Results 111 to 120 of about 2,960,910 (293)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Plasma circulating tumor DNA as a potential tool for disease monitoring in head and neck cancer

, 2019
Recommendations for perioperative therapy in head and neck cancer are not explicit and recurrence occurs frequently. Circulating tumor DNA is an emerging cancer biomarker, but has not been extensively explored for detection of recurrence in head and neck
Anders Ståhlberg, Saunders, Stefanie, Tony E. Godfrey, Irina Kalatskaya, Krzyzanowski, Paul M, Anand Devaiah, Paul M. Krzyzanowski, Stefanie Saunders, Ståhlberg, Anders,, Devaiah, Anand, Filges, Stefan,, Jalisi, Scharukh, Stein, Lincoln D, Sridhar, Praveen, Godfrey, Tony E, Egyud, Matthew, Jiao, Wei, Lincoln D. Stein, Stefan Filges, Scharukh Jalisi, Matthew Egyud, Yamada, Emiko, Praveen Sridhar, Emiko Yamada, Wei Jiao, Kalatskaya, Irina   +25 more
core   +1 more source

Direct Involvement of Retinoblastoma Family Proteins in DNA Repair by Non-homologous End-Joining. [PDF]

, 2015
Deficiencies in DNA double-strand break (DSB) repair lead to genetic instability, a recognized cause of cancer initiation and evolution. We report that the retinoblastoma tumor suppressor protein (RB1) is required for DNA DSB repair by canonical non ...
Spanswick, VJ, Maciej T. Luczynski, Rieger, Simone, Luczynski, Maciej T., Cook, Rebecca, Cook, R, Hartley, JA, Paul H. Huang, Victoria J. Spanswick, Huang, Paul H., Hartley, John A., John A. Hartley, Luczynski, MT, Rieger, S, Mittnacht, Sibylle, Mittnacht, S, Spanswick, Victoria J., Moquet, J, Huang, PH, Kai Rothkamm, Zoumpoulidou, Georgia, Jayne Moquet, Zoumpoulidou, G, Georgia Zoumpoulidou, Simone Rieger, Sibylle Mittnacht, Rothkamm, K, Rebecca Cook, Moquet, Jayne, Rothkamm, Kai   +29 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Circulating tumor DNA. Modern views about the possibility of use in uveal melanoma

Российский офтальмологический журнал
Choroidal melanoma is the most common and highly malignant intraocular tumor due to its tendency to hematogenous metastasis. In the vast majority of cases, the liver is affected.
A. M. Bogatyrev, E. E. Grishina, A. R. Zaretsky, P. I. Semenikhina   +3 more
doaj   +1 more source

Liquid Biopsy in Gastrointestinal Cancers

Diagnostics, 2018
Liquid biopsy is the sampling of any biological fluid in an effort to enrich and analyze a tumor’s genetic material. Peripheral blood remains the most studied liquid biopsy material, with circulating tumor cells (CTC’s) and circulating tumor ...
Aman Saini, Yash Pershad, Hassan Albadawi, Malia Kuo, Sadeer Alzubaidi, Sailendra Naidu, M-Grace Knuttinen, Rahmi Oklu   +7 more
doaj   +1 more source

Circulating tumor DNA related to tumor dynamics in cervical cancer patients.

, 2012
Circulating tumor DNA related to tumor dynamics in cervical cancer patients.
Emmanuelle Lappartient (140028), Virginie Fourchotte (140038), Anne de la Rochefordière (140034), Jean-Yves Pierga (29242), Stéphanie Saada (140031), Emmanuelle Jeannot (140022), Maura Campitelli (140015), Martine Peter (140025), Peter Petrow (631), Xavier Sastre-Garau (29244), Séverine Alran (140041), Jérôme Couturier (81165), Paul Cottu (140044), Olivier Lantz (46680)   +13 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source