Shoushtari, David H. Abramson   +10 more
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Clinical applications of cerebrospinal fluid liquid biopsies in central nervous system tumors

Translational Oncology
For patients with central nervous system (CNS) malignancies, liquid biopsies of the cerebrospinal fluid (CSF) may offer an unparalleled source of information about the tumor, with much less risk than traditional biopsies. Two techniques have been adapted
Maria Diaz, Sofia Chudsky, Elena Pentsova, Alexandra M. Miller   +3 more
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Circulating Tumor DNA as a Marker for Treatment Response in Metastatic Melanoma Patients Using Next-Generation Sequencing—A Prospective Feasibility Study [PDF]

, 2021
B.M. Berger, Andrea Thueringer, Doritt Franz, Nadia Dandachi, Emina Talakić, Georg Richtig, Erika Richtig, Peter Michael Rohrer, Lukas Koch, Ingrid Wolf, Catharina Koch, Barbara M. Rainer, Maximilian C. Koeller, Martin Pichler, Hanno Gerritsmann, Karl Kashofer, Ariane Aigelsreiter   +16 more
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Dynamics of circulating tumor DNA during postoperative radiotherapy for triple-negative breast cancer in patients undergoing neoadjuvant chemotherapy and breast surgery

, 2021
H. Kim, Y.J. Kim, D. Park, W.-Y. Park, Dong Hee Choi, W. Park, W.K. Cho   +6 more
openalex   +1 more source